Farmácia Galénica e Tecnologia Farmacêutica

Principais Atividades

Ensino de 1.º, 2.º e 3.º ciclos.
Investigação científica e desenvolvimento tecnológico.
Serviços de extensão universitária:
            serviços ao exterior
            atividades complementares no domínio da formação contínua e da promoção da inovação.


Helena Maria Cabral Marques

Comissão Executiva
António José Almeida
Helena Maria Cabral Marques
Helena Margarida Ribeiro
João Pinto
Maria Bárbara dos Anjos Figueira Martins

Comissão de Departamento
A Comissão de Departamento é constituída pelos Doutores do DFGTF com vínculo à FFUL.


Instituto de Investigação do Medicamento (iMed.ULisboa)
Grupos de Investigação:
            BioNanoCiências – Transporte de Fármacos e Imunoterapia
            Sistemas Nanoestruturados para Superar Barreiras Biológicas




  • Andrade VM, Aschner M, Marreilha dos Santos AP. Neurotoxicity of Metal Mixtures. In: Michael AschnerLucio G. Costa, editor. Neurotoxicity of Metals. Cham: Springer; 2017. p. 227–65.
  • Anes E. Acting on Actin During Bacterial Infection. In: Jose C. Jimenez-Lopez, editor. Cytoskeleton - Structure, Dynamics, Function and Disease. London: InTech; 2017. p. 257–78.
  • Bettencourt P, Carmo N, Pires D, Timóteo P, Anes E. Mycobacterial infection of macrophages: the effect of the multiplicity of infection. In: Antimicrobial Research: Novel bioknowledge and educational programs. Badajóz: Formatex Research Center;
  • Gregorí Valdes BS, Vilela CCM, Ascenso A, Bordado JM RH. Topical formulations for onychomycosis: a review. In: Ascenso A, Ribeiro HM, Simões S, editors. Carrier-Mediated Dermal Delivery: Applications in the Prevention and Treatment of Skin Disorders. Singapore: Pan Stanford; 2017. p. 503–53.
  • Ismaili L, Romero A, Carreiras MC, Marco-Contelles J. Multitarget-Directed Antioxidants as Therapeutic Agents. In: Michael Decker, editor. Design of Hybrid Molecules for Drug Development. Amsterdam: Elsevier; 2017. p. 5–46.
  • Lambricht L, Peres C, Florindo H, Préat V, Vandermeulen G. Polymer-Based Nanoparticles as Modern Vaccine Delivery Systems. In: Skwarczynski M, Toth I, editors. Micro and Nanotechnology in Vaccine Development. Oxford: William Andrew Publishing; 2017. p. 185–203.
  • Lana J, Ascenso A. New Trends in Anti-Aging Skin Care. In: Ascenso A, Ribeiro HM, Simões S, editors. Carrier-Mediated Dermal Delivery: Applications in the Prevention and Treatment of Skin Disorders. Singapore: Pan Stanford; 2017. p. 3–41.
  • Malmir M, Serrano R, Silva O. Anthraquinones as potential antimicrobial agents-A review. In: A. Méndez-Vilas, editor. Antimicrobial research: Novel bioknowledge and educational programs. Badajoz: Formatex Research Center; 2017. p. 55-61.
  • Manteigas P, Ascenso A. Melatonin: a “guardian” of the genome and cellular integrity for prevention of photocarcinogenesis. In: Ascenso A, Ribeiro HM, Simões S, editors. Carrier-Mediated Dermal Delivery: Applications in the Prevention and Treatment of Skin Disorders. Singapore: Pan Stanford; 2017. p. 43–90.
  • Marto J, Jorge I, Almeida A, Ribeiro H. Novel starch-derived topical delivery systems. In: Ascenso A, Ribeiro H, Simões S, editors. Carrier-Mediated Dermal Delivery: Applications in the Prevention and Treatment of Skin Disorders. Singapore: Pan Stanford; 2017. p. 175–216.
  • Mendes T, Gaspar M, Simões S, Ascenso A. Lipid Vesicles for Skin Delivery: Evolution from first generation. In: Ascenso A, Ribeiro HM, Simões S, editors. Carrier-Mediated Dermal Delivery: Applications in the Prevention and Treatment of Skin Disorders. Singapore: Pan Stanford; 2017. p. 281–321.
  • Nunes A, Ramalho R, Rodrigues CMP. Morte celular no sistema nervoso. In: Rego AC, Duarte CB, Oliveira CR, editors. Neurociências. Lisboa: Lidel; 2017. p. 499–512.
  • Paulo A, Castillo C, Neidle S. Targeting Promoter Quadruplex Nucleic Acids for Cancer Therapy. In: Chackalamannil S, Rotella D, Ward S, editors. Comprehensive medicinal chemistry III. Amsterdam: Elsevier; 2017. p. 308–40.
  • Pinheiro L, Faustino C. Amino Acid-Based Surfactants for Biomedical Applications. In: Reza Najjar, editor. Application and Characterization of Surfactants. London: InTech; 2017.
  • Pires C, Cavaco A, Vigario M. How sociodemographic features impact subjects’ opinion on packages leaflets of medicines? Australasian Medical Journal. 2017;10(9):774–84
  • Pires C, Cavaco A, Vigário M. Towards the Definition of Linguistic Metrics for Evaluating Text Readability. Journal of Quantitative Linguistics. 2017;24(4):319–49
  • Pires C, Martins F, Cavaco A, Vigário M. Automatic quantification of abbreviations in medicine package leaflets and their comprehension assessment. International Journal of E-Health and Medical Communications. 2017;8(2):47–64
  • Pires C, Vigário M, Cavaco A. Evaluation of the type and structure of the imprints used on the surface of medicines. Journal of Pharmacy Practice and Research. 2017;47(1):23–6
  • Pires D, Bernard EM, Pombo JP, Carmo N, Fialho C, Gutierrez MG, et al. Mycobacterium tuberculosis modulates miR-106b-5p to control Cathepsin S expression resulting in higher pathogen survival and poor T-cell activation. Frontiers in Immunology. 2017;8(DEC)
  • Polsinelli B, Tsigkos S, Naumann-Winter F, Mariz S, Sepodes B. Evolving prevalence of haematological malignancies in orphan designation procedures in the European Union. Orphanet Journal of Rare Diseases. 2017;12(1)
  • Pontes da Costa A, Nunes DR, Tharaud M, Oble J, Poli G, Rieger J. Palladium(0) Nanoparticles Embedded in Core–shell Nanogels as Recoverable Catalysts for the Mizoroki–Heck Reaction. ChemCatChem. 2017;9(12):2167–75
  • Raaf N, Amhis W, Saoula H, Abid A, Nakmouche M, Balamane A, et al. Prevalence, antibiotic resistance, and MLST typing of Helicobacter pylori in Algiers, Algeria. Helicobacter. 2017;22(6)
  • Raposo LR, Roma-Rodrigues C, Faísca P, Alves M, Henriques J, Carvalheiro MC, et al. Immortalization and characterization of a new canine mammary tumour cell line FR37-CMT. Veterinary and Comparative Oncology. 2017;15(3):952–67
  • Ravasco JMJM, Coelho JAS, Simeonov SP, Afonso CAM. Bifunctional Cr3+modified ion exchange resins as efficient reusable catalysts for the production and isolation of 5-hydroxymethylfurfural from glucose. RSC Advances. 2017;7(13):7555–9
  • Ravasco JMJM, Monteiro CM, Trindade AF. Cyclopropenes: A new tool for the study of biological systems. Organic Chemistry Frontiers. 2017;4(6):1167–98
  • Rebelo A, Molpeceres J, Rijo P, Reis CP. Pancreatic cancer therapy review: From classic therapeutic agents to modern nanotechnologies. Current Drug Metabolism. 2017;18(4):346–59
  • Reis C, Antunes AF, Pereira P, Reis C, Rijo P. Nanosystems for skin delivery: From drugs to cosmetics. Current Drug Metabolism. 2017;18(5):412–25
  • Reis CP, Neufeld RJ, Veiga F, Ribeiro AJ, Neufeld RJ, Veiga F, et al. Preparation of Drug-Loaded Polymeric Nanoparticles. In: Lajos P Balogh, editor. Nanomedicine in Cancer. Singapore: Pan Stanford; 2017. p. 171–214.
  • Reis MA, Ahmed OB, Spengler G, Molnár J, Lage H, Ferreira M-JU. Exploring Jolkinol D Derivatives to Overcome Multidrug Resistance in Cancer. Journal of Natural Products. 2017;80(5):1411–20
  • Reis WC, Bonetti AF, Bottacin WE, Reis AS, Souza TT, Pontarolo R, et al. Impact on process results of clinical decision support systems (CDSSS) applied to medication use: Overview of systematic reviews. Pharmacy Practice. 2017;15(4)
  • Reis-Pardal J, Rodrigues A, Rodrigues E, Fernandez-Llimos F. Comparing cytochrome P450 pharmacogenetic information available on United States drug labels and European Union Summaries of Product Characteristics. Pharmacogenomics Journal. 2017;17(6):488–93
  • Ren X, Zou L, Zhang X, Branco V, Wang J, Carvalho C, et al. Redox Signaling Mediated by Thioredoxin and Glutathione Systems in the Central Nervous System. Antioxidants and Redox Signaling. 2017;27(13):989–1010
  • Resende AP, Silva B, Braz BS, Nunes T, Gonçalves L, Delgado E. Ex vivo permeation of erythropoietin through porcine conjunctiva, cornea, and sclera. Drug Delivery and Translational Research. 2017;7(5):625–31
  • Restolho J, Barroso M, Saramago B, Dias M, Afonso CAM. Contactless decontamination of hair samples: cannabinoids. Drug Testing and Analysis. 2017;9(2):282–8
  • Rezayan AH, Hariri S, Azerang P, Ghavami G, Portugal I, Sardari S. Synthesis of novel fluorene bisamide derivatives via ugi reaction and evaluation their biological activity against Mycobacterium species. Iranian Journal of Pharmaceutical Research. 2017;16(2):724–52
  • Ribeiro CJA, Nunes RC, Amaral JD, Gonçalves LM, Rodrigues CMP, Moreira R, et al. Spirotriazoline oxindoles: A novel chemical scaffold with in vitro anticancer properties. European Journal of Medicinal Chemistry. 2017;140:494–509
  • Rocha C, Duarte J, Borrego P, Calado R, Marcelino JM, Tendeiro R, et al. Potency of HIV-2-specific antibodies increase in direct association with loss of memory B cells. AIDS. 2017;31(17):2431–3
  • Rocha Â, Teixeira R, Lourenço NMT, Afonso CAM. Enzymatic Kinetic Resolution of Secondary Alcohols Using an Ionic Anhydride Generated In Situ. ChemSusChem. 2017;10(1):296–302
  • Rodrigues C, Novais Â, Sousa C, Ramos H, Coque TM, Cantón R, et al. Elucidating constraints for differentiation of major human Klebsiella pneumoniae clones using MALDI-TOF MS. European Journal of Clinical Microbiology and Infectious Diseases. 2017;36(2):379–86
  • Rodrigues C, Tartaro Bujak I, Mihaljević B, Soveral G, Cipak Gasparovic A. Yeast aquaporin regulation by 4-hydroxynonenal is implicated in oxidative stress response. IUBMB Life. 2017;69(5):355–62
  • Rodrigues CAB, Misale A, Schiel F, Maulide N. Direct synthesis of γ-pyrones by electrophilic condensation of β-ketoesters. Organic and Biomolecular Chemistry. 2017;15(3):680–3
  • Rodrigues LM, Palma L, Santos O, Almeida MA, Bujan J, Tavares L. Excessive Weight Favours Skin Physiology - Up to a Point: Another Expression of the Obesity Paradox. Skin Pharmacology and Physiology. 2017;30(2):94–101
  • Rodrigues PM, Afonso MB, Simaõ AL, Carvalho CC, Trindade A, Duarte A, et al. MiR-21 ablation and obeticholic acid ameliorate nonalcoholic steatohepatitis in mice. Cell Death and Disease. 2017;8(4)
  • Rolim I, Duarte N, Barata G, Costa J, Gardete-Correia L, Boavida J, et al. Immunoglobulin M gene association with autoantibody reactivity and type 1 diabetes. Immunogenetics. 2017;69(7):429–37
  • Romero-Severson EO, Bulla I, Hengartner N, Bartolo I, Abecasis A, Azevedo-Pereira JM, et al. Donor-Recipient Identification in Para- and Poly-phyletic Trees Under Alternative HIV-1 Transmission Hypotheses Using Approximate Bayesian Computation. Genetics. 2017 Nov;207(3):1089–101
  • Roque L, Molpeceres J, Reis C, Rijo P, Reis CP. Past, recent progresses and future perspectives of nanotechnology applied to antifungal agents. Current Drug Metabolism. 2017;18(4):280–90
  • Roque LV, Dias IS, Cruz N, Rebelo A, Roberto A, Rijo P, et al. Design of Finasteride-Loaded Nanoparticles for Potential Treatment of Alopecia. Skin Pharmacology and Physiology. 2017;30(4):197–204
  • Rosa AI, Fonseca I, Nunes MJ, Moreira S, Rodrigues E, Carvalho AN, et al. Novel insights into the antioxidant role of tauroursodeoxycholic acid in experimental models of Parkinson’s disease. Biochimica et Biophysica Acta - Molecular Basis of Disease. 2017;1863(9):2171–81
  • Rosado C, Antunes F, Barbosa R, Fernando R, Estudante M, Silva HN, et al. About the in vivo quantitation of skin anisotropy. Skin Research and Technology. 2017;23(3):429–36
  • Rotta I, Souza TT, Salgado TM, Correr CJ, Fernandez-Llimos F. Characterization of published randomized controlled trials assessing clinical pharmacy services around the world. Research In Social & Administrative Pharmacy. 2017;13(1):201–8
  • Saldanha Do Carmo C, Maia C, Poejo J, Lychko I, Gamito P, Nogueira I, et al. Microencapsulation of α-tocopherol with zein and β-cyclodextrin using spray drying for colour stability and shelf-life improvement of fruit beverages. RSC Advances. 2017;7(51):32065–75
  • Santos CAT, Páscoa RNMJ, Lopes JA. Applications of FTIR Spectroscopy in the Wine Industry. In: Moore E, editor. Fourier transform infrared spectroscopy (FTIR) : methods, analysis, and research insights. New York: Nova Science Publishers; 2017. p. 79–120.
  • Santos DM, Aschner M, Santos APM. Manganese and Neurodegeneration. In: Anthony R. White MA, Lucio G. Costa, Ashley I. Bush, editors. Biometals in Neurodegenerative Diseases. London: Academic Press; 2017. p. 117–51.
  • Santos FMF, Matos AI, Ventura AE, Gonçalves J, Veiros LF, Florindo HF, et al. Modular Assembly of Reversible Multivalent Cancer-Cell-Targeting Drug Conjugates. Angewandte Chemie - International Edition. 2017;56(32):9346–50
  • Santos T, Ferreira R, Quartin E, Boto C, Saraiva C, Bragança J, et al. Blue light potentiates neurogenesis induced by retinoic acid-loaded responsive nanoparticles. Acta Biomaterialia. 2017;59:293–302
  • Scapin E, Frizzo CP, Rodrigues LV, Zimmer GC, Vaucher RA, Sagrillo MR, et al. Synthesis, antimicrobial activity and cytotoxic investigation of novel trifluoromethylated tetrazolo[1,5-a]pyrimidines. Medicinal Chemistry Research. 2017;26(3):640–9
  • Scomparin A, Florindo HF, Tiram G, Ferguson EL, Satchi-Fainaro R. Two-step polymer- and liposome-enzyme prodrug therapies for cancer: PDEPT and PELT concepts and future perspectives. Advanced Drug Delivery Reviews. 2017;118:52–64
  • Shamsabadi A, Ren J, Chudasama V. Enabling the facile conversion of acyl hydrazides into: N -acyl carbamates via metal-free ionic-based rupture of the N-N linkage. RSC Advances. 2017;7(44):27608–11
  • Silva AF, Sarraguça MC, Fonteyne M, Vercruysse J, De Leersnyder F, Vanhoorne V, et al. Multivariate statistical process control of a continuous pharmaceutical twin-screw granulation and fluid bed drying process. International Journal of Pharmaceutics. 2017;528(1–2):242–52
  • Silva AFT, Sarraguça MC, Ribeiro PR, Santos AO, De Beer T, Lopes JA. Statistical process control of cocrystallization processes: A comparison between OPLS and PLS. International Journal of Pharmaceutics. 2017;520(1–2):29–38
  • Silva AL, Peres C, Conniot J, Matos AI, Moura L, Carreira B, et al. Nanoparticle impact on innate immune cell pattern-recognition receptors and inflammasomes activation. Seminars In Immunology. 2017;34(C):3–24
  • Silva AS, Quintelas C, Ferreira EC, Lopes JA, Sousa C. Exploiting intrinsic fluorescence spectroscopy to discriminate between Acinetobacter calcoaceticus-Acinetobacter baumannii complex species. RSC Advances. 2017;7(14):8581–8
  • Silva B, Nunes A, Vale FF, Rocha R, Gomes JP, Dias R, et al. The expression of Helicobacter pylori tfs plasticity zone cluster is regulated by pH and adherence, and its composition is associated with differential gastric IL-8 secretion. Helicobacter. 2017;22(4)
  • Silva FC, Marto JM, Salgado A, Machado P, Silva AN, Almeida AJ. Nystatin and lidocaine pastilles for the local treatment of oral mucositis. Pharmaceutical Development and Technology. 2017;22(2):266–74
  • Silva LJG, Pereira AMPT, Rodrigues H, Meisel LM, Lino CM, Pena A. SSRIs antidepressants in marine mussels from Atlantic coastal areas and human risk assessment. Science of the Total Environment. 2017;603–604:118–25
  • Silva MM, Calado R, Marto J, Bettencourt A, Almeida AJ, Gonçalves LMD. Chitosan nanoparticles as a mucoadhesive drug delivery system for ocular administration. Marine Drugs. 2017;15(12)
  • Silva O, Serrano R. Micromorphological studies for application in the quality control of herbal medicines-some data of plants used in Mozambique. In: Méndez-Vilas A, editor. Microscopy and imaging science: practical approaches to applied research and education. Badajoz: Formatex Research Center; 2017. p. 231–6.
  • Silva T, Grenho L, Barros J, Silva JC, Pinto RV, Matos A, et al. A minocycline-releasing PMMA system as a space maintainer for staged bone reconstructions-in vitro antibacterial, cytocompatibility and anti-inflammatory characterization. Biomedical Materials (Bristol). 2017;12(3)
  • Simoes MG, Alves P, Carvalheiro M, Simoes PN. Stability effect of cholesterol-poly(acrylic acid) in a stimuli-responsive polymer-liposome complex obtained from soybean lecithin for controlled drug delivery. Colloids and Surfaces B-Biointerfaces. 2017;152:103–13
  • Simoes NG, Bettencourt AF, Monge N, Ribeiro IAC. Novel antibacterial agents: An emergent need to win the battle against infections. Mini-Reviews in Medicinal Chemistry. 2017;17(14):1364–76
  • Simões S, Carvalheiro M, Gaspar M. Lipid-based nanocarriers for the treatment of infected skin lesions. In: Ascenso A, Ribeiro HM, Simões S, editors. Carrier-Mediated Dermal Delivery: Applications in the Prevention and Treatment of Skin Disorders. Singapore: Pan Stanford; 2017. p. 387–430.
  • Sintra TE, Nasirpour M, Siopa F, Rosatella AA, Gonçalves F, Coutinho JAP, et al. Ecotoxicological evaluation of magnetic ionic liquids. Ecotoxicology and Environmental Safety. 2017;143:315–21
  • Sitarek P, Rijo P, Garcia C, Skała E, Kalemba D, Białas AJ, et al. Antibacterial, Anti-Inflammatory, Antioxidant, and Antiproliferative Properties of Essential Oils from Hairy and Normal Roots of Leonurus sibiricus L. And Their Chemical Composition. Oxidative Medicine and Cellular Longevity. 2017;2017
  • Smith D, Hornstra J, Rocha M, Jansen G, Assaraf Y, Lasry I, et al. Folic Acid Impairs the Uptake of 5-Methyltetrahydrofolate in Human Umbilical Vascular Endothelial Cells. Journal of Cardiovascular Pharmacology. 2017;70(4):271–5
  • Soares J, Espadinha M, Raimundo L, Ramos H, Gomes AS, Gomes S, et al. DIMP53-1: a novel small-molecule dual inhibitor of p53-MDM2/X interactions with multifunctional p53-dependent anticancer properties. Molecular Oncology. 2017 Jun;11(6):612–27
  • Soengas RG, Da Silva G, Estévez JC. Synthesis of spironucleosides: Past and future perspectives. Molecules. 2017;22(11)
  • Sousa A, Santos F, Gaspar MM, Calado S, Pereira JD, Mendes E, et al. The selective cytotoxicity of new triazene compounds to human melanoma cells. Bioorganic and Medicinal Chemistry. 2017;25(15):3900–10
  • Soveral G, Casini A. Aquaporin modulators: a patent review (2010–2015). Expert Opinion on Therapeutic Patents. 2017;27(1):49–62
  • Steimbach LM, Tonin FS, Virtuoso S, Souza AW, Fernandez-Llimos F, Pontarolo R. Nephrotoxicity of amphotericin-B lipid-based formulations versus conventional one: A systematic review and meta-analysis. International Journal of Clinical Pharmacy. 2017;39(1):325–6
  • Stewart D, Gibson-Smith K, MacLure K, Mair A, Alonso A, Codina C, et al. A modified Delphi study to determine the level of consensus across the European Union on the structures, processes and desired outcomes of the management of polypharmacy in older people. PLoS ONE. 2017;12(11)
  • Subtil J, Rodrigues JC, Reis L, Freitas L, Filipe J, Santos A, et al. Adenoid bacterial colonization in a paediatric population. European Archives of Oto-Rhino-Laryngology. 2017;274(4):1933–8
  • Teixeira dos Santos CA, Páscoa RNMJ, Sarraguça MC, Porto PALS, Cerdeira AL, González-Sáiz JM, et al. Merging vibrational spectroscopic data for wine classification according to the geographic origin. Food Research International. 2017;102:504–10
  • Teixeira FA, Marcos PM, Ascenso JR, Brancatelli G, Hickey N, Geremia S. Selective Binding of Spherical and Linear Anions by Tetraphenyl(thio)urea-Based Dihomooxacalix[4]arene Receptors. Journal of Organic Chemistry. 2017;82(21):11383–90
  • Tenreiro MM, Correia ML, Brito MA. Endothelial progenitor cells in multiple myeloma neovascularization: a brick to the wall. Angiogenesis. 2017;20(4):443–62
  • Thorell K, Lehours P, Vale FF. Genomics of Helicobacter pylori. Helicobacter. 2017;22
  • Tonin FS, Steimbach LM, Borba HH, Sanches AC, Wiens A, Pontarolo R, et al. Efficacy and safety of amphotericin B formulations: a network meta-analysis and a multicriteria decision analysis. Journal of Pharmacy and Pharmacology. 2017;69(12):1672–83
  • Vale FF, Nunes A, Oleastro M, Gomes JP, Sampaio DA, Rocha R, et al. Genomic structure and insertion sites of Helicobacter pylori prophages from various geographical origins. Scientific Reports. 2017;7
  • Varela ARP, Ventura AE, Carreira AC, Fedorov A, Futerman AH, Prieto M, et al. Pathological levels of glucosylceramide change the biophysical properties of artificial and cell membranes†. Physical Chemistry Chemical Physics. 2017;19(1):340–6
  • Vicente AI, Coelho JAS, Simeonov SP, Lazarova HI, Popova MD, Afonso CAM. Oxidation of 5-Chloromethylfurfural (CMF) to 2,5-Diformylfuran (DFF). Molecules. 2017;22(2)
  • Vicente AI, Esteves T, Afonso CAM, Ferreira FC. Solvent compatible polymer functionalization with adenine, a DNA base, for API degenotoxification: Preparation and characterization. Separation and Purification Technology. 2017;179:438–48
  • Vicente JB, Colaço HG, Malagrinò F, Santo PE, Gutierres A, Bandeiras TM, et al. A Clinically Relevant Variant of the Human Hydrogen Sulfide-Synthesizing Enzyme Cystathionine β -Synthase: Increased CO Reactivity as a Novel Molecular Mechanism of Pathogenicity? Oxidative Medicine and Cellular Longevity. 2017;2017
  • Viegas C, Faria T, Caetano LA, Carolino E, Gomes AQ, Viegas S. Aspergillus spp. prevalence in different Portuguese occupational environments: What is the real scenario in high load settings? Journal of Occupational and Environmental Hygiene. 2017;14(10):771–85
  • Viegas C, Faria T, de Oliveira AC, Caetano LA, Carolino E, Quintal-Gomes A, et al. A new approach to assess occupational exposure to airborne fungal contamination and mycotoxins of forklift drivers in waste sorting facilities. Mycotoxin Research. 2017;33(4):285–95
  • Viegas C, Pacífico C, Faria T, de Oliveira AC, Caetano LA, Carolino E, et al. Fungal contamination in green coffee beans samples: A public health concern. Journal of Toxicology and Environmental Health - Part A: Current Issues. 2017;80(13–15):719–28
  • Viegas S, Caetano LA, Korkalainen M, Faria T, Pacífico C, Carolino E, et al. Cytotoxic and inflammatory potential of air samples from occupational settings with exposure to organic dust. Toxics. 2017;5(1)
  • Vitorino C, Almeida AJ. Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) as topical delivery systems for antioxidants. In: Ascenso A, Ribeiro HM, Simões S, editors. Carrier-Mediated Dermal Delivery: Applications in the Prevention and Treatment of Skin Disorders. Singapore: Pan Stanford; 2017. p. 217–63.
  • Vos T, Abajobir AA, Abbafati C, Abbas KM, Abate KH, Abd-Allah F, et al. Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990-2016: A systematic analysis for the Global Burden of Disease Study 2016. The Lancet. 2017;390(10100):1211–59
  • Wang H, Abajobir AA, Abate KH, Abbafati C, Abbas KM, Abd-Allah F, et al. Global, regional, and national under-5 mortality, adult mortality, age-specific mortality, and life expectancy, 1970-2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet. 2017;390(10100):1084–150
  • Xiong S, Borrego P, Ding X, Zhu Y, Martins A, Chong H, et al. A helical short-peptide fusion inhibitor with highly potent activity against human immunodeficiency virus type 1 (HIV-1), HIV-2, and simian immunodeficiency virus. Journal of Virology. 2017;91(1)
  • Zomorodian A, Ribeiro IA, Fernandes JCS, Matos AC, Santos C, Bettencourt AF, et al. Biopolymeric coatings for delivery of antibiotic and controlled degradation of bioresorbable Mg AZ31 alloys. International Journal of Polymeric Materials and Polymeric Biomaterials. 2017;66(11):533–43


  • Afonso MB, Rodrigues PM, Simao AL, Cortez-Pinto H, Ofengeim D, Amaral JD, et al. RIP3 Regulates Acute Cholestasis-Associated Necroptotic Signaling and Cell Death. Journal of Hepatology. 2016;64(2):S349.
  • Araujo F, Goncalves J, Eurico Fonseca J. Cost savings with biosimilars in Rheumatology: a systematic literature Search Of Budget Impact Analysis. Annals of the Rheumatic Diseases. 2016 Jun;75(2):879–80.
  • Araújo F, Gonçalves J, Fonseca JE. Biosimilar DMARDs: What Does the Future Hold? Drugs. 2016;76(6):629–37.
  • Araújo FC, Gonçalves J, Fonseca JE. Pharmacoeconomics of Biosimilars: What Is There to Gain from Them? Current Rheumatology Reports. 2016;18(8).
  • Assoah B, Veiros LF, Afonso CAM, Candeias NR. Biomass-Based and Oxidant-Free Preparation of Hydroquinone from Quinic Acid. European Journal of Organic Chemistry. 2016;2016(22):3856–61.
  • Bandarra NM, Lopes PA, Martins SV, Ferreira J, Alfaia CM, Rolo EA, et al. Docosahexaenoic acid at the sn-2 position of structured triacylglycerols improved n-3 polyunsaturated fatty acid assimilation in tissues of hamsters. Nutrition Research. 2016;36(5):452–63.
  • Baptista PM, Moran EC, Vyas D, Ribeiro MH, Atala A, Sparks JL, et al. Fluid flow regulation of revascularization and cellular organization in a bioengineered liver platform. Tissue Engineering - Part C: Methods. 2016;22(3):199–207.
  • Baptista R, Ferreira RJ, Dos Santos DJVA, Fernandes MX, Ferreira M-JU. Optimizing the macrocyclic diterpenic core toward the reversal of multidrug resistance in cancer. Future Medicinal Chemistry. 2016;8(6):629–45.
  • Barateiro A, Afonso V, Santos G, Cerqueira JJ, Brites D, van Horssen J, et al. S100B as a Potential Biomarker and Therapeutic Target in Multiple Sclerosis. Molecular Neurobiology. 2016;53(6):3976–91.
  • Beloqui A, Solinís MÁ, Rodríguez-Gascón A, Almeida AJ, Préat V. Nanostructured lipid carriers: Promising drug delivery systems for future clinics. Nanomedicine: Nanotechnology, Biology, and Medicine. 2016;12(1):143–61.
  • Cabral AC, Moura-Ramos M, Caramona M, Castel-Branco M, Figueiredo I V, Fernandez-Llimos F. Developing a maastricht utrecht adherence in Hypertension Questionnaire short version: MUAH16. International Journal of Clinical Pharmacy. 2016;38(5):1339–40.
  • Carrasco MP, Machado M, Gonçalves L, Sharma M, Gut J, Lukens AK, et al. Probing the Azaaurone Scaffold against the Hepatic and Erythrocytic Stages of Malaria Parasites. ChemMedChem. 2016;2194–204.
  • Coelho J, Afonso CAM. Regioselective catalytic transfer Hydrogenation of citral. In: Comprehensive Organic Chemistry Experiments for the Laboratory Classroom. London: Royal Society of Chemistry; 2016. p. 781–3.
  • Constantino L, Dias C, Valente E. Reduction of a Ketone Using Sodium Borohydride. Control of a Reaction by TLC. In: Comprehensive Organic Chemistry Experiments for the Laboratory Classroom. London: Royal Society of Chemistry; 2016. p. 776–80.
  • Corvo ML, Marinho H, Martins M. Nanomedicines as a strategy for the therapeutic use of superoxide dismutases. In: Superoxide Dismutase (SOD): Sources, Therapeutic Uses and Health Benefits. New York: NOVA Science Publishers; 2016. p. 135–70.
  • Costa J, Machado J, Cabral MF. Preparation of a thia-tetraaza macrocyclic compound through a dual-step synthesis. In: Comprehensive Organic Chemistry Experiments for the Laboratory Classroom. London: Royal Society of Chemistry; 2016. p. 798–802.
  • Crommelin DJA, Broich K, Holloway C, Meesen B, Lizrova Preiningerova J, Prugnaud J-L, et al. The regulator’s perspective: How should new therapies and follow-on products for MS be clinically evaluated in the future? Multiple Sclerosis. 2016;22:47–59.
  • De Matas M, De Beer T, Folestad S, Ketolainen J, Lindén H, Lopes JA, et al. Strategic framework for education and training in Quality by Design (QbD) and process analytical technology (PAT). European Journal of Pharmaceutical Sciences. 2016;90:2–7.
  • Dhaouadi K, Belkhir M, Raboudi F, Mecha E, Ghommeme I, Bronze MDR, et al. Pomegranate and mint syrup addition to green tea beverage stabilized its polyphenolic content and biofunctional potentials during refrigerated storage. Journal of Food Science and Technology. 2016;53(2):1164–77.
  • Direito I, Madeira A, Brito MA, Soveral G. Aquaporin-5: From structure to function and dysfunction in cancer. Cellular and Molecular Life Sciences. 2016;73(8):1623–40.
  • Doering M, Borrego P, Büch J, Martins A, Friedrich G, Camacho RJ, et al. A genotypic method for determining HIV-2 coreceptor usage enables epidemiological studies and clinical decision support. Retrovirology. 2016;13(1).
  • Doerner T, Strand V, Cornes P, Goncalves J, Gulacsi L, Kay J, et al. The changing landscape of biosimilars in rheumatology. Annals of the Rheumatic Diseases. 2016 Jun;75(6):974–82.
  • Drechsler S, Lynch MA, Novella S, González-Navarro H, Hecimovic S, Barini E, et al. With mouse age comes wisdom: A review and suggestions of relevant mouse models for age-related conditions. Mechanisms of Ageing and Development. 2016;160:54–68.
  • Dreischulte T, Fernandez-Llimos F. Current perceptions of the term Clinical Pharmacy and its relationship to Pharmaceutical Care: a survey of members of the European Society of Clinical Pharmacy. International Journal of Clinical Pharmacy. 2016;38(6):1445–56.
  • Duarte Í, Andrade R, Pinto JF, Temtem M. Green production of cocrystals using a new solvent-free approach by spray congealing. International Journal of Pharmaceutics. 2016;506(1–2):68–78.
  • Encarnação S, de Mello-Sampayo C, Graça NAG, Catarino L, da Silva IBM, Lima BS, et al. Total phenolic content, antioxidant activity and pre-clinical safety evaluation of an Anacardium occidentale stem bark Portuguese hypoglycemic traditional herbal preparation. Industrial Crops and Products. 2016;82:171–8.
  • Figueira M-E, Oliveira M, Direito R, Rocha J, Alves P, Serra A-T, et al. Protective effects of a blueberry extract in acute inflammation and collagen-induced arthritis in the rat. Biomedicine and Pharmacotherapy. 2016;83:1191–202.
  • Florindo PR, Pereira DM, Borralho PM, Costa PJ, Piedade MFM, Rodrigues CMP, et al. New [(η5-C5H5)Ru(N-N)(PPh3)][PF6]compounds: Colon anticancer activity and GLUT-mediated cellular uptake of carbohydrate-appended complexes. Dalton Transactions. 2016;45(30):11926–30.
  • Frade R, Simão D, Afonso CAM. Isolation of Cinnamaldehyde from Cinnamon. In: Comprehensive Organic Chemistry Experiments for the Laboratory Classroom. London: Royal Society of Chemistry; 2016. p. 23–5.
  • Giria M, Santos L, Louro J, de Andrade HR. Reverse genetics vaccine seeds for influenza: Proof of concept in the source of PB1 as a determinant factor in virus growth and antigen yield. Virology. 2016;496:21–7.
  • Godinho-Santos A, Hance AJ, Goncalves J, Mammano F. CIB1 and CIB2 are HIV-1 helper factors involved in viral entry. Scientific Reports. 2016;6.
  • Gomes RFA, Afonso CAM. Alcohol Oxidation: Menthone preparation by Menthol Oxidation using pyridinium Chlorochromate immobilized in silica gel. In: Comprehensive Organic Chemistry Experiments for the Laboratory Classroom. London: Royal Society of Chemistry; 2016. p. 716–9.
  • Gomes SE, Simões AES, Pereira DM, Castro RE, Rodrigues CMP, Borralho PM. miR-143 or miR-145 overexpression increases cetuximab-mediated antibody-dependent cellular cytotoxicity in human colon cancer cells. Oncotarget. 2016;7(8):9368–87.
  • Gonçalves LMD, Maestrelli F, Mannelli LC, Ghelardini C, Almeida AJ, Mura P. Development of solid lipid nanoparticles as carriers for improving oral bioavailability of glibenclamide. European Journal of Pharmaceutics and Biopharmaceutics. 2016;102:41–50.
  • Guerreiro PS, Estácio SG, Antunes F, Fernandes AS, Pinheiro PF, Costa JG, et al. Structure-based virtual screening toward the discovery of novel inhibitors of the DNA repair activity of the human apurinic/apyrimidinic endonuclease 1. Chemical Biology and Drug Design. 2016;88(6):915–25.
  • Janota C, Lemere CA, Brito MA. Dissecting the Contribution of Vascular Alterations and Aging to Alzheimer’s Disease. Molecular Neurobiology. 2016;53(6):3793–811.
  • Lambricht L, Peres C, Florindo H, Préat V, Vandermeulen G. Polymer-based nanoparticles as modern vaccine delivery systems. In: Micro- and Nanotechnology in Vaccine Development. Amsterdam: Elsevier; 2016. p. 185–203.
  • Lavrado JP, Figueiras M, Pereira D, Santos S, Moreira R, Paulo A. Synthesis of Indolo[3,2-b]quinolin-11-one by Acid-Catalysed Intramolecular Double Cyclization. In: Comprehensive Organic Chemistry Experiments for the Laboratory Classroom. London: Royal Society of Chemistry; 2016. p. 517–21.
  • Lavrado JP, Figueiras M, Ruivo EFP, Lucas SD, Paulo A. Benzotriazole, a Useful Synthetic Auxiliary in Heterocyclizations. In: Comprehensive Organic Chemistry Experiments for the Laboratory Classroom. London: Royal Society of Chemistry; 2016. p. 539–41.
  • Magalhães LM, Machado S, Segundo MA, Lopes JA, Páscoa RNMJ. Rapid assessment of bioactive phenolics and methylxanthines in spent coffee grounds by FT-NIR spectroscopy. Talanta. 2016;147:460–7.
  • Marco-Contelles J, Unzeta M, Bolea I, Esteban G, Ramsay RR, Romero A, et al. ASS234, as a new multi-target directed propargylamine for Alzheimer’s disease therapy. Frontiers in Neuroscience. 2016;10(JUN).
  • Marcos PM, Fonseca JD, Proenca CS, Ascenso JR, Bernardino RJ, Kulesza J, et al. Experimental and computational studies of the binding properties of lower rim tetra- and di-substituted calix{[}4]arene amide derivatives with metal ions. Supramolecular Chemistry. 2016 Jun;28(5–6, SI):367–76.
  • Marinho AT, Dias CG, Pinheiro PF, Lemos AR, Antunes AMM, Marques MM, et al. Nevirapine modulation of paraoxonase-1 in the liver: An in vitro three-model approach. European Journal of Pharmaceutical Sciences. 2016;82:147–53.
  • Mariz S, Reese JH, Westermark K, Greene L, Goto T, Hoshino T, et al. Worldwide collaboration for orphan drug designation. Nature Reviews Drug Discovery. 2016;15(6):440.
  • Marques CF, Lemos A, Vieira SI, Da Cruz E Silva OAB, Bettencourt A, Ferreira JMF. Antibiotic-loaded Sr-doped porous calcium phosphate granules as multifunctional bone grafts. Ceramics International. 2016;42(2):2706–16.
  • Marçal R, Carrola J, Jarak I, Luisa Corvo M, Duarte IF, De Lourdes Pereira M. Microscopic studies of liver and kidney in mice exposed to silver nanoparticles. Microscopy and Microanalysis. 2016;22:18–9.
  • Matias AA, Rosado-Ramos R, Nunes SL, Figueira I, Serra AT, Bronze MR, et al. Protective Effect of a (Poly)phenol-Rich Extract Derived from Sweet Cherries Culls against Oxidative Cell Damage. Molecules. 2016;21(4).
  • Meirinhos A, Siopa F, Afonso CAM. Hydroxyl Group Protection via Tetrahydropyranyl Ether formation. In: Comprehensive Organic Chemistry Experiments for the Laboratory Classroom. London: Royal Society of Chemistry; 2016. p. 241–3.
  • Mendes AE, Tonin FS, Fernandez-Llimos F. Analysis of ten years of publishing in pharmacy practice. Pharmacy Practice. 2016;14(4).
  • Mendez-Gimenez L, Becerril S, Moncada R, Valenti V, Cienfuegos JA, Ramirez B, et al. Gastric plication reduces glycemia, through the improvement of the altered expression of aquaglyceroporins in adipose tissue and liver in diet-induced obese rats. European Journal of Clinical Investigation. 2016;46(1, SI):28.
  • Menezes AC, Campos PM, Euletério C, Simões S, Praça FSG, Bentley MVLB, et al. Development and characterization of novel 1-(1-Naphthyl)piperazine-loaded lipid vesicles for prevention of UV-induced skin inflammation. European Journal of Pharmaceutics and Biopharmaceutics. 2016;104:101–9.
  • Menezes AC, Raposo S, Simões S, Ribeiro H, Oliveira H, Ascenso A. Prevention of Photocarcinogenesis by Agonists of 5-HT1A and Antagonists of 5-HT2A Receptors. Molecular Neurobiology. 2016;53(2):1145–64.
  • Moedas MF, van Cruchten AG, IJlst L, Kulik W, de Almeida IT, Diogo L, et al. Transient decrease of hepatic NAD+and amino acid alterations during treatment with valproate: new insights on drug-induced effects in vivo using targeted MS-based metabolomics. Metabolomics. 2016;12(8).
  • Mograo J, Da Costa CA, Gaspar R, Florindo HF. Modulation of dendritic cells by nanotechnology-based immunotherapeutic strategies. Journal of Biomedical Nanotechnology. 2016;12(3):405–34.
  • Monteiro C, Lourenço N, Afonso CAM. Enzymatic Kinetic Resolution and separation of sec-Alcohols Methodology based on fatty esters. In: Comprehensive Organic Chemistry Experiments for the Laboratory Classroom. London: Royal Society of Chemistry; 2016. p. 923–6.
  • Morais EM, Salgado TM, Gomez IV, Duarte AM, Fernandez-Llimos F. Differences in the information about procedures after cold chain disruption provided by pharmaceutical industry to hospital and community pharmacies. European Journal of Hospital Pharmacy. 2016;23(2):96–9.
  • Moutinho M, Nunes MJ, Rodrigues E. Cholesterol 24-hydroxylase: Brain cholesterol metabolism and beyond. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 2016;1861(12):1911–20.
  • Mónico A, Paterna A, Reis M, Ferreira R, Duarte N, Madureira AM, et al. Isolation and structural identification of piperine, the major alkaloid of black pepper. In: Comprehensive Organic Chemistry Experiments for the Laboratory Classroom. London: Royal Society of Chemistry; 2016. p. 26–9.
  • Oleastro M, Rocha R, Vale FF. Population structure of Helicobacter Pylori isolates from Portuguese speaking countries. Helicobacter. 2016;21(1, SI):126.
  • Oliveira RF, Teixeira SFCF, Cabral-Marques HM, Teixeira JCF. Space chamber devices in vitro performance evaluation at constant flow. Journal of Aerosol Medicine and Pulmonary Drug Delivery. 2016 Jun;29(3):A3–4.
  • Otvagina KV, Mochalova AE, Sazanova TS, Petukhov AN, Moskvichev AA, Vorotyntsev AV, et al. Preparation and characterization of facilitated transport membranes composed of chitosan-styrene and chitosan-acrylonitrile copolymers modified by methylimidazolium based ionic liquids for CO2 separation from CH4 and N2. Membranes. 2016;6(2).
  • Paisana MC, Müllers KC, Wahl MA, Pinto JF. Production and stabilization of olanzapine nanoparticles by rapid expansion of supercritical solutions (RESS). Journal of Supercritical Fluids. 2016;109:124–33.
  • Paisana MC, Wahl MA, Pinto JF. Role of moisture on the physical stability of polymorphic olanzapine. International Journal of Pharmaceutics. 2016;509(1–2):135–48.
  • Paixão P, Gouveia L, Morais J, Silva N. Correlation between cell- and tissue-based in vitro models for drug permeability screening with in vivo situation. In: Concepts and Models for Drug Permeability Studies: Cell and Tissue based In Vitro Culture Models. Amsterdam: Elsevier; 2016. p. 357–71.
  • Palmela I, Correia L, Silva R, Sasaki H, Kim K, Brites D, et al. Hydrophilic bile acids protect human blood-brain barrier endothelial cells from disruption by unconjugated bilirubin: an in vitro study. In: Ontogeny and phylogeny of brain barrier mechanisms. Lausanne: Frontiers Media SA; 2016. p. 335–45.
  • Paterna A, Gomes SE, Borralho PM, Mulhovo S, Rodrigues CMP, Ferreira M-JU. (3′R)-hydroxytabernaelegantine C: A bisindole alkaloid with potent apoptosis inducing activity in colon (HCT116, SW620) and liver (HepG2) cancer cells. Journal of Ethnopharmacology. 2016;194:236–44.
  • Paterna A, Gomes SE, Borralho PM, Mulhovo S, Rodrigues CMP, Ferreira M-JU. Vobasinyl-Iboga Alkaloids from Tabernaemontana elegans: Cell Cycle Arrest and Apoptosis-Inducing Activity in HCT116 Colon Cancer Cells. Journal of Natural Products. 2016;79(10):2624–34.
  • Perdigão J, Maltez F, Machado D, Silva H, Pereira C, Silva C, et al. Beyond extensively drug-resistant tuberculosis in Lisbon, Portugal: a case of linezolid resistance acquisition presenting as an iliopsoas abscess. International Journal of Antimicrobial Agents. 2016;48(5):569–70.
  • Pereira AMPT, Silva LJG, Lino CM, Meisel LM, Pena A. Assessing environmental risk of pharmaceuticals in Portugal: An approach for the selection of the Portuguese monitoring stations in line with Directive 2013/39/EU. Chemosphere. 2016;144:2507–15.
  • Pereira DM, Simões AES, Gomes SE, Castro RE, Carvalho T, Rodrigues CMP, et al. MEK5/ERK5 signaling inhibition increases colon cancer cell sensitivity to 5-fluorouracil through a p53-dependent mechanism. Oncotarget. 2016;7(23):34322–40.
  • Pereira EL, Paulo A, Oliveira M, Mendes F, Raposinho P, Belchior A, et al. Radioiodinated compounds for Auger therapy. European Journal of Nuclear Medicine and Molecular Imaging. 2016;43(1):S433.
  • Pereira F, Madureira AM, Sancha S, Mulhovo S, Luo X, Duarte A, et al. Cleistochlamys kirkii chemical constituents: Antibacterial activity and synergistic effects against resistant Staphylococcus aureus strains. Journal of Ethnopharmacology. 2016;178:180–7.
  • Pereira NAL, Sureda FX, Pérez M, Amat M, Santos MMM. Enantiopure indolo[2,3-a]quinolizidines: Synthesis and evaluation as NMDA receptor antagonists. Molecules. 2016;21(8).
  • Pereira R, Mesquita P, Matos J, Baptista M, Silva E, Horta A, et al. Effect of P2Y2 receptors modulation on bovine oocyte cryosurvival. Reproduction in Domestic Animals. 2016;51(2, SI):129.
  • Piedade D, Azevedo-Pereira JM. MicroRNAs, HIV and HCV: a complex relation towards pathology. Reviews In Medical Virology. 2016;26(3):197–215.
  • Pinho S, Ramalhinho I, Filipe Mota H. Antibiotic consumption in Portugal: 2010 and 2011. International Journal of Clinical Pharmacy. 2016;38(2):564.
  • Proença S, Cipriano M, Cabral MF, Costa J, Fernandes AS, Castro M, et al. Effect of MMP inhibitors on the migration of breast cancer cells. Toxicology Letters. 2016;258(S):S141–2.
  • Páscoa RNMJ, Lopo M, Teixeira dos Santos CA, Graça AR, Lopes JA. Exploratory study on vineyards soil mapping by visible/near-infrared spectroscopy of grapevine leaves. Computers and Electronics in Agriculture. 2016;127:15–25.
  • Reis MA, Ahmed OB, Spengler G, Molnár J, Lage H, Ferreira M-JU. Jatrophane diterpenes and cancer multidrug resistance - ABCB1 efflux modulation and selective cell death induction. Phytomedicine. 2016;23(9):968–78.
  • Ribeiro CJA, Amaral JD, Rodrigues CMP, Moreira R, Santos MMM. Spirooxadiazoline oxindoles with promising in vitro antitumor activities. MedChemComm. 2016;7(3):420–5.
  • Ribeiro CJA, Espadinha M, Machado M, Gut J, Gonçalves LM, Rosenthal PJ, et al. Novel squaramides with in vitro liver stage antiplasmodial activity. Bioorganic and Medicinal Chemistry. 2016;24(8):1786–92.
  • Ribeiro FF, Neves-Tomé R, Assaife-Lopes N, Santos TE, Silva RFM, Brites D, et al. Axonal elongation and dendritic branching is enhanced by adenosine A2Areceptors activation in cerebral cortical neurons. Brain Structure and Function. 2016;221(5):2777–99.
  • Rodrigues CMP, Moshage H. Targeting TGR5 in cholangiocyte proliferation: Default topic. Gut. 2016;65(3):369–70.
  • Santos JR, Lopo M, Rangel AOSS, Lopes JA. Exploiting near infrared spectroscopy as an analytical tool for on-line monitoring of acidity during coffee roasting. Food Control. 2016;60:408–15.
  • Santos JR, Viegas O, Páscoa RNMJ, Ferreira IMPLVO, Rangel AOSS, Lopes JA. In-line monitoring of the coffee roasting process with near infrared spectroscopy: Measurement of sucrose and colour. Food Chemistry. 2016;208:103–10.
  • Santos-Costa Q, Azevedo-Pereira JM, Lopes MM, Rocheta M. A new combination of old techniques for HIV disease progression - qRT-PCR and ONEp-PCR. Journal of Clinical Virology. 2016;82(S):S43.
  • Saoudi S, Chammem N, Sifaoui I, Bouassida-Beji M, Jiménez IA, Bazzocchi IL, et al. Influence of Tunisian aromatic plants on the prevention of oxidation in soybean oil under heating and frying conditions. Food Chemistry. 2016;212:503–11.
  • Sardari S, Portugal I, ALKafri A, Moradi D, Ghavami G. Fragment-based de novo design of antimycobacterial agents and in vitro potency evaluation. Combinatorial Chemistry and High Throughput Screening. 2016;19(3):238–45.
  • Siopa F, Candeias N, Afonso CAM. Synthesis of the antitumoral drug 2,4,6-Tris(dimethylamino)-1,3,5-triazine via sequential Nucleophilic substitution. In: Comprehensive Organic Chemistry Experiments for the Laboratory Classroom. London: Royal Society of Chemistry; 2016. p. 535–8.
  • Siopa F, Figueiredo T, Frade RFM, Neto I, Meirinhos A, Reis CP, et al. Choline-Based Ionic Liquids: Improvement of Antimicrobial Activity. ChemistrySelect. 2016;1(18):5909–16.
  • Skaba E, Rijo P, Garcia C, Sitarek P, Kalemba D, Toma M, et al. The essential oils of rhaponticum carthamoides hairy roots and roots of soil-grown plants: Chemical composition and antimicrobial, anti-inflammatory, and antioxidant activities. Oxidative Medicine and Cellular Longevity. 2016;2016.
  • Soares J, Raimundo L, Pereira NAL, Monteiro Â, Gomes S, Bessa C, et al. Reactivation of wild-type and mutant p53 by tryptophanolderived oxazoloisoindolinone SLMP53-1, a novel anticancer small-molecule. Oncotarget. 2016;7(4):4326–43.
  • Teixeira dos Santos CA, Páscoa RNMJ, Lopes JA. Applications of FTIR spectroscopy in the wine industry. Fourier Transform Infrared Spectroscopy (FTIR): Methods, Analysis and Research Insights. 2016. 79-120 p.
  • Teixeira G, Martins ES, Catarino L. Antidepressant plant species from the Portuguese-speaking African countries (PALOP). In: Herbal Medicine in Depression: Traditional Medicine to Innovative Drug Delivery. Springer; 2016.p. 433-81.
  • Vale J, Afonso CAM. Grignard-Like Reaction in Water. In: Comprehensive Organic Chemistry Experiments for the Laboratory Classroom. London: Royal Society of Chemistry; 2016. p. 316–8.
  • Valente E, Dias C, Constantino L. A SN1 Reaction: Synthesis of tert-Butyl Chloride. In: Comprehensive Organic Chemistry Experiments for the Laboratory Classroom. London: Royal Society of Chemistry; 2016. p. 56–60.
  • Valente E, Dias C, Constantino L. Acetylation of Cholesterol and Purification by Column Chromatography. In: Comprehensive Organic Chemistry Experiments for the Laboratory Classroom. London: Royal Society of Chemistry; 2016. p. 142–6.
  • von Zglinicki T, Varela Nieto I, Brites D, Karagianni N, Ortolano S, Georgopoulos S, et al. Frailty in mouse ageing: A conceptual approach. Mechanisms of Ageing and Development. 2016;160:34–40.
  • Wagemaker TAL, Maia Campos PMBG, Fernandes AS, Rijo P, Nicolai M, Roberto A, et al. Unsaponifiable matter from oil of green coffee beans: cosmetic properties and safety evaluation. Drug Development and Industrial Pharmacy. 2016;42(10):1695–9.
  • Wiśniewski J, Wesołowska O, Środa-Pomianek K, Paprocka M, Bielawska-Pohl A, Krawczenko A, et al. Euphorbia species-derived diterpenes and coumarins as multidrug resistance modulators in human colon carcinoma cells. Anticancer Research. 2016;36(5):2259–64.

Instituto de Investigação do Medicamento (iMed.ULisboa)
Grupos de Investigação:
            BioNanoCiências – Transporte de Fármacos e Imunoterapia
            Sistemas Nanoestruturados para Superar Barreiras Biológicas


Edifício H – C.2.3
Tel.: +351 217 946 400
Extensão interna: 14372
Correio eletrónico: