Bioquímica e Biologia Humana

Principais Atividades

Ensino de 1.º, 2.º e 3.º ciclos.
Investigação científica e desenvolvimento tecnológico.
Serviços de extensão universitária:
            serviços ao exterior
            atividades complementares no domínio da formação contínua e da promoção da inovação.

Órgãos

Presidente
Maria da Graça Tavares Rebelo de Soveral Rodrigues

Comissão Executiva
Ana Paula Costa Santos Peralta Leandro (Recursos Financeiros)
Isabel Maria Antolin Rivera (Serviço Docente e Qualidade Pedagógica)
Maria João Carlos Silva Gama (Recursos Humanos e Segurança)
Rui Fernando Marques da Silva (Recursos e Estruturas)

Ensino

O DBBH está ativamente envolvido na lecionação de vários cursos da FFUL e também de alguns cursos em associação com Escolas da ULisboa ou outras instituições de ensino superior.

Anatomia Humana
Biologia Celular
Biologia Molecular
Bioinformática
Bioquímica I
Bioquímica II
Bioquímica Clínica
Bioquímica Clínica Analítica
Engenharia Genética
Genética Humana
Genética Molecular Experimental
Hematologia
Histologia e Embriologia
Introdução à Neurobiologia
Laboratório de Biologia
Nutrição e Dietética

Especialidades de Biologia Celular e Molecular, de Bioquímica, de Biotecnologia Farmacêutica e Toxicologia.

Programa Doutoral em Medicamento e Inovação Farmacêutica (i3DU)

Licenciatura
Ciências da Saúde (ciclo de estudos em associação)

Mestrado Integrado
Mestrado Integrado em Engenharia Biomédica e Biofísica da Faculdade de Ciências da ULisboa
Mestrado em Biologia Molecular e Genética da Faculdade de Ciências da ULisboa

Programas Doutorais
Programa Doutoral em Bioquímica e Biofísica Médica (M2B-PhD)
Programa Doutoral em Microsistemas Integrados Avançados (AIM)
Programa Doutoral em Neurociências Integradas (NeurULisboa)
Programa Doutoral em Química Medicinal (MedChemTrain)

Cursos Não Conferentes de Grau
Curso Avançado Biomarkers and Assay Development, 14-18 de setembro de 2015
XX Curso de pós-graduação e atualização em Hematologia – 2.ª edição. Patologia Leucocitária, 21 e 22 de fevereiro de 2015
XX Curso de pós-graduação e atualização em Hematologia – 3.ª edição. Patologia Leucocitária, 20 e 21 de junho de 2015
XXI Curso de pós-graduação e atualização em Hematologia – 1.ª edição. Patologia dos eritrócitos: Anemias, poliglobulias e hemocromatoses. 11 e 12 de abril de 2015
XXII Curso de pós-graduação e atualização em Hematologia – 1.ª edição. Anemias hemolíticas, 31 de outubro e 1 de novembro de 2015

Investigação

Instituto de Investigação do Medicamento (iMed.ULisboa)

            Grupos de Investigação:
            Biologia Neuro-Glial na Saúde e na Doença
            Função Celular e Alvos Terapêuticos
            Metabolismo e Genética

2017

ReferênciaTipo de Documento
Nunes A, Ramalho R, Rodrigues CMP. Morte celular no sistema nervoso. In: Rego AC, Duarte CB, Oliveira CR, editors. Neurociências. Lisboa: Lidel; 2017. p. 499–512.

Livros e Capítulos de Livros

Vicente JB, Colaço HG, Malagrinò F, Santo PE, Gutierres A, Bandeiras TM, et al. A Clinically Relevant Variant of the Human Hydrogen Sulfide-Synthesizing Enzyme Cystathionine β -Synthase: Increased CO Reactivity as a Novel Molecular Mechanism of Pathogenicity? Oxidative Medicine and Cellular Longevity. 2017;2017

Artigos

Vale FF, Nunes A, Oleastro M, Gomes JP, Sampaio DA, Rocha R, et al. Genomic structure and insertion sites of Helicobacter pylori prophages from various geographical origins. Scientific Reports. 2017;7

Artigos

Thorell K, Lehours P, Vale FF. Genomics of Helicobacter pylori. Helicobacter. 2017;22

Artigos

Tenreiro MM, Correia ML, Brito MA. Endothelial progenitor cells in multiple myeloma neovascularization: a brick to the wall. Angiogenesis. 2017;20(4):443–62

Artigos

Soveral G, Casini A. Aquaporin modulators: a patent review (2010–2015). Expert Opinion on Therapeutic Patents. 2017;27(1):49–62

Artigos

Silva B, Nunes A, Vale FF, Rocha R, Gomes JP, Dias R, et al. The expression of Helicobacter pylori tfs plasticity zone cluster is regulated by pH and adherence, and its composition is associated with differential gastric IL-8 secretion. Helicobacter. 2017;22(4)

Artigos

Santos T, Ferreira R, Quartin E, Boto C, Saraiva C, Bragança J, et al. Blue light potentiates neurogenesis induced by retinoic acid-loaded responsive nanoparticles. Acta Biomaterialia. 2017;59:293–302

Artigos

Rosa AI, Fonseca I, Nunes MJ, Moreira S, Rodrigues E, Carvalho AN, et al. Novel insights into the antioxidant role of tauroursodeoxycholic acid in experimental models of Parkinson’s disease. Biochimica et Biophysica Acta - Molecular Basis of Disease. 2017;1863(9):2171–81

Artigos

Rodrigues PM, Afonso MB, Simaõ AL, Carvalho CC, Trindade A, Duarte A, et al. MiR-21 ablation and obeticholic acid ameliorate nonalcoholic steatohepatitis in mice. Cell Death and Disease. 2017;8(4)

Artigos

Rodrigues C, Tartaro Bujak I, Mihaljević B, Soveral G, Cipak Gasparovic A. Yeast aquaporin regulation by 4-hydroxynonenal is implicated in oxidative stress response. IUBMB Life. 2017;69(5):355–62

Artigos

Ribeiro CJA, Nunes RC, Amaral JD, Gonçalves LM, Rodrigues CMP, Moreira R, et al. Spirotriazoline oxindoles: A novel chemical scaffold with in vitro anticancer properties. European Journal of Medicinal Chemistry. 2017;140:494–509

Artigos

Reis-Pardal J, Rodrigues A, Rodrigues E, Fernandez-Llimos F. Comparing cytochrome P450 pharmacogenetic information available on United States drug labels and European Union Summaries of Product Characteristics. Pharmacogenomics Journal. 2017;17(6):488–93

Artigos

Raaf N, Amhis W, Saoula H, Abid A, Nakmouche M, Balamane A, et al. Prevalence, antibiotic resistance, and MLST typing of Helicobacter pylori in Algiers, Algeria. Helicobacter. 2017;22(6)

Artigos

Pinto S, Cunha C, Barbosa M, Vaz AR, Brites D. Exosomes from NSC-34 cells transfected with hSOD1-G93A are enriched in mir-124 and drive alterations in microglia phenotype. Frontiers in Neuroscience. 2017;11(MAY)

Artigos

Pinheiro R, Braga C, Santos G, Bronze MR, Perry MJ, Moreira R, et al. Targeting Gliomas: Can a New Alkylating Hybrid Compound Make a Difference? ACS Chemical Neuroscience. 2017;8(1):50–9

Artigos

Oleastro M, Rocha R, Vale FF. Population genetic structure of Helicobacter pylori strains from Portuguese-speaking countries. Helicobacter. 2017;22(4)

Artigos

Nunes RC, Ribeiro CJA, Monteiro Â, Rodrigues CMP, Amaral JD, Santos MMM. In vitro targeting of colon cancer cells using spiropyrazoline oxindoles. European Journal of Medicinal Chemistry. 2017;139:168–79

Artigos

Moutinho M, Nunes MJ, Rodrigues E. The mevalonate pathway in neurons: It’s not just about cholesterol. Experimental Cell Research. 2017;360(1):55–60

Artigos

Morris AAM, Kozich V, Santra S, Andria G, Ben-Omran TIM, Chakrapani AB, et al. Guidelines for the diagnosis and management of cystathionine beta-synthase deficiency. Journal of Inherited Metabolic Disease. 2017 Jan;40(1):49–74

Artigos

Moreira S, Fonseca I, Nunes MJ, Rosa A, Lemos L, Rodrigues E, et al. Nrf2 activation by tauroursodeoxycholic acid in experimental models of Parkinson’s disease. Experimental Neurology. 2017;295:77–87

Artigos

Moedas MF, Adam AAA, Farelo MA, IJlst L, Chamuleau RAFM, Hoekstra R, et al. Advances in methods for characterization of hepatic urea cycle enzymatic activity in HepaRG cells using UPLC-MS/MS. Analytical Biochemistry. 2017;535:47–55

Artigos

Méndez-Giménez L, Becerril S, Moncada R, Valentí V, Fernández S, Ramírez B, et al. Gastric Plication Improves Glycemia Partly by Restoring the Altered Expression of Aquaglyceroporins in Adipose Tissue and the Liver in Obese Rats. Obesity Surgery. 2017;27(7):1763–74

Artigos

Méndez-Giménez L, Becerril S, Camões SP, Da Silva IV, Rodrigues C, Moncada R, et al. Role of aquaporin-7 in ghrelin-and GLP-1-induced improvement of pancreatic β-cell function after sleeve gastrectomy in obese rats. International Journal of Obesity. 2017;41(9):1394–402

Artigos

Martins SV, Pires VMR, Madeira AP, Nascimento M, Alfaia CM, Castro MF, et al. Novel anti-adipogenic properties of the individual trans8,cis10 conjugated linoleic acid (CLA) isomer in 3T3-L1 adipocytes. European Journal of Lipid Science and Technology. 2017;119(2)

Artigos

2016

ReferênciaTipo de Documento
Cunha C, Gomes C, Vaz AR, Brites D. Exploring New Inflammatory Biomarkers and Pathways during LPS-Induced M1 Polarization. Mediators of Inflammation. 2016;2016.

Artigos

Barateiro A, Mahu I, Domingos AI. Leptin Resistance and the Neuro-Adipose Connection. Frontiers In Endocrinology. 2016 Mar;8.

Outras Publicações Indexadas

Pogačnik L, Pirc K, Palmela I, Skrt M, Kwang KS, Brites D, et al. Potential for brain accessibility and analysis of stability of selected flavonoids in relation to neuroprotection in vitro. Brain Research. 2016;1651:17–26.

Artigos

Moutinho M, Nunes MJ, Rodrigues E. Cholesterol 24-hydroxylase: Brain cholesterol metabolism and beyond. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 2016;1861(12):1911–20.

Artigos

Carvalho AN, Marques C, Guedes RC, Castro-Caldas M, Rodrigues E, Van Horssen J, et al. S-Glutathionylation of Keap1: A new role for glutathione S-transferase pi in neuronal protection. FEBS Letters. 2016;590(10):1455–66.

Artigos

Sabir F, Prista C, Madeira A, Moura T, Loureiro-Dias M, Soveral G. Water transport in yeasts. In: Yeast Membrane Transport, Advances in Experimental Medicine and Biology, vol 892. Cham, Basel: Springer; 2016. p. 107–24.

Livros e Capítulos de Livros

Prieto-Davó A, Dias T, Gomes SE, Rodrigues S, Parera-Valadez Y, Borralho PM, et al. The madeira archipelago as a significant source of marine-derived actinomycete diversity with anticancer and antimicrobial potential. Frontiers in Microbiology. 2016;7(OCT).

Artigos

Ribeiro CJA, Rodrigues CMP, Moreira R, Santos MMM. Chemical variations on the p53 reactivation theme. Pharmaceuticals. 2016;9(2).

Artigos

Carvalho AN, Firuzi O, Gama MJ, van Horssen J, Saso L. Oxidative stress and antioxidants in neurological diseases: Is there still hope? Current Drug Targets. 2016;17(16).

Artigos

Vaz A, Gomes C, Cunha C, Brites D. Astrocytes in Amyotrophic Lateral Sclerosis: Harmful Effects and Strategies to Afford Neuroprotection. In: New Developments in Astrocytes Research. New York: Nova Science Publishers; 2016. p. 67–111.

Livros e Capítulos de Livros

Ribeiro CJA, Amaral JD, Rodrigues CMP, Moreira R, Santos MMM. Spirooxadiazoline oxindoles with promising in vitro antitumor activities. MedChemComm. 2016;7(3):420–5.

Artigos

Simões AES, Rodrigues CMP, Borralho PM. The MEK5/ERK5 signalling pathway in cancer: a promising novel therapeutic target. Drug Discovery Today. 2016;21(10):1654–63.

Artigos

von Zglinicki T, Varela Nieto I, Brites D, Karagianni N, Ortolano S, Georgopoulos S, et al. Frailty in mouse ageing: A conceptual approach. Mechanisms of Ageing and Development. 2016;160:34–40.

Artigos

Pereira R, Mesquita P, Matos J, Baptista M, Silva E, Horta A, et al. Effect of P2Y2 receptors modulation on bovine oocyte cryosurvival. Reproduction in Domestic Animals. 2016;51(2, SI):129.

Outras Publicações Indexadas

Ribeiro FF, Neves-Tomé R, Assaife-Lopes N, Santos TE, Silva RFM, Brites D, et al. Axonal elongation and dendritic branching is enhanced by adenosine A2Areceptors activation in cerebral cortical neurons. Brain Structure and Function. 2016;221(5):2777–99.

Artigos

Tenreiro MM, Ferreira R, Bernardino L, Brito MA. Cellular response of the blood-brain barrier to injury: Potential biomarkers and therapeutic targets for brain regeneration. Neurobiology of Disease. 2016 Jul;91:262–73.

Artigos

Vicente JB, Colaço HG, Sarti P, Leandro P, Giuffrè A. S-adenosyl-L-methionine modulates CO and NO· binding to the human H2S-generating enzyme cystathionine β-synthase. Journal of Biological Chemistry. 2016;291(2):572–81.

Artigos

Marques C, Santos-Silva C, Rodrigues C, Matos J, Moura T, Baptista MC, et al. Effect of different cocktails of cryoprotectants and calcium on bovine oocyte membrane permeability and cryosurvival. Reproduction In Domestic Animals. 2016;51(2, SI):114.

Outras Publicações Indexadas

Rodrigues C, Mósca AF, Martins AP, Nobre T, Prista C, Antunes F, et al. Rat aquaporin-5 is pH-gated induced by phosphorylation and is implicated in oxidative stress. International Journal of Molecular Sciences. 2016;17(12).

Artigos

Xavier JM, Rodrigues CMP, Solá S. Mitochondria: Major Regulators of Neural Development. Neuroscientist. 2016;22(4):346–58.

Artigos

Paterna A, Gomes SE, Borralho PM, Mulhovo S, Rodrigues CMP, Ferreira M-JU. Vobasinyl-Iboga Alkaloids from Tabernaemontana elegans: Cell Cycle Arrest and Apoptosis-Inducing Activity in HCT116 Colon Cancer Cells. Journal of Natural Products. 2016;79(10):2624–34.

Artigos

Gomes SE, Simões AES, Pereira DM, Castro RE, Rodrigues CMP, Borralho PM. miR-143 or miR-145 overexpression increases cetuximab-mediated antibody-dependent cellular cytotoxicity in human colon cancer cells. Oncotarget. 2016;7(8):9368–87.

Artigos

Florindo PR, Pereira DM, Borralho PM, Costa PJ, Piedade MFM, Rodrigues CMP, et al. New [(η5-C5H5)Ru(N-N)(PPh3)][PF6]compounds: Colon anticancer activity and GLUT-mediated cellular uptake of carbohydrate-appended complexes. Dalton Transactions. 2016;45(30):11926–30.

Artigos

Janota C, Lemere CA, Brito MA. Dissecting the Contribution of Vascular Alterations and Aging to Alzheimer’s Disease. Molecular Neurobiology. 2016;53(6):3793–811.

Artigos

Paterna A, Gomes SE, Borralho PM, Mulhovo S, Rodrigues CMP, Ferreira M-JU. (3′R)-hydroxytabernaelegantine C: A bisindole alkaloid with potent apoptosis inducing activity in colon (HCT116, SW620) and liver (HepG2) cancer cells. Journal of Ethnopharmacology. 2016;194:236–44.

Artigos

Contactos

Localização: Edifício H - C.2.9
Tel.: +351 217 946 400
Extensão interna: 14345
E-mail: gsoveral@ff.ulisboa.pt

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