Farmácia Galénica e Tecnologia Farmacêutica

Principais Atividades

Ensino de 1.º, 2.º e 3.º ciclos.
Investigação científica e desenvolvimento tecnológico.
Serviços de extensão universitária:
            serviços ao exterior
            atividades complementares no domínio da formação contínua e da promoção da inovação.

Órgãos

Presidente
Helena Maria Cabral Marques

Comissão Executiva
António José Almeida
Helena Maria Cabral Marques
Helena Margarida Ribeiro
João Pinto
Maria Bárbara dos Anjos Figueira Martins

Comissão de Departamento
A Comissão de Departamento é constituída pelos Doutores do DFGTF com vínculo à FFUL.

Investigação

Instituto de Investigação do Medicamento (iMed.ULisboa)
           
Grupos de Investigação:
            BioNanoCiências – Transporte de Fármacos e Imunoterapia
            Sistemas Nanoestruturados para Superar Barreiras Biológicas

2019

2018

2016

  • Adeoye O, Figueiredo A, Cabral-Marques H. Cyclodextrins and Skin Disorders: Therapeutic and Cosmetic Applications. In: Carrier-Mediated Dermal Delivery: Applications in the Prevention and Treatment of Skin Disorders. Singapore: Pan Stanford; 2016. p. 463–502.
  • Arranja A, Gouveia LF, Gener P, Rafael DF, Pereira C, Schwartz Jr. S, et al. Self-assembly PEGylation assists SLN-paclitaxel delivery inducing cancer cell apoptosis upon internalization. International Journal of Pharmaceutics. 2016 Mar;501(1–2):180–9.
  • Ascenso A, Pedrosa T, Pinho S, Pinho F, De Oliveira JMPF, Marques HC, et al. The Effect of Lycopene Preexposure on UV-B-Irradiated Human Keratinocytes. Oxidative Medicine and Cellular Longevity. 2016;2016.
  • Beloqui A, Solinís MÁ, Rodríguez-Gascón A, Almeida AJ, Préat V. Nanostructured lipid carriers: Promising drug delivery systems for future clinics. Nanomedicine: Nanotechnology, Biology, and Medicine. 2016;12(1):143–61.
  • Bettencourt AF, Feliz M, Sousa C, Gonçalves L, Neves CB. An acrylic reline resin loaded with chlorhexidine: Insights on drug release | Veiculação de clorhexidina em resinas acrílicas de rebasamento: avaliação da libertação do fármaco. Revista Portuguesa de Estomatologia, Medicina Dentaria e Cirurgia Maxilofacial. 2016;57(3):125–31.
  • Caetano LA, Almeida AJ, Gonçalves LMD. Effect of experimental parameters on alginate/chitosan microparticles for BCG encapsulation. Marine Drugs. 2016;14(5).
  • Carrasco MP, Machado M, Gonçalves L, Sharma M, Gut J, Lukens AK, et al. Probing the Azaaurone Scaffold against the Hepatic and Erythrocytic Stages of Malaria Parasites. ChemMedChem. 2016;2194–204.
  • Corvo ML, Marinho H, Martins M. Nanomedicines as a strategy for the therapeutic use of superoxide dismutases. In: Superoxide Dismutase (SOD): Sources, Therapeutic Uses and Health Benefits. New York: NOVA Science Publishers; 2016. p. 135–70.
  • Corvo ML, Mendo AS, Figueiredo S, Gaspar R, Larguinho M, da Silva MFC, et al. Liposomes as Delivery System of a Sn(IV) Complex for Cancer Therapy. Pharmaceutical Research. 2016 Jun;33(6):1351–8.
  • Corvo ML, Mendo AS, Figueiredo S, Gaspar R, Larguinho M, Guedes da Silva MFC, et al. Liposomes as Delivery System of a Sn(IV) Complex for Cancer Therapy. Pharmaceutical Research. 2016;33(6):1351–8.
  • De Matas M, De Beer T, Folestad S, Ketolainen J, Lindén H, Lopes JA, et al. Strategic framework for education and training in Quality by Design (QbD) and process analytical technology (PAT). European Journal of Pharmaceutical Sciences. 2016;90:2–7.
  • Duarte Í, Andrade R, Pinto JF, Temtem M. Green production of cocrystals using a new solvent-free approach by spray congealing. International Journal of Pharmaceutics. 2016;506(1–2):68–78.
  • Duarte Í, Andrade R, Pinto JF, Temtem M. Thermal analysis, X-ray powder diffraction and electron microscopy data related with the production of 1:1 Caffeine:Glutaric Acid cocrystals. Data in Brief. 2016;8:247–50.
  • Duarte Í, Corvo ML, Serôdio P, Vicente J, Pinto JF, Temtem M. Production of nano-solid dispersions using a novel solvent-controlled precipitation process — Benchmarking their in vivo performance with an amorphous micro-sized solid dispersion produced by spray drying. European Journal of Pharmaceutical Sciences. 2016;93:203–14.
  • Durán-Lobato M, Martín-Banderas L, Lopes R, Gonçalves LMD, Fernández-Arévalo M, Almeida AJ. Lipid nanoparticles as an emerging platform for cannabinoid delivery: Physicochemical optimization and biocompatibility. Drug Development and Industrial Pharmacy. 2016;42(2):190–8.
  • Florindo H, Lopes J, Silva L, Corvo M, Martins M, Gaspar R. Regulatory development of Nanotechnology-based vaccines. In: Micro- and Nanotechnology in Vaccine Development. Amsterdam: Elsevier; 2016. p. 393–410.
  • Fonte P, Andrade F, Azevedo C, Pinto J, Seabra V, van de Weert M, et al. Effect of the Freezing Step in the Stability and Bioactivity of Protein-Loaded PLGA Nanoparticles Upon Lyophilization. Pharmaceutical Research. 2016;33(11):2777–93.
  • Fonte P, Lino PR, Seabra V, Almeida AJ, Reis S, Sarmento B. Annealing as a tool for the optimization of lyophilization and ensuring of the stability of protein-loaded PLGA nanoparticles. International Journal of Pharmaceutics. 2016;503(1–2):163–73.
  • Gaspar D, Peres C, Florindo H, Almeida A. Mucosal immunization using polyester-based particulate systems. In: Handbook of Polyester Drug Delivery Systems. Singapore: Pan Stanford; 2016. p. 521–61.
  • Gaspar DP, Faria V, Gonçalves LMD, Taboada P, Remuñán-López C, Almeida AJ. Rifabutin-loaded solid lipid nanoparticles for inhaled antitubercular therapy: Physicochemical and in vitro studies. International Journal of Pharmaceutics. 2016;497(1–2):199–209.
  • Gener P, De Sousa Rafael DF, Fernández Y, Ortega JS, Arango D, Abasolo I, et al. Cancer stem cells and personalized cancer nanomedicine. Nanomedicine. 2016;11(3):307–20.
  • Gonçalves LMD, Maestrelli F, Mannelli LC, Ghelardini C, Almeida AJ, Mura P. Development of solid lipid nanoparticles as carriers for improving oral bioavailability of glibenclamide. European Journal of Pharmaceutics and Biopharmaceutics. 2016;102:41–50.
  • Lambricht L, Peres C, Florindo H, Préat V, Vandermeulen G. Polymer-based nanoparticles as modern vaccine delivery systems. In: Micro- and Nanotechnology in Vaccine Development. Amsterdam: Elsevier; 2016. p. 185–203.
  • Lopes RM, Pereira J, Esteves MA, Gaspar MM, Carvalheiro M, Eleutério CV, et al. Lipid-based nanoformulations of trifluralin analogs in the management of Leishmania infantuminfections. Nanomedicine. 2016;11(2):153–70.
  • Lopo M, Páscoa RNMJ, Graça AR, Lopes JA. Classification of Vineyard Soils Using Portable and Benchtop Near-Infrared Spectrometers: A Comparative Study. Soil Science Society of America Journal. 2016;80(3):652–61.
  • Magalhães LM, Machado S, Segundo MA, Lopes JA, Páscoa RNMJ. Rapid assessment of bioactive phenolics and methylxanthines in spent coffee grounds by FT-NIR spectroscopy. Talanta. 2016;147:460–7.
  • Marques CF, Matos AC, Ribeiro IAC, Gonçalves LM, Bettencourt A, Ferreira JMF. Insights on the properties of levofloxacin-adsorbed Sr- and Mg-doped calcium phosphate powders. Journal of Materials Science: Materials in Medicine. 2016;27(7).
  • Marto J, Ascenso A, Goncalves LM, Gouveia LF, Manteigas P, Pinto P, et al. Melatonin-based pickering emulsion for skin’s photoprotection. Drug Delivery. 2016;23(5, SI):1594–607.
  • Marto J, Ascenso A, Simoes S, Almeida AJ, Ribeiro HM. Pickering emulsions: challenges and opportunities in topical delivery. Expert Opinion on Drug Delivery. 2016;13(8):1093–107.
  • Marto J, Gouveia LF, Chiari BG, Paiva A, Isaac V, Pinto P, et al. The green generation of sunscreens: Using coffee industrial sub-products. Industrial Crops and Products. 2016;80:93–100.
  • Marto J, Gouveia LF, Goncalves L, Chiari-Andreo BG, Isaac V, Pinto P, et al. Design of novel starch-based Pickering emulsions as platforms for skin photoprotection. Journal of Photochemistry and Photobiology B-Biology. 2016;162:56–64.
  • Marto J, Gouveia LF, Goncalves LM, Gaspar DP, Pinto P, Carvalho FA, et al. A Quality by design (QbD) approach on starch-based nanocapsules: A promising platform for topical drug delivery. Colloids and Surfaces B-Biointerfaces. 2016 Jul;143:177–85.
  • Marto J, Jorge I, Almeida A, Ribeiro H. Novel starch-derived topical delivery systems. In: Carrier-Mediated Dermal Delivery: Applications in the Prevention and Treatment of Skin Disorders. Singapore: Pan Stanford; 2016. p. 175–216.
  • Marto J, Vitor C, Guerreiro A, Severino C, Eleuterio C, Ascenso A, et al. Ethosomes for enhanced skin delivery of griseofulvin. Colloids and Surfaces B-Biointerfaces. 2016;146:616–23.
  • Marçal R, Carrola J, Jarak I, Luisa Corvo M, Duarte IF, De Lourdes Pereira M. Microscopic studies of liver and kidney in mice exposed to silver nanoparticles. Microscopy and Microanalysis. 2016;22:18–9.
  • Menezes AC, Campos PM, Euletério C, Simões S, Praça FSG, Bentley MVLB, et al. Development and characterization of novel 1-(1-Naphthyl)piperazine-loaded lipid vesicles for prevention of UV-induced skin inflammation. European Journal of Pharmaceutics and Biopharmaceutics. 2016;104:101–9.
  • Menezes AC, Raposo S, Simões S, Ribeiro H, Oliveira H, Ascenso A. Prevention of Photocarcinogenesis by Agonists of 5-HT1A and Antagonists of 5-HT2A Receptors. Molecular Neurobiology. 2016;53(2):1145–64.
  • Mograo J, Da Costa CA, Gaspar R, Florindo HF. Modulation of dendritic cells by nanotechnology-based immunotherapeutic strategies. Journal of Biomedical Nanotechnology. 2016;12(3):405–34.
  • Moura L, Martinho N, Barata T, Florindo H, Zloh M. Computational design of a novel poly-glutamic dendrimer-based platform as an anticancer therapeutic approach. FEBS Journal. 2016;283(1, SI):231–2.
  • Oliveira RF, Cabral Marques HM, Machado A V, Teixeira JC, Teixeira SF. VHC performance evaluation at constant flow: 30 L/Min. In: Proceedings of the ASME International Mechanical Engineering Congress And Exposition, 2015, Vol 3. New York: Amer Soc Mechanical Engineers; 2016.
  • Oliveira RF, Teixeira SFCF, Cabral-Marques HM, Teixeira JCF. Space chamber devices in vitro performance evaluation at constant flow. Journal of Aerosol Medicine and Pulmonary Drug Delivery. 2016 Jun;29(3):A3–4.
  • Paisana MC, Müllers KC, Wahl MA, Pinto JF. Production and stabilization of olanzapine nanoparticles by rapid expansion of supercritical solutions (RESS). Journal of Supercritical Fluids. 2016;109:124–33.
  • Paisana MC, Wahl MA, Pinto JF. Role of moisture on the physical stability of polymorphic olanzapine. International Journal of Pharmaceutics. 2016;509(1–2):135–48.
  • Paixão P, Gouveia L, Morais J, Silva N. Correlation between cell- and tissue-based in vitro models for drug permeability screening with in vivo situation. In: Concepts and Models for Drug Permeability Studies: Cell and Tissue based In Vitro Culture Models. Amsterdam: Elsevier; 2016. p. 357–71.
  • Peres C, Matos AI, Viana AS, Graca L, Preat V, Florindo HF. Nanoparticle-based cancer vaccine to target dendritic cells and the tumor microenvironment. FEBS Journal. 2016;283(1, SI):36–7.
  • Pinto JT, Brachkova MI, Fernandes AI, Pinto JF. Evaluation of the ability of powdered milk to produce minitablets containing paracetamol for the paediatric population. Chemical Engineering Research and Design. 2016;110:171–82.
  • Páscoa RNMJ, Lopo M, Teixeira dos Santos CA, Graça AR, Lopes JA. Exploratory study on vineyards soil mapping by visible/near-infrared spectroscopy of grapevine leaves. Computers and Electronics in Agriculture. 2016;127:15–25.
  • Ribeiro CJA, Espadinha M, Machado M, Gut J, Gonçalves LM, Rosenthal PJ, et al. Novel squaramides with in vitro liver stage antiplasmodial activity. Bioorganic and Medicinal Chemistry. 2016;24(8):1786–92.
  • Ruivo EFP, Gonçalves LM, Carvalho LAR, Guedes RC, Hofbauer S, Brito JA, et al. Clickable 4-Oxo-β-lactam-Based Selective Probing for Human Neutrophil Elastase Related Proteomes. ChemMedChem. 2016;2037–42.
  • Sainz V, Peres C, Ciman T, Rodrigues C, Viana AS, Afonso CAM, et al. Optimization of protein loaded PLGA nanoparticle manufacturing parameters following a quality-by-design approach. RSC Advances. 2016;6(106):104502–12.
  • Salústio P, Miguel M, Cabral-Marques H. Molecular (Cyclodextrin) Encapsulation of Volatiles and Essential Oils. In: Handbook of Encapsulation and Controlled Release. Boca Raton: CRC Press (Taylor & Francis); 2016. p. 867–906.
  • Santos CA, Pascoa RNMJ, Porto PALS, Cerdeira AL, Lopes JA. Application of Fourier-transform infrared spectroscopy for the determination of chloride and sulfate in wines. LWT-Food Science and Technology. 2016;67:181–6.
  • Santos FMF, Rosa JN, Candeias NR, Carvalho CP, Matos AI, Ventura AE, et al. A Three-Component Assembly Promoted by Boronic Acids Delivers a Modular Fluorophore Platform (BASHY Dyes). Chemistry - A European Journal. 2016;22(44).
  • Santos FMF, Rosa JN, Candeias NR, Carvalho CP, Matos AI, Ventura AE, et al. A Three-Component Assembly Promoted by Boronic Acids Delivers a Modular Fluorophore Platform (BASHY Dyes). Chemistry - A European Journal. 2016;22(5):1631–7.
  • Santos JR, Lopo M, Rangel AOSS, Lopes JA. Exploiting near infrared spectroscopy as an analytical tool for on-line monitoring of acidity during coffee roasting. Food Control. 2016;60:408–15.
  • Santos JR, Viegas O, Páscoa RNMJ, Ferreira IMPLVO, Rangel AOSS, Lopes JA. In-line monitoring of the coffee roasting process with near infrared spectroscopy: Measurement of sucrose and colour. Food Chemistry. 2016;208:103–10.
  • Sarraguça JMG, Lima C, Machado F, Lopes JA, Almeida A, Fernandes L, et al. A FT-NIR spectroscopy methodology to estimate firing distance based on the direct analysis of the bullet impact surface. Analyst. 2016;141(14):4410–6.
  • Sarraguça MC, Matias R, Figueiredo R, Ribeiro PRS, Martins AT, Lopes JA. Near infrared spectroscopy to monitor drug release in-situ during dissolution tests. International Journal of Pharmaceutics. 2016;513(1–2):1–7.
  • Sarraguça MC, Paisana M, Pinto J, Lopes JA. Real-time monitoring of cocrystallization processes by solvent evaporation: A near infrared study. European Journal of Pharmaceutical Sciences. 2016;90:76–84.
  • Sarraguça MC, Páscoa R, Lopo M, Sarraguça JMG, Lopes JA. Bioactive compounds in coffee as health promotors. In: Natural bioactive compounds from fruits and vegetables as health promoters (vol 2). Soest (Netherlands): Bentham eBooks; 2016. p. 180–220.
  • Silva FC, Marto J, Salgado A, Silva A, Machado P, Rodrigues V, et al. Pastilles: A new approach for the treatment of oral mucositis in paediatrics. International Journal of Pharmaceutics. 2016;511(2):1147.
  • Silva S, Tobaldini-Valerio F, Costa-De-Oliveira S, Henriques M, Azeredo J, Ferreira EC, et al. Discrimination of clinically relevant: Candida species by Fourier-transform infrared spectroscopy with attenuated total reflectance (FTIR-ATR). RSC Advances. 2016;6(94):92065–72.
  • Simões S, Carvalheiro M, Gaspar MM. Lipid-based nanocarriers for cutaneous leishmaniais and buruli ulcer management. Current Pharmaceutical Design. 2016;22(43):6577–86.
  • Teixeira dos Santos CA, Páscoa RNMJ, Lopes JA. Applications of FTIR spectroscopy in the wine industry. Fourier Transform Infrared Spectroscopy (FTIR): Methods, Analysis and Research Insights. 2016. 79-120 p.
  • Varela ARP, Couto AS, Fedorov A, Futerman AH, Prieto M, Silva LC. Glucosylceramide Reorganizes Cholesterol-Containing Domains in a Fluid Phospholipid Membrane. Biophysical Journal. 2016;110(3):612–22.
  • Ventura A, Santos T, Carreira A, Martinho N, Conniot J, Varela A, et al. Drugs, delivery systems and membrane organization in model and cell membranes. In: Membrane organization and lipid rafts in the cell and artificial membranes. New York: Nova Science Publishers; 2016. p. 53–88.
  • Zupančič E, Curato C, Eisenbach L, Jung S, Florindo H. Nanotechnology-based immunotherapeutic approach for tumour eradication. European Journal of Cancer. 2016 Jul;61(1):S214.
  • Zupančič E, Peres C, Matos AI, Lopes J, Moreira JN, Gaspar RS, et al. Translational peptide-associated nanosystems: Promising role as cancer vaccines. Current Topics in Medicinal Chemistry. 2016;16(3):291–313.

Contactos

Edifício H – C.2.3
Tel.: +351 217 946 400
Extensão interna: 14372
Correio eletrónico: hcmarques@ff.ulisboa.pt

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