Bioquímica e Biologia Humana

Principais Atividades

Ensino de 1.º, 2.º e 3.º ciclos.
Investigação científica e desenvolvimento tecnológico.
Serviços de extensão universitária:
            serviços ao exterior
            atividades complementares no domínio da formação contínua e da promoção da inovação.

Órgãos

Presidente
Maria da Graça Tavares Rebelo de Soveral Rodrigues

Comissão Executiva
Ana Paula Costa Santos Peralta Leandro (Recursos Financeiros)
Isabel Maria Antolin Rivera (Serviço Docente e Qualidade Pedagógica)
Maria João Carlos Silva Gama (Recursos Humanos e Segurança)
Rui Fernando Marques da Silva (Recursos e Estruturas)

Ensino

O DBBH está ativamente envolvido na lecionação de vários cursos da FFUL e também de alguns cursos em associação com Escolas da ULisboa ou outras instituições de ensino superior.

Especialidades de Biologia Celular e Molecular, de Bioquímica, de Biotecnologia Farmacêutica e Toxicologia.

Programa Doutoral em Medicamento e Inovação Farmacêutica (i3DU)

Licenciatura
Ciências da Saúde (ciclo de estudos em associação)

Mestrado Integrado
Mestrado Integrado em Engenharia Biomédica e Biofísica da Faculdade de Ciências da ULisboa

Mestrado
Mestrado em Biologia Molecular e Genética da Faculdade de Ciências da ULisboa

Programas Doutorais
Programa Doutoral em Bioquímica e Biofísica Médica (M2B-PhD)
Programa Doutoral em Microsistemas Integrados Avançados (AIM)
Programa Doutoral em Neurociências Integradas (NeurULisboa)
Programa Doutoral em Química Medicinal (MedChemTrain)

Cursos Não Conferentes de Grau
Curso Avançado Biomarkers and Assay Development, 14-18 de setembro de 2015
XX Curso de pós-graduação e atualização em Hematologia – 2.ª edição. Patologia Leucocitária, 21 e 22 de fevereiro de 2015
XX Curso de pós-graduação e atualização em Hematologia – 3.ª edição. Patologia Leucocitária, 20 e 21 de junho de 2015
XXI Curso de pós-graduação e atualização em Hematologia – 1.ª edição. Patologia dos eritrócitos: Anemias, poliglobulias e hemocromatoses. 11 e 12 de abril de 2015
XXII Curso de pós-graduação e atualização em Hematologia – 1.ª edição. Anemias hemolíticas, 31 de outubro e 1 de novembro de 2015

Investigação

Instituto de Investigação do Medicamento (iMed.ULisboa)

            Grupos de Investigação:
            Biologia Neuro-Glial na Saúde e na Doença
            Função Celular e Alvos Terapêuticos
            Metabolismo e Genética

2019

2018

2016

  • Afonso MB, Rodrigues PM, Simao AL, Castro RE. Circulating microRNAs as Potential Biomarkers in Non-Alcoholic Fatty Liver Disease and Hepatocellular Carcinoma. Journal o Clinical Medicine. 2016 Mar;5(3).
  • Afonso MB, Rodrigues PM, Simao AL, Cortez-Pinto H, Ofengeim D, Amaral JD, et al. RIP3 Regulates Acute Cholestasis-Associated Necroptotic Signaling and Cell Death. Journal of Hepatology. 2016;64(2):S349.
  • Afonso MB, Rodrigues PM, Simão AL, Ofengeim D, Carvalho T, Amaral JD, et al. Activation of necroptosis in human and experimental cholestasis. Cell Death and Disease. 2016;7(9).
  • Almeida A, Martins AP, Mosca AF, Wijma HJ, Prista C, Soveral G, et al. Exploring the gating mechanisms of aquaporin-3: new clues for the design of inhibitors? Molecular Biosystems. 2016;12(5):1564–73.
  • Barateiro A, Afonso V, Santos G, Cerqueira JJ, Brites D, van Horssen J, et al. S100B as a Potential Biomarker and Therapeutic Target in Multiple Sclerosis. Molecular Neurobiology. 2016;53(6):3976–91.
  • Barateiro A, Brites D, Fernandes A. Oligodendrocyte development and myelination in neurodevelopment: Molecular mechanisms in health and disease. Current Pharmaceutical Design. 2016;22(6):656–79.
  • Barateiro A, Chen S, Yueh M-F, Fernandes A, Domingues HS, Relvas J, et al. Reduced myelination and increased glia reactivity resulting from severe neonatal hyperbilirubinemia. Molecular Pharmacology. 2016;89(1):84–93.
  • Barateiro A, Mahu I, Domingos AI. Leptin Resistance and the Neuro-Adipose Connection. Frontiers In Endocrinology. 2016 Mar;8.
  • Barroso M, Kao D, Blom HJ, Tavares de Almeida I, Castro R, Loscalzo J, et al. S-adenosylhomocysteine induces inflammation through NFkB: A possible role for EZH2 in endothelial cell activation. Biochimica et Biophysica Acta - Molecular Basis of Disease. 2016;1862(1):82–92.
  • Bonito CA, Leandro P, Ventura FV, Guedes RC. Insights into Medium-chain Acyl-CoA Dehydrogenase Structure by Molecular Dynamics Simulations. Chemical Biology and Drug Design. 2016;88(2):281–92.
  • Bonito CA, Nunes J, Leandro J, Louro F, Leandro P, Ventura FV, et al. Unveiling the Pathogenic Molecular Mechanisms of the Most Common Variant (p.K329E) in Medium-Chain Acyl-CoA Dehydrogenase Deficiency by in Vitro and in Silico Approaches. Biochemistry. 2016;55(51):7086–98.
  • Carvalho AN, Firuzi O, Gama MJ, van Horssen J, Saso L. Oxidative stress and antioxidants in neurological diseases: Is there still hope? Current Drug Targets. 2016;17(16).
  • Carvalho AN, Marques C, Guedes RC, Castro-Caldas M, Rodrigues E, Van Horssen J, et al. S-Glutathionylation of Keap1: A new role for glutathione S-transferase pi in neuronal protection. FEBS Letters. 2016;590(10):1455–66.
  • Cunha C, Gomes C, Vaz AR, Brites D. Exploring New Inflammatory Biomarkers and Pathways during LPS-Induced M1 Polarization. Mediators of Inflammation. 2016;2016.
  • Direito I, Madeira A, Brito MA, Soveral G. Aquaporin-5: From structure to function and dysfunction in cancer. Cellular and Molecular Life Sciences. 2016;73(8):1623–40.
  • Drechsler S, Lynch MA, Novella S, González-Navarro H, Hecimovic S, Barini E, et al. With mouse age comes wisdom: A review and suggestions of relevant mouse models for age-related conditions. Mechanisms of Ageing and Development. 2016;160:54–68.
  • Duran M, Tavares de Almeida I. Interpretation of acylcarnitines analysis results. In: Inherited Metabolic Disease in Adults: A Clinical Guide, Part C. Oxford: Oxford University Press; 2016. p. 569–72.
  • Duran M, Tavares de Almeida I. Interpretation of organic acid analysis results. In: Interpretation of organic acid analysis results. Oxford: Oxford University Press; 2016. p. 565–8.
  • Estudante M, Soveral G, Morais JG, Benet LZ. Insights into solute carriers: physiological functions and implications in disease and pharmacokinetics. MedChemComm. 2016;7(8):1462–78.
  • Figueira I, Fernandes A, Djordjevic AM, Lopez-Contreras A, Henriques CM, Selman C, et al. Interventions for age-related diseases: Shifting the paradigm. Mechanisms of Ageing and Development. 2016;160:69–92.
  • Figueira M-E, Oliveira M, Direito R, Rocha J, Alves P, Serra A-T, et al. Protective effects of a blueberry extract in acute inflammation and collagen-induced arthritis in the rat. Biomedicine and Pharmacotherapy. 2016;83:1191–202.
  • Florindo PR, Pereira DM, Borralho PM, Costa PJ, Piedade MFM, Rodrigues CMP, et al. New [(η5-C5H5)Ru(N-N)(PPh3)][PF6]compounds: Colon anticancer activity and GLUT-mediated cellular uptake of carbohydrate-appended complexes. Dalton Transactions. 2016;45(30):11926–30.
  • Gomes SE, Simões AES, Pereira DM, Castro RE, Rodrigues CMP, Borralho PM. miR-143 or miR-145 overexpression increases cetuximab-mediated antibody-dependent cellular cytotoxicity in human colon cancer cells. Oncotarget. 2016;7(8):9368–87.
  • Gronbeck KR, Rodrigues CMP, Mahmoudi J, Bershad EM, Ling G, Bachour SP, et al. Application of Tauroursodeoxycholic Acid for Treatment of Neurological and Non-neurological Diseases: Is There a Potential for Treating Traumatic Brain Injury? Neurocritical Care. 2016;25(1):153–66.
  • Houten SM, Violante S, Ventura FV, Wanders RJA. The Biochemistry and Physiology of Mitochondrial Fatty Acid β-Oxidation and Its Genetic Disorders. Annual Review of Physiology. 2016;78:23-44.
  • Janota C, Lemere CA, Brito MA. Dissecting the Contribution of Vascular Alterations and Aging to Alzheimer’s Disease. Molecular Neurobiology. 2016;53(6):3793–811.
  • Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Arozena AA, et al. Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356. Autophagy. 2016;12(2):443.
  • Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Arozena AA, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016;12(1):1–222.
  • Madeira A, Moura T, Soveral G. Aquaporin functional detection: basics concepts on water and solute permeation. In: Aquaporins in Health and Disease: New Molecular Targets for Drug Discovery. Boca Raton: CRC Press (Taylor & Francis); 2016. p. 3–17.
  • Madeira A, Moura TF, Soveral G. Detecting aquaporin function and regulation. Frontiers in Chemistry. 2016;4(FEB).
  • Magalhaes A, Matias I, Palmela I, Brito MA, Dias S. LDL-cholesterol increases the transcytosis of molecules through endothelial monolayers. PLoS ONE. 2016;11(10).
  • Marques C, Santos-Silva C, Rodrigues C, Matos J, Moura T, Baptista MC, et al. Effect of different cocktails of cryoprotectants and calcium on bovine oocyte membrane permeability and cryosurvival. Reproduction In Domestic Animals. 2016;51(2, SI):114.
  • Mendez-Gimenez L, Becerril S, Moncada R, Valenti V, Cienfuegos JA, Ramirez B, et al. Gastric plication reduces glycemia, through the improvement of the altered expression of aquaglyceroporins in adipose tissue and liver in diet-induced obese rats. European Journal of Clinical Investigation. 2016;46(1, SI):28.
  • Moedas MF, van Cruchten AG, IJlst L, Kulik W, de Almeida IT, Diogo L, et al. Transient decrease of hepatic NAD+and amino acid alterations during treatment with valproate: new insights on drug-induced effects in vivo using targeted MS-based metabolomics. Metabolomics. 2016;12(8).
  • Morgado AL, Rodrigues CMP, Solá S. MicroRNA-145 Regulates Neural Stem Cell Differentiation Through the Sox2-Lin28/let-7 Signaling Pathway. Stem Cells. 2016;34(5):1386–95.
  • Moutinho M, Nunes MJ, Correia JC, Gama MJ, Castro-Caldas M, Cedazo-Minguez A, et al. Neuronal cholesterol metabolism increases dendritic outgrowth and synaptic markers via a concerted action of GGTase-I and Trk. Scientific Reports. 2016;6.
  • Moutinho M, Nunes MJ, Rodrigues E. Cholesterol 24-hydroxylase: Brain cholesterol metabolism and beyond. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 2016;1861(12):1911–20.
  • Mégraud F, Lehours P, Vale FF. The history of Helicobacter pylori: from phylogeography to paleomicrobiology. Clinical Microbiology and Infection. 2016;22(11):922–7.
  • Nave M, Castro RE, Rodrigues CMP, Casini A, Soveral G, Gaspar MM. Nanoformulations of a potent copper-based aquaporin inhibitor with cytotoxic effect against cancer cells. Nanomedicine. 2016;11(14):1817–30.
  • Noronha H, Araujo D, Conde C, Martins AP, Soveral G, Chaumont F, et al. The Grapevine Uncharacterized Intrinsic Protein 1 (VvXIP1) Is Regulated by Drought Stress and Transports Glycerol, Hydrogen Peroxide, Heavy Metals but Not Water. PLOS One. 2016;11(8).
  • Oleastro M, Rocha R, Vale FF. Population structure of Helicobacter Pylori isolates from Portuguese speaking countries. Helicobacter. 2016;21(1, SI):126.
  • Palmela I, Correia L, Silva R, Sasaki H, Kim K, Brites D, et al. Hydrophilic bile acids protect human blood-brain barrier endothelial cells from disruption by unconjugated bilirubin: an in vitro study. In: Ontogeny and phylogeny of brain barrier mechanisms. Lausanne: Frontiers Media SA; 2016. p. 335–45.
  • Paterna A, Gomes SE, Borralho PM, Mulhovo S, Rodrigues CMP, Ferreira M-JU. (3′R)-hydroxytabernaelegantine C: A bisindole alkaloid with potent apoptosis inducing activity in colon (HCT116, SW620) and liver (HepG2) cancer cells. Journal of Ethnopharmacology. 2016;194:236–44.
  • Paterna A, Gomes SE, Borralho PM, Mulhovo S, Rodrigues CMP, Ferreira M-JU. Vobasinyl-Iboga Alkaloids from Tabernaemontana elegans: Cell Cycle Arrest and Apoptosis-Inducing Activity in HCT116 Colon Cancer Cells. Journal of Natural Products. 2016;79(10):2624–34.
  • Pereira DM, Simões AES, Gomes SE, Castro RE, Carvalho T, Rodrigues CMP, et al. MEK5/ERK5 signaling inhibition increases colon cancer cell sensitivity to 5-fluorouracil through a p53-dependent mechanism. Oncotarget. 2016;7(23):34322–40.
  • Pereira R, Mesquita P, Matos J, Baptista M, Silva E, Horta A, et al. Effect of P2Y2 receptors modulation on bovine oocyte cryosurvival. Reproduction in Domestic Animals. 2016;51(2, SI):129.
  • Pinheiro A, Silva MJ, Pavlu-Pereira H, Florindo C, Barroso M, Marques B, et al. Complex genetic findings in a female patient with pyruvate dehydrogenase complex deficiency: Null mutations in the PDHX gene associated with unusual expression of the testis-specific PDHA2 gene in her somatic cells. Gene. 2016;591(2):417–24.
  • Pogačnik L, Pirc K, Palmela I, Skrt M, Kwang KS, Brites D, et al. Potential for brain accessibility and analysis of stability of selected flavonoids in relation to neuroprotection in vitro. Brain Research. 2016;1651:17–26.
  • Prieto-Davó A, Dias T, Gomes SE, Rodrigues S, Parera-Valadez Y, Borralho PM, et al. The madeira archipelago as a significant source of marine-derived actinomycete diversity with anticancer and antimicrobial potential. Frontiers in Microbiology. 2016;7(OCT).
  • Ribeiro CJA, Amaral JD, Rodrigues CMP, Moreira R, Santos MMM. Spirooxadiazoline oxindoles with promising in vitro antitumor activities. MedChemComm. 2016;7(3):420–5.
  • Ribeiro CJA, Rodrigues CMP, Moreira R, Santos MMM. Chemical variations on the p53 reactivation theme. Pharmaceuticals. 2016;9(2).
  • Ribeiro FF, Neves-Tomé R, Assaife-Lopes N, Santos TE, Silva RFM, Brites D, et al. Axonal elongation and dendritic branching is enhanced by adenosine A2Areceptors activation in cerebral cortical neurons. Brain Structure and Function. 2016;221(5):2777–99.
  • Rodrigues C, Mósca AF, Martins AP, Nobre T, Prista C, Antunes F, et al. Rat aquaporin-5 is pH-gated induced by phosphorylation and is implicated in oxidative stress. International Journal of Molecular Sciences. 2016;17(12).
  • Rodrigues CMP, Moshage H. Targeting TGR5 in cholangiocyte proliferation: Default topic. Gut. 2016;65(3):369–70.
  • Rodrigues PM, Afonso MB, Simao AL, Caridade M, Carvalho CC, Trindade A, et al. MIR-21 Inhibition and Obeticholic Acid Ameliorate Non-Alcoholic Steatohepatitis In Dietary Animal Models. Journal of Hepatology. 2016;64(2):S681–2.
  • Rodriguez A, Moreno NR, Balaguer I, Mendez-Gimenez L, Becerril S, Catalan V, et al. Leptin replacement improves the non-alcoholic fatty liver of ob/ob mice partly through the restoration of the altered adipose and hepatic expression of aquaglyceroporins. European Journal of Clinical Investigation. 2016;46(1, SI):29.
  • Sabir F, Loureiro-Dias MC, Prista C. Comparative analysis of sequences, polymorphisms and topology of yeasts aquaporins and aquaglyceroporins. FEMS Yeast Research. 2016;16(3).
  • Sabir F, Prista C, Madeira A, Moura T, Loureiro-Dias M, Soveral G. Water transport in yeasts. In: Yeast Membrane Transport, Advances in Experimental Medicine and Biology, vol 892. Cham, Basel: Springer; 2016. p. 107–24.
  • Simões AES, Rodrigues CMP, Borralho PM. The MEK5/ERK5 signalling pathway in cancer: a promising novel therapeutic target. Drug Discovery Today. 2016;21(10):1654–63.
  • Soveral G, Nielsen S, Casini A.(Eds). Aquaporins in Health and Disease: New Molecular Targets for Drug Discovery. Boca Raton ; London ; New York : CRC Press, Taylor & Francis Group, 2016
  • Tenreiro MM, Ferreira R, Bernardino L, Brito MA. Cellular response of the blood-brain barrier to injury: Potential biomarkers and therapeutic targets for brain regeneration. Neurobiology of Disease. 2016 Jul;91:262–73.
  • Tenreiro MM, Malho R, Silveira M, Correia ML, Brito MA. A novel tool to monitor angiogenesis in bone marrow smears: detection and quantification of endothelial progenitor cells by multiple-labeling immunofluorescence analysis. Haematologica. 2016 Jun;101(1):782–3.
  • Vale F, Vítor J, Oleastro M. Probiotics as an alternative therapy for Helicobacter pylori-associated diseases. In: Helicobacter pylori Research: From Bench to Bedside. Cham, Basel: Springer; 2016. p. 543–74.
  • Vale FF, Nunes A, Oleastro M, Gomes JP, Sampaio DA, Rocha R, et al. Genomes of Helicobacter pylori prophages. Helicobacter. 2016;21(1, SI):86.
  • Vale FF, Vítor JMB, Oleastro M. Probiotics as an alternative therapy for Helicobacter pylori-associated diseases. Helicobacter pylori Research: From Bench to Bedside. 2016. 543-574 p.
  • Vaz A, Gomes C, Cunha C, Brites D. Astrocytes in Amyotrophic Lateral Sclerosis: Harmful Effects and Strategies to Afford Neuroprotection. In: New Developments in Astrocytes Research. New York: Nova Science Publishers; 2016. p. 67–111.
  • Vicente JB, Colaço HG, Sarti P, Leandro P, Giuffrè A. S-adenosyl-L-methionine modulates CO and NO· binding to the human H2S-generating enzyme cystathionine β-synthase. Journal of Biological Chemistry. 2016;291(2):572–81.
  • von Zglinicki T, Varela Nieto I, Brites D, Karagianni N, Ortolano S, Georgopoulos S, et al. Frailty in mouse ageing: A conceptual approach. Mechanisms of Ageing and Development. 2016;160:34–40.
  • Xavier JM, Rodrigues CMP, Solá S. Mitochondria: Major Regulators of Neural Development. Neuroscientist. 2016;22(4):346–58.
  • Zarrouk O, Garcia-Tejero I, Pinto C, Genebra T, Sabir F, Prista C, et al. Aquaporins isoforms in cv. Touriga Nacional grapevine under water stress and recovery-Regulation of expression in leaves and roots. Agricultural Water Management. 2016 Jan;164(1, SI):167–75.

Contactos

Localização: Edifício H - C.2.9
Tel.: +351 217 946 400
Extensão interna: 14345
E-mail: gsoveral@ff.ulisboa.pt

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