Toxicological and Bromatological Sciences

Main Activities

Teaching of 1st, 2nd and 3rd cycles.
Scientific research and technological development.
University extension services:
            services to community
            outreach activities in the field of continuous education and the promotion of innovation.


Head of Department
Maria do Rosário Beja de Figueiredo Gonzaga Bronze

Executive Committee
Ana Paula Marreilha
Cristina Carvalho
Judite Costa
Lídia Pinheiro
Maria Eduardo Figueira

Department Committee
The Department Committee is constituted by DCTB Doctors linked to FFUL.


Research Institute for Medicines (iMed.ULisboa)
Research Groups:
            Chemical Biology and Toxicology
            Natural Products Chemistry
            Pharmacological and Regulatory Sciences

Institute of Experimental and Technological Biology (iBET)

Center for Botany Applied to Agriculture (Instituto Superior de Agronomia, ULisboa)




  • Andrade VM, Aschner M, Marreilha dos Santos AP. Neurotoxicity of Metal Mixtures. In: Michael AschnerLucio G. Costa, editor. Neurotoxicity of Metals. Cham: Springer; 2017. p. 227–65.
  • Anes E. Acting on Actin During Bacterial Infection. In: Jose C. Jimenez-Lopez, editor. Cytoskeleton - Structure, Dynamics, Function and Disease. London: InTech; 2017. p. 257–78.
  • Bettencourt P, Carmo N, Pires D, Timóteo P, Anes E. Mycobacterial infection of macrophages: the effect of the multiplicity of infection. In: Antimicrobial Research: Novel bioknowledge and educational programs. Badajóz: Formatex Research Center;
  • Gregorí Valdes BS, Vilela CCM, Ascenso A, Bordado JM RH. Topical formulations for onychomycosis: a review. In: Ascenso A, Ribeiro HM, Simões S, editors. Carrier-Mediated Dermal Delivery: Applications in the Prevention and Treatment of Skin Disorders. Singapore: Pan Stanford; 2017. p. 503–53.
  • Ismaili L, Romero A, Carreiras MC, Marco-Contelles J. Multitarget-Directed Antioxidants as Therapeutic Agents. In: Michael Decker, editor. Design of Hybrid Molecules for Drug Development. Amsterdam: Elsevier; 2017. p. 5–46.
  • Lambricht L, Peres C, Florindo H, Préat V, Vandermeulen G. Polymer-Based Nanoparticles as Modern Vaccine Delivery Systems. In: Skwarczynski M, Toth I, editors. Micro and Nanotechnology in Vaccine Development. Oxford: William Andrew Publishing; 2017. p. 185–203.
  • Lana J, Ascenso A. New Trends in Anti-Aging Skin Care. In: Ascenso A, Ribeiro HM, Simões S, editors. Carrier-Mediated Dermal Delivery: Applications in the Prevention and Treatment of Skin Disorders. Singapore: Pan Stanford; 2017. p. 3–41.
  • Malmir M, Serrano R, Silva O. Anthraquinones as potential antimicrobial agents-A review. In: A. Méndez-Vilas, editor. Antimicrobial research: Novel bioknowledge and educational programs. Badajoz: Formatex Research Center; 2017. p. 55-61.
  • Manteigas P, Ascenso A. Melatonin: a “guardian” of the genome and cellular integrity for prevention of photocarcinogenesis. In: Ascenso A, Ribeiro HM, Simões S, editors. Carrier-Mediated Dermal Delivery: Applications in the Prevention and Treatment of Skin Disorders. Singapore: Pan Stanford; 2017. p. 43–90.
  • Marto J, Jorge I, Almeida A, Ribeiro H. Novel starch-derived topical delivery systems. In: Ascenso A, Ribeiro H, Simões S, editors. Carrier-Mediated Dermal Delivery: Applications in the Prevention and Treatment of Skin Disorders. Singapore: Pan Stanford; 2017. p. 175–216.
  • Mendes T, Gaspar M, Simões S, Ascenso A. Lipid Vesicles for Skin Delivery: Evolution from first generation. In: Ascenso A, Ribeiro HM, Simões S, editors. Carrier-Mediated Dermal Delivery: Applications in the Prevention and Treatment of Skin Disorders. Singapore: Pan Stanford; 2017. p. 281–321.
  • Nunes A, Ramalho R, Rodrigues CMP. Morte celular no sistema nervoso. In: Rego AC, Duarte CB, Oliveira CR, editors. Neurociências. Lisboa: Lidel; 2017. p. 499–512.
  • Paulo A, Castillo C, Neidle S. Targeting Promoter Quadruplex Nucleic Acids for Cancer Therapy. In: Chackalamannil S, Rotella D, Ward S, editors. Comprehensive medicinal chemistry III. Amsterdam: Elsevier; 2017. p. 308–40.
  • Pinheiro L, Faustino C. Amino Acid-Based Surfactants for Biomedical Applications. In: Reza Najjar, editor. Application and Characterization of Surfactants. London: InTech; 2017.
  • Pires C, Cavaco A, Vigario M. How sociodemographic features impact subjects’ opinion on packages leaflets of medicines? Australasian Medical Journal. 2017;10(9):774–84
  • Pires C, Cavaco A, Vigário M. Towards the Definition of Linguistic Metrics for Evaluating Text Readability. Journal of Quantitative Linguistics. 2017;24(4):319–49
  • Pires C, Martins F, Cavaco A, Vigário M. Automatic quantification of abbreviations in medicine package leaflets and their comprehension assessment. International Journal of E-Health and Medical Communications. 2017;8(2):47–64
  • Pires C, Vigário M, Cavaco A. Evaluation of the type and structure of the imprints used on the surface of medicines. Journal of Pharmacy Practice and Research. 2017;47(1):23–6
  • Pires D, Bernard EM, Pombo JP, Carmo N, Fialho C, Gutierrez MG, et al. Mycobacterium tuberculosis modulates miR-106b-5p to control Cathepsin S expression resulting in higher pathogen survival and poor T-cell activation. Frontiers in Immunology. 2017;8(DEC)
  • Polsinelli B, Tsigkos S, Naumann-Winter F, Mariz S, Sepodes B. Evolving prevalence of haematological malignancies in orphan designation procedures in the European Union. Orphanet Journal of Rare Diseases. 2017;12(1)
  • Pontes da Costa A, Nunes DR, Tharaud M, Oble J, Poli G, Rieger J. Palladium(0) Nanoparticles Embedded in Core–shell Nanogels as Recoverable Catalysts for the Mizoroki–Heck Reaction. ChemCatChem. 2017;9(12):2167–75
  • Raaf N, Amhis W, Saoula H, Abid A, Nakmouche M, Balamane A, et al. Prevalence, antibiotic resistance, and MLST typing of Helicobacter pylori in Algiers, Algeria. Helicobacter. 2017;22(6)
  • Raposo LR, Roma-Rodrigues C, Faísca P, Alves M, Henriques J, Carvalheiro MC, et al. Immortalization and characterization of a new canine mammary tumour cell line FR37-CMT. Veterinary and Comparative Oncology. 2017;15(3):952–67
  • Ravasco JMJM, Coelho JAS, Simeonov SP, Afonso CAM. Bifunctional Cr3+modified ion exchange resins as efficient reusable catalysts for the production and isolation of 5-hydroxymethylfurfural from glucose. RSC Advances. 2017;7(13):7555–9
  • Ravasco JMJM, Monteiro CM, Trindade AF. Cyclopropenes: A new tool for the study of biological systems. Organic Chemistry Frontiers. 2017;4(6):1167–98
  • Rebelo A, Molpeceres J, Rijo P, Reis CP. Pancreatic cancer therapy review: From classic therapeutic agents to modern nanotechnologies. Current Drug Metabolism. 2017;18(4):346–59
  • Reis C, Antunes AF, Pereira P, Reis C, Rijo P. Nanosystems for skin delivery: From drugs to cosmetics. Current Drug Metabolism. 2017;18(5):412–25
  • Reis CP, Neufeld RJ, Veiga F, Ribeiro AJ, Neufeld RJ, Veiga F, et al. Preparation of Drug-Loaded Polymeric Nanoparticles. In: Lajos P Balogh, editor. Nanomedicine in Cancer. Singapore: Pan Stanford; 2017. p. 171–214.
  • Reis MA, Ahmed OB, Spengler G, Molnár J, Lage H, Ferreira M-JU. Exploring Jolkinol D Derivatives to Overcome Multidrug Resistance in Cancer. Journal of Natural Products. 2017;80(5):1411–20
  • Reis WC, Bonetti AF, Bottacin WE, Reis AS, Souza TT, Pontarolo R, et al. Impact on process results of clinical decision support systems (CDSSS) applied to medication use: Overview of systematic reviews. Pharmacy Practice. 2017;15(4)
  • Reis-Pardal J, Rodrigues A, Rodrigues E, Fernandez-Llimos F. Comparing cytochrome P450 pharmacogenetic information available on United States drug labels and European Union Summaries of Product Characteristics. Pharmacogenomics Journal. 2017;17(6):488–93
  • Ren X, Zou L, Zhang X, Branco V, Wang J, Carvalho C, et al. Redox Signaling Mediated by Thioredoxin and Glutathione Systems in the Central Nervous System. Antioxidants and Redox Signaling. 2017;27(13):989–1010
  • Resende AP, Silva B, Braz BS, Nunes T, Gonçalves L, Delgado E. Ex vivo permeation of erythropoietin through porcine conjunctiva, cornea, and sclera. Drug Delivery and Translational Research. 2017;7(5):625–31
  • Restolho J, Barroso M, Saramago B, Dias M, Afonso CAM. Contactless decontamination of hair samples: cannabinoids. Drug Testing and Analysis. 2017;9(2):282–8
  • Rezayan AH, Hariri S, Azerang P, Ghavami G, Portugal I, Sardari S. Synthesis of novel fluorene bisamide derivatives via ugi reaction and evaluation their biological activity against Mycobacterium species. Iranian Journal of Pharmaceutical Research. 2017;16(2):724–52
  • Ribeiro CJA, Nunes RC, Amaral JD, Gonçalves LM, Rodrigues CMP, Moreira R, et al. Spirotriazoline oxindoles: A novel chemical scaffold with in vitro anticancer properties. European Journal of Medicinal Chemistry. 2017;140:494–509
  • Rocha C, Duarte J, Borrego P, Calado R, Marcelino JM, Tendeiro R, et al. Potency of HIV-2-specific antibodies increase in direct association with loss of memory B cells. AIDS. 2017;31(17):2431–3
  • Rocha Â, Teixeira R, Lourenço NMT, Afonso CAM. Enzymatic Kinetic Resolution of Secondary Alcohols Using an Ionic Anhydride Generated In Situ. ChemSusChem. 2017;10(1):296–302
  • Rodrigues C, Novais Â, Sousa C, Ramos H, Coque TM, Cantón R, et al. Elucidating constraints for differentiation of major human Klebsiella pneumoniae clones using MALDI-TOF MS. European Journal of Clinical Microbiology and Infectious Diseases. 2017;36(2):379–86
  • Rodrigues C, Tartaro Bujak I, Mihaljević B, Soveral G, Cipak Gasparovic A. Yeast aquaporin regulation by 4-hydroxynonenal is implicated in oxidative stress response. IUBMB Life. 2017;69(5):355–62
  • Rodrigues CAB, Misale A, Schiel F, Maulide N. Direct synthesis of γ-pyrones by electrophilic condensation of β-ketoesters. Organic and Biomolecular Chemistry. 2017;15(3):680–3
  • Rodrigues LM, Palma L, Santos O, Almeida MA, Bujan J, Tavares L. Excessive Weight Favours Skin Physiology - Up to a Point: Another Expression of the Obesity Paradox. Skin Pharmacology and Physiology. 2017;30(2):94–101
  • Rodrigues PM, Afonso MB, Simaõ AL, Carvalho CC, Trindade A, Duarte A, et al. MiR-21 ablation and obeticholic acid ameliorate nonalcoholic steatohepatitis in mice. Cell Death and Disease. 2017;8(4)
  • Rolim I, Duarte N, Barata G, Costa J, Gardete-Correia L, Boavida J, et al. Immunoglobulin M gene association with autoantibody reactivity and type 1 diabetes. Immunogenetics. 2017;69(7):429–37
  • Romero-Severson EO, Bulla I, Hengartner N, Bartolo I, Abecasis A, Azevedo-Pereira JM, et al. Donor-Recipient Identification in Para- and Poly-phyletic Trees Under Alternative HIV-1 Transmission Hypotheses Using Approximate Bayesian Computation. Genetics. 2017 Nov;207(3):1089–101
  • Roque L, Molpeceres J, Reis C, Rijo P, Reis CP. Past, recent progresses and future perspectives of nanotechnology applied to antifungal agents. Current Drug Metabolism. 2017;18(4):280–90
  • Roque LV, Dias IS, Cruz N, Rebelo A, Roberto A, Rijo P, et al. Design of Finasteride-Loaded Nanoparticles for Potential Treatment of Alopecia. Skin Pharmacology and Physiology. 2017;30(4):197–204
  • Rosa AI, Fonseca I, Nunes MJ, Moreira S, Rodrigues E, Carvalho AN, et al. Novel insights into the antioxidant role of tauroursodeoxycholic acid in experimental models of Parkinson’s disease. Biochimica et Biophysica Acta - Molecular Basis of Disease. 2017;1863(9):2171–81
  • Rosado C, Antunes F, Barbosa R, Fernando R, Estudante M, Silva HN, et al. About the in vivo quantitation of skin anisotropy. Skin Research and Technology. 2017;23(3):429–36
  • Rotta I, Souza TT, Salgado TM, Correr CJ, Fernandez-Llimos F. Characterization of published randomized controlled trials assessing clinical pharmacy services around the world. Research In Social & Administrative Pharmacy. 2017;13(1):201–8
  • Saldanha Do Carmo C, Maia C, Poejo J, Lychko I, Gamito P, Nogueira I, et al. Microencapsulation of α-tocopherol with zein and β-cyclodextrin using spray drying for colour stability and shelf-life improvement of fruit beverages. RSC Advances. 2017;7(51):32065–75
  • Santos CAT, Páscoa RNMJ, Lopes JA. Applications of FTIR Spectroscopy in the Wine Industry. In: Moore E, editor. Fourier transform infrared spectroscopy (FTIR) : methods, analysis, and research insights. New York: Nova Science Publishers; 2017. p. 79–120.
  • Santos DM, Aschner M, Santos APM. Manganese and Neurodegeneration. In: Anthony R. White MA, Lucio G. Costa, Ashley I. Bush, editors. Biometals in Neurodegenerative Diseases. London: Academic Press; 2017. p. 117–51.
  • Santos FMF, Matos AI, Ventura AE, Gonçalves J, Veiros LF, Florindo HF, et al. Modular Assembly of Reversible Multivalent Cancer-Cell-Targeting Drug Conjugates. Angewandte Chemie - International Edition. 2017;56(32):9346–50
  • Santos T, Ferreira R, Quartin E, Boto C, Saraiva C, Bragança J, et al. Blue light potentiates neurogenesis induced by retinoic acid-loaded responsive nanoparticles. Acta Biomaterialia. 2017;59:293–302
  • Scapin E, Frizzo CP, Rodrigues LV, Zimmer GC, Vaucher RA, Sagrillo MR, et al. Synthesis, antimicrobial activity and cytotoxic investigation of novel trifluoromethylated tetrazolo[1,5-a]pyrimidines. Medicinal Chemistry Research. 2017;26(3):640–9
  • Scomparin A, Florindo HF, Tiram G, Ferguson EL, Satchi-Fainaro R. Two-step polymer- and liposome-enzyme prodrug therapies for cancer: PDEPT and PELT concepts and future perspectives. Advanced Drug Delivery Reviews. 2017;118:52–64
  • Shamsabadi A, Ren J, Chudasama V. Enabling the facile conversion of acyl hydrazides into: N -acyl carbamates via metal-free ionic-based rupture of the N-N linkage. RSC Advances. 2017;7(44):27608–11
  • Silva AF, Sarraguça MC, Fonteyne M, Vercruysse J, De Leersnyder F, Vanhoorne V, et al. Multivariate statistical process control of a continuous pharmaceutical twin-screw granulation and fluid bed drying process. International Journal of Pharmaceutics. 2017;528(1–2):242–52
  • Silva AFT, Sarraguça MC, Ribeiro PR, Santos AO, De Beer T, Lopes JA. Statistical process control of cocrystallization processes: A comparison between OPLS and PLS. International Journal of Pharmaceutics. 2017;520(1–2):29–38
  • Silva AL, Peres C, Conniot J, Matos AI, Moura L, Carreira B, et al. Nanoparticle impact on innate immune cell pattern-recognition receptors and inflammasomes activation. Seminars In Immunology. 2017;34(C):3–24
  • Silva AS, Quintelas C, Ferreira EC, Lopes JA, Sousa C. Exploiting intrinsic fluorescence spectroscopy to discriminate between Acinetobacter calcoaceticus-Acinetobacter baumannii complex species. RSC Advances. 2017;7(14):8581–8
  • Silva B, Nunes A, Vale FF, Rocha R, Gomes JP, Dias R, et al. The expression of Helicobacter pylori tfs plasticity zone cluster is regulated by pH and adherence, and its composition is associated with differential gastric IL-8 secretion. Helicobacter. 2017;22(4)
  • Silva FC, Marto JM, Salgado A, Machado P, Silva AN, Almeida AJ. Nystatin and lidocaine pastilles for the local treatment of oral mucositis. Pharmaceutical Development and Technology. 2017;22(2):266–74
  • Silva LJG, Pereira AMPT, Rodrigues H, Meisel LM, Lino CM, Pena A. SSRIs antidepressants in marine mussels from Atlantic coastal areas and human risk assessment. Science of the Total Environment. 2017;603–604:118–25
  • Silva MM, Calado R, Marto J, Bettencourt A, Almeida AJ, Gonçalves LMD. Chitosan nanoparticles as a mucoadhesive drug delivery system for ocular administration. Marine Drugs. 2017;15(12)
  • Silva O, Serrano R. Micromorphological studies for application in the quality control of herbal medicines-some data of plants used in Mozambique. In: Méndez-Vilas A, editor. Microscopy and imaging science: practical approaches to applied research and education. Badajoz: Formatex Research Center; 2017. p. 231–6.
  • Silva T, Grenho L, Barros J, Silva JC, Pinto RV, Matos A, et al. A minocycline-releasing PMMA system as a space maintainer for staged bone reconstructions-in vitro antibacterial, cytocompatibility and anti-inflammatory characterization. Biomedical Materials (Bristol). 2017;12(3)
  • Simoes MG, Alves P, Carvalheiro M, Simoes PN. Stability effect of cholesterol-poly(acrylic acid) in a stimuli-responsive polymer-liposome complex obtained from soybean lecithin for controlled drug delivery. Colloids and Surfaces B-Biointerfaces. 2017;152:103–13
  • Simoes NG, Bettencourt AF, Monge N, Ribeiro IAC. Novel antibacterial agents: An emergent need to win the battle against infections. Mini-Reviews in Medicinal Chemistry. 2017;17(14):1364–76
  • Simões S, Carvalheiro M, Gaspar M. Lipid-based nanocarriers for the treatment of infected skin lesions. In: Ascenso A, Ribeiro HM, Simões S, editors. Carrier-Mediated Dermal Delivery: Applications in the Prevention and Treatment of Skin Disorders. Singapore: Pan Stanford; 2017. p. 387–430.
  • Sintra TE, Nasirpour M, Siopa F, Rosatella AA, Gonçalves F, Coutinho JAP, et al. Ecotoxicological evaluation of magnetic ionic liquids. Ecotoxicology and Environmental Safety. 2017;143:315–21
  • Sitarek P, Rijo P, Garcia C, Skała E, Kalemba D, Białas AJ, et al. Antibacterial, Anti-Inflammatory, Antioxidant, and Antiproliferative Properties of Essential Oils from Hairy and Normal Roots of Leonurus sibiricus L. And Their Chemical Composition. Oxidative Medicine and Cellular Longevity. 2017;2017
  • Smith D, Hornstra J, Rocha M, Jansen G, Assaraf Y, Lasry I, et al. Folic Acid Impairs the Uptake of 5-Methyltetrahydrofolate in Human Umbilical Vascular Endothelial Cells. Journal of Cardiovascular Pharmacology. 2017;70(4):271–5
  • Soares J, Espadinha M, Raimundo L, Ramos H, Gomes AS, Gomes S, et al. DIMP53-1: a novel small-molecule dual inhibitor of p53-MDM2/X interactions with multifunctional p53-dependent anticancer properties. Molecular Oncology. 2017 Jun;11(6):612–27
  • Soengas RG, Da Silva G, Estévez JC. Synthesis of spironucleosides: Past and future perspectives. Molecules. 2017;22(11)
  • Sousa A, Santos F, Gaspar MM, Calado S, Pereira JD, Mendes E, et al. The selective cytotoxicity of new triazene compounds to human melanoma cells. Bioorganic and Medicinal Chemistry. 2017;25(15):3900–10
  • Soveral G, Casini A. Aquaporin modulators: a patent review (2010–2015). Expert Opinion on Therapeutic Patents. 2017;27(1):49–62
  • Steimbach LM, Tonin FS, Virtuoso S, Souza AW, Fernandez-Llimos F, Pontarolo R. Nephrotoxicity of amphotericin-B lipid-based formulations versus conventional one: A systematic review and meta-analysis. International Journal of Clinical Pharmacy. 2017;39(1):325–6
  • Stewart D, Gibson-Smith K, MacLure K, Mair A, Alonso A, Codina C, et al. A modified Delphi study to determine the level of consensus across the European Union on the structures, processes and desired outcomes of the management of polypharmacy in older people. PLoS ONE. 2017;12(11)
  • Subtil J, Rodrigues JC, Reis L, Freitas L, Filipe J, Santos A, et al. Adenoid bacterial colonization in a paediatric population. European Archives of Oto-Rhino-Laryngology. 2017;274(4):1933–8
  • Teixeira dos Santos CA, Páscoa RNMJ, Sarraguça MC, Porto PALS, Cerdeira AL, González-Sáiz JM, et al. Merging vibrational spectroscopic data for wine classification according to the geographic origin. Food Research International. 2017;102:504–10
  • Teixeira FA, Marcos PM, Ascenso JR, Brancatelli G, Hickey N, Geremia S. Selective Binding of Spherical and Linear Anions by Tetraphenyl(thio)urea-Based Dihomooxacalix[4]arene Receptors. Journal of Organic Chemistry. 2017;82(21):11383–90
  • Tenreiro MM, Correia ML, Brito MA. Endothelial progenitor cells in multiple myeloma neovascularization: a brick to the wall. Angiogenesis. 2017;20(4):443–62
  • Thorell K, Lehours P, Vale FF. Genomics of Helicobacter pylori. Helicobacter. 2017;22
  • Tonin FS, Steimbach LM, Borba HH, Sanches AC, Wiens A, Pontarolo R, et al. Efficacy and safety of amphotericin B formulations: a network meta-analysis and a multicriteria decision analysis. Journal of Pharmacy and Pharmacology. 2017;69(12):1672–83
  • Vale FF, Nunes A, Oleastro M, Gomes JP, Sampaio DA, Rocha R, et al. Genomic structure and insertion sites of Helicobacter pylori prophages from various geographical origins. Scientific Reports. 2017;7
  • Varela ARP, Ventura AE, Carreira AC, Fedorov A, Futerman AH, Prieto M, et al. Pathological levels of glucosylceramide change the biophysical properties of artificial and cell membranes†. Physical Chemistry Chemical Physics. 2017;19(1):340–6
  • Vicente AI, Coelho JAS, Simeonov SP, Lazarova HI, Popova MD, Afonso CAM. Oxidation of 5-Chloromethylfurfural (CMF) to 2,5-Diformylfuran (DFF). Molecules. 2017;22(2)
  • Vicente AI, Esteves T, Afonso CAM, Ferreira FC. Solvent compatible polymer functionalization with adenine, a DNA base, for API degenotoxification: Preparation and characterization. Separation and Purification Technology. 2017;179:438–48
  • Vicente JB, Colaço HG, Malagrinò F, Santo PE, Gutierres A, Bandeiras TM, et al. A Clinically Relevant Variant of the Human Hydrogen Sulfide-Synthesizing Enzyme Cystathionine β -Synthase: Increased CO Reactivity as a Novel Molecular Mechanism of Pathogenicity? Oxidative Medicine and Cellular Longevity. 2017;2017
  • Viegas C, Faria T, Caetano LA, Carolino E, Gomes AQ, Viegas S. Aspergillus spp. prevalence in different Portuguese occupational environments: What is the real scenario in high load settings? Journal of Occupational and Environmental Hygiene. 2017;14(10):771–85
  • Viegas C, Faria T, de Oliveira AC, Caetano LA, Carolino E, Quintal-Gomes A, et al. A new approach to assess occupational exposure to airborne fungal contamination and mycotoxins of forklift drivers in waste sorting facilities. Mycotoxin Research. 2017;33(4):285–95
  • Viegas C, Pacífico C, Faria T, de Oliveira AC, Caetano LA, Carolino E, et al. Fungal contamination in green coffee beans samples: A public health concern. Journal of Toxicology and Environmental Health - Part A: Current Issues. 2017;80(13–15):719–28
  • Viegas S, Caetano LA, Korkalainen M, Faria T, Pacífico C, Carolino E, et al. Cytotoxic and inflammatory potential of air samples from occupational settings with exposure to organic dust. Toxics. 2017;5(1)
  • Vitorino C, Almeida AJ. Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) as topical delivery systems for antioxidants. In: Ascenso A, Ribeiro HM, Simões S, editors. Carrier-Mediated Dermal Delivery: Applications in the Prevention and Treatment of Skin Disorders. Singapore: Pan Stanford; 2017. p. 217–63.
  • Vos T, Abajobir AA, Abbafati C, Abbas KM, Abate KH, Abd-Allah F, et al. Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990-2016: A systematic analysis for the Global Burden of Disease Study 2016. The Lancet. 2017;390(10100):1211–59
  • Wang H, Abajobir AA, Abate KH, Abbafati C, Abbas KM, Abd-Allah F, et al. Global, regional, and national under-5 mortality, adult mortality, age-specific mortality, and life expectancy, 1970-2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet. 2017;390(10100):1084–150
  • Xiong S, Borrego P, Ding X, Zhu Y, Martins A, Chong H, et al. A helical short-peptide fusion inhibitor with highly potent activity against human immunodeficiency virus type 1 (HIV-1), HIV-2, and simian immunodeficiency virus. Journal of Virology. 2017;91(1)
  • Zomorodian A, Ribeiro IA, Fernandes JCS, Matos AC, Santos C, Bettencourt AF, et al. Biopolymeric coatings for delivery of antibiotic and controlled degradation of bioresorbable Mg AZ31 alloys. International Journal of Polymeric Materials and Polymeric Biomaterials. 2017;66(11):533–43


  • Akkapeddi P, Azizi S-A, Freedy AM, Cal PMSD, Gois PMP, Bernardes GJL. Construction of homogeneous antibody-drug conjugates using site-selective protein chemistry. Chemical Science. 2016;7(5):2954–63.
  • António J, Farias G, Cal P, Oliveira R, Santos F, Gois P. Boron-nitrogen dative bond: a useful molecular construction tool. In: Non-covalent Interactions in the Synthesis and Design of New Compounds. New Jersey: Wiley-Blackwell; 2016. p. 23–48.
  • Azevedo-Pereira JM, Santos-Costa Q. HIV interaction with human host: HIV-2 As a model of a less virulent infection. AIDS Reviews. 2016;18(1):44–53.
  • Barateiro A, Afonso V, Santos G, Cerqueira JJ, Brites D, van Horssen J, et al. S100B as a Potential Biomarker and Therapeutic Target in Multiple Sclerosis. Molecular Neurobiology. 2016;53(6):3976–91.
  • Barateiro A, Brites D, Fernandes A. Oligodendrocyte development and myelination in neurodevelopment: Molecular mechanisms in health and disease. Current Pharmaceutical Design. 2016;22(6):656–79.
  • Barateiro A, Chen S, Yueh M-F, Fernandes A, Domingues HS, Relvas J, et al. Reduced myelination and increased glia reactivity resulting from severe neonatal hyperbilirubinemia. Molecular Pharmacology. 2016;89(1):84–93.
  • Barroso M, Kao D, Blom HJ, Tavares de Almeida I, Castro R, Loscalzo J, et al. S-adenosylhomocysteine induces inflammation through NFkB: A possible role for EZH2 in endothelial cell activation. Biochimica et Biophysica Acta - Molecular Basis of Disease. 2016;1862(1):82–92.
  • Bettencourt P, Pires D, Anes E. Immunomodulating microRNAs of mycobacterial infections. Tuberculosis. 2016 Mar;97:1–7.
  • Bártolo I, Calado R, Borrego P, Leitner T, Taveira N. Rare HIV-1 subtype J genomes and a new H/U/CRF02-AG recombinant genome suggests an ancient origin of HIV-1 in Angola. AIDS Research and Human Retroviruses. 2016;32(8):822–8.
  • Cabral AC, Moura-Ramos M, Caramona M, Castel-Branco M, Figueiredo I V, Fernandez-Llimos F. Developing a maastricht utrecht adherence in Hypertension Questionnaire short version: MUAH16. International Journal of Clinical Pharmacy. 2016;38(5):1339–40.
  • Cabral AC, Rotta I, Caramona M, Castel-Branco M, Figueiredo I V, Fernandez-Llimos F. Assessing the homogeneousness in the use the 8-Items Morisky Medication Adherence Scale (MMAS-8). International Journal of Clinical Pharmacy. 2016;38(2):493.
  • Candeias NR, Góis P, Afonso CAM. Rhodium carbine C-H Insertion in Water and Catalyst Reuse. In: Comprehensive Organic Chemistry Experiments for the Laboratory Classroom. London: Royal Society of Chemistry; 2016. p. 898–902.
  • Candeias NR, Paterna R, Cal P, Góis P. Preparation of Pheylglycine and Hydroxymorpholine derivates through a Petasis Borono-Mannich Reaction. In: Comprehensive Organic Chemistry Experiments for the Laboratory Classroom. London: Royal Society of Chemistry; 2016. p. 439–42.
  • Candeias NR, Paterna R, Gois PMP. Homologation Reaction of Ketones with Diazo Compounds. Chemical Reviews. 2016;116(5):2937–81.
  • Carrasco MP, Machado M, Gonçalves L, Sharma M, Gut J, Lukens AK, et al. Probing the Azaaurone Scaffold against the Hepatic and Erythrocytic Stages of Malaria Parasites. ChemMedChem. 2016;2194–204.
  • Carvalho AN, Firuzi O, Gama MJ, van Horssen J, Saso L. Oxidative stress and antioxidants in neurological diseases: Is there still hope? Current Drug Targets. 2016;17(16).
  • Carvalho AN, Marques C, Guedes RC, Castro-Caldas M, Rodrigues E, Van Horssen J, et al. S-Glutathionylation of Keap1: A new role for glutathione S-transferase pi in neuronal protection. FEBS Letters. 2016;590(10):1455–66.
  • Cavaco AM, Pires C, Vigario M. Linguistics metrics of package leaflets: estimating effects on users’ comprehension of medicines information. International Journal of Clinical Pharmacy. 2016;38(2):506.
  • Chen C-Y, Shingai M, Borrego P, Taveira N, Strebel K. Antagonism of BST-2/tetherin is a conserved function of primary HIV-2 Env glycoproteins. Retrovirology. 2016;13(1).
  • Chen C-Y, Shingai M, Welbourn S, Martin MA, Borrego P, Taveira N, et al. Antagonism of BST-2/tetherin is a conserved function of the Env glycoprotein of primary HIV-2 isolates. Journal of Virology. 2016;90(24):11062–74.
  • Cipriano M, Belem B, Rodrigues JS, Cruz PE, Cruz H, Oliveira NG, et al. Off-the-shelf hepatocyte-like cells (HLCs): Characterization of cryopreserved human mesenchymal stem cell-derived HLCs. Toxicology Letters. 2016;258(S):S156.
  • Coelho J, Afonso CAM. Preparation of 4,5-Functionalized Cyclopentenone via Cyclization of Stenhouse Adduct. In: Comprehensive Organic Chemistry Experiments for the Laboratory Classroom. London: Royal Society of Chemistry; 2016. p. 834–7.
  • Colaco HG, Santo PE, Matias PM, Bandeiras TM, Vicente JB. Roles of Escherichia coli ZinT in cobalt, mercury and cadmium resistance and structural insights into the metal binding mechanism. Metallomics. 2016;8(3):327–36.
  • Duarte M, Ferreira P, Soares M, Martins AP, Cavaco A. Community pharmacists’ knowledge and perceptions on risk management plans in the Southern Region of Portugal. Clinical Research and Regulatory Affairs. 2016;33(2–4):33–8.
  • Duarte Í, Andrade R, Pinto JF, Temtem M. Green production of cocrystals using a new solvent-free approach by spray congealing. International Journal of Pharmaceutics. 2016;506(1–2):68–78.
  • Duarte Í, Andrade R, Pinto JF, Temtem M. Thermal analysis, X-ray powder diffraction and electron microscopy data related with the production of 1:1 Caffeine:Glutaric Acid cocrystals. Data in Brief. 2016;8:247–50.
  • Duarte Í, Corvo ML, Serôdio P, Vicente J, Pinto JF, Temtem M. Production of nano-solid dispersions using a novel solvent-controlled precipitation process — Benchmarking their in vivo performance with an amorphous micro-sized solid dispersion produced by spray drying. European Journal of Pharmaceutical Sciences. 2016;93:203–14.
  • Fernandes S, Sao-Jose C. More than a hole: the holin lethal function may be required to fully sensitize bacteria to the lytic action of canonical endolysins. Molecular Microbiology. 2016;102(1):92–106.
  • Forte E, Borisov VB, Falabella M, Colaco HG, Tinajero-Trejo M, Poole RK, et al. The Terminal Oxidase Cytochrome bd Promotes Sulfide-resistant Bacterial Respiration and Growth. Scientific Reports. 2016 Mar;6.
  • Gaffney VJ, Cardoso VV, Benoliel MJ, Almeida CMM. Chlorination and oxidation of sulfonamides by free chlorine: Identification and behaviour of reaction products by UPLC-MS/MS. Journal of Environmental Management. 2016;166:466–77.
  • Gaffney VJ, Mota-Filipe H, Pinto RA, Thiemermann C, Loureiro M, Cardoso VV, et al. Chemical and biochemical characterization and in vivo safety evaluation of pharmaceuticals in drinking water. Environmental Toxicology and Chemistry. 2016;35(11):2674–82.
  • Gaspar DP, Faria V, Gonçalves LMD, Taboada P, Remuñán-López C, Almeida AJ. Rifabutin-loaded solid lipid nanoparticles for inhaled antitubercular therapy: Physicochemical and in vitro studies. International Journal of Pharmaceutics. 2016;497(1–2):199–209.
  • Giria M, Santos L, Louro J, de Andrade HR. Reverse genetics vaccine seeds for influenza: Proof of concept in the source of PB1 as a determinant factor in virus growth and antigen yield. Virology. 2016;496:21–7.
  • Guedes RA, Serra P, Salvador JAR, Guedes RC. Computational approaches for the discovery of human proteasome inhibitors: An overview. Molecules. 2016;21(7).
  • Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Arozena AA, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016;12(1):1–222.
  • Lopes F, Perry M, Francisco A. Preparation of Nitrostilbenes by the Wittig reaction. In: Comprehensive Organic Chemistry Experiments for the Laboratory Classroom. London: Royal Society of Chemistry; 2016. p. 623–6.
  • Lopo M, Páscoa RNMJ, Graça AR, Lopes JA. Classification of Vineyard Soils Using Portable and Benchtop Near-Infrared Spectrometers: A Comparative Study. Soil Science Society of America Journal. 2016;80(3):652–61.
  • Machado D, Pires D, Perdigão J, Couto I, Portugal I, Martins M, et al. Ion channel blockers as antimicrobial agents, efflux inhibitors, and enhancers of macrophage killing activity against drug resistant mycobacterium tuberculosis. PLoS ONE. 2016;11(2).
  • Madeira MS, Pires VMR, Alfaia CM, Lopes PA, Martins SV, Pinto RMA, et al. Restriction of dietary protein does not promote hepatic lipogenesis in lean or fatty pigs. British Journal of Nutrition. 2016;115(8):1339–51.
  • Madureira AM, Vieira AJSC, Ferreira MJU. Caffeine extraction from tea and coffee. In: Comprehensive Organic Chemistry Experiments for the Laboratory Classroom. London: Royal Society of Chemistry; 2016. p. 30–4.
  • Magalhaes A, Matias I, Palmela I, Brito MA, Dias S. LDL-cholesterol increases the transcytosis of molecules through endothelial monolayers. PLoS ONE. 2016;11(10).
  • Magalhães LM, Machado S, Segundo MA, Lopes JA, Páscoa RNMJ. Rapid assessment of bioactive phenolics and methylxanthines in spent coffee grounds by FT-NIR spectroscopy. Talanta. 2016;147:460–7.
  • Marcos PM. Functionalization and properties of homooxacalixarenes. In: Calixarenes and Beyond. Cham, Basel: Springer; 2016. p. 445–66.
  • Martins E, Rodrigues CAB, Afonso CAM. Conversion of Alcohols into alkyl chlorides using cyanuric chloride. In: Comprehensive Organic Chemistry Experiments for the Laboratory Classroom. London: Royal Society of Chemistry; 2016. p. 76–9.
  • Marto J, Ascenso A, Simoes S, Almeida AJ, Ribeiro HM. Pickering emulsions: challenges and opportunities in topical delivery. Expert Opinion on Drug Delivery. 2016;13(8):1093–107.
  • Marto J, Gouveia LF, Goncalves LM, Gaspar DP, Pinto P, Carvalho FA, et al. A Quality by design (QbD) approach on starch-based nanocapsules: A promising platform for topical drug delivery. Colloids and Surfaces B-Biointerfaces. 2016 Jul;143:177–85.
  • Marto J, Jorge I, Almeida A, Ribeiro H. Novel starch-derived topical delivery systems. In: Carrier-Mediated Dermal Delivery: Applications in the Prevention and Treatment of Skin Disorders. Singapore: Pan Stanford; 2016. p. 175–216.
  • Marto J, Vitor C, Guerreiro A, Severino C, Eleuterio C, Ascenso A, et al. Ethosomes for enhanced skin delivery of griseofulvin. Colloids and Surfaces B-Biointerfaces. 2016;146:616–23.
  • Mata A, Ferreira JP, Semedo C, Serra T, Duarte CMM, Bronze MR. Contribution to the characterization of Opuntia spp. juices by LC-DAD-ESI-MS/MS. Food Chemistry. 2016;210:558–65.
  • Mata AT, Jorge TF, Ferreira J, do Rosário Bronze M, Branco D, Fevereiro P, et al. Analysis of low abundant trehalose-6-phosphate and related metabolites in Medicago truncatula by hydrophilic interaction liquid chromatography–triple quadrupole mass spectrometry. Journal of Chromatography A. 2016;1477:30–8.
  • Matias AA, Rosado-Ramos R, Nunes SL, Figueira I, Serra AT, Bronze MR, et al. Protective Effect of a (Poly)phenol-Rich Extract Derived from Sweet Cherries Culls against Oxidative Cell Damage. Molecules. 2016;21(4).
  • Meirinhos A, Siopa F, Afonso CAM. Hydroxyl Group Protection via Tetrahydropyranyl Ether formation. In: Comprehensive Organic Chemistry Experiments for the Laboratory Classroom. London: Royal Society of Chemistry; 2016. p. 241–3.
  • Morel T, Lhoir A, Picavet E, Mariz S, Sepodes B, Llinares J, et al. The orphan drug pipeline in Europe. Nature Reviews Drug Discovery. 2016;15(6):376.
  • Mégraud F, Lehours P, Vale FF. The history of Helicobacter pylori: from phylogeography to paleomicrobiology. Clinical Microbiology and Infection. 2016;22(11):922–7.
  • Noronha H, Araujo D, Conde C, Martins AP, Soveral G, Chaumont F, et al. The Grapevine Uncharacterized Intrinsic Protein 1 (VvXIP1) Is Regulated by Drought Stress and Transports Glycerol, Hydrogen Peroxide, Heavy Metals but Not Water. PLOS One. 2016;11(8).
  • Nunes-da-Cunha I, Arguello B, Martinez Martinez F, Fernandez-Llimos F. A Comparison of Patient-Centered Care in Pharmacy Curricula in the United States and Europe. American Journal of Pharmaceutical Education. 2016;80(5).
  • Nunes-da-Cunha I, Fernandez-Llimos F. Systematic coding of pharmacy practice educational contents. Pharmaceutical Care Espana. 2016;18(1):28–42.
  • Oliveira RF, Cabral Marques HM, Machado A V, Teixeira JC, Teixeira SF. VHC performance evaluation at constant flow: 30 L/Min. In: Proceedings of the ASME International Mechanical Engineering Congress And Exposition, 2015, Vol 3. New York: Amer Soc Mechanical Engineers; 2016.
  • Oliveira Silva C, Molpeceres J, Batanero B, Fernandes AS, Saraiva N, Costa JG, et al. Functionalized diterpene parvifloron D-loaded hybrid nanoparticles for targeted delivery in melanoma therapy. Therapeutic Delivery. 2016;7(8):521–44.
  • Otvagina KV, Mochalova AE, Sazanova TS, Petukhov AN, Moskvichev AA, Vorotyntsev AV, et al. Preparation and characterization of facilitated transport membranes composed of chitosan-styrene and chitosan-acrylonitrile copolymers modified by methylimidazolium based ionic liquids for CO2 separation from CH4 and N2. Membranes. 2016;6(2).
  • Perdigão P, Gaj T, Santa-Marta M, Barbas CF, Goncalves J. Reactivation of latent HIV-1 expression by engineered TALE transcription factors. PLoS ONE. 2016;11(3).
  • Pontes C, Alves M, Santos C, Ribeiro MH, Gonçalves L, Bettencourt AF, et al. Can Sophorolipids prevent biofilm formation on silicone catheter tubes? International Journal of Pharmaceutics. 2016;513(1–2):697–708.
  • Prieto-Davó A, Dias T, Gomes SE, Rodrigues S, Parera-Valadez Y, Borralho PM, et al. The madeira archipelago as a significant source of marine-derived actinomycete diversity with anticancer and antimicrobial potential. Frontiers in Microbiology. 2016;7(OCT).
  • Proença S, Cipriano M, Cabral MF, Costa J, Fernandes AS, Castro M, et al. Effect of MMP inhibitors on the migration of breast cancer cells. Toxicology Letters. 2016;258(S):S141–2.
  • Ramalhete C, Mulhovo S, Molnar J, Ferreira M-JU. Triterpenoids from Momordica balsamina: Reversal of ABCB1-mediated multidrug resistance. Bioorganic and Medicinal Chemistry. 2016;24(21):5061–7.
  • Ramalhete N, Machado A, Serrano R, Gomes ET, Mota-Filipe H, Silva O. Comparative study on the in vivo antidepressant activities of the Portuguese Hypericum foliosum, Hypericum androsaemum and Hypericum perforatum medicinal plants. Industrial Crops and Products. 2016;82:29–36.
  • Ramalhinho IMPS, Magalhaes J, Pinho S, Ataide Ferreira J, Cavaco A, Mota Filipe H, et al. Urinary tract infections: outpatient antibiotic use and antimicrobial resistance in the Algarve Region. International Journal of Clinical Pharmacy. 2016;38(2):564.
  • Reis W, Lombardi N, Vilela F, Fernandez-Llimos F, Correr C. Regulatory differences among Brazilian, European and American official drug labelling. International Journal of Clinical Pharmacy. 2016;38(2):512.
  • Ressurreição A, Perry MJ, Francisco A, Lopes F. Synthesis of Hippuric Acid: An Example of Amide Bond Formation. In: Comprehensive Organic Chemistry Experiments for the Laboratory Classroom. London: Royal Society of Chemistry; 2016. p. 147–50.
  • Ribeiro C, Moreira R, Santos MMM. Synthesis of a spiroisoxazoline oxindole by 1,3-dipolar Cycloaddition. In: Comprehensive Organic Chemistry Experiments for the Laboratory Classroom. London: Royal Society of Chemistry; 2016. p. 681–4.
  • Rodrigues CAB, Martinho J, Afonso CAM. Synthesis of a Biologically Active Oxazol-5(4H)-One via Erlenmeyer-Plöchl Reaction. In: Comprehensive Organic Chemistry Experiments for the Laboratory Classroom. London: Royal Society of Chemistry; 2016. p. 391–5.
  • Rodrigues J, Tato-Marinho R, Mota-Filipe H, Martins AP, Martins JC, Andreozzi V, et al. Evidence of Impressive Realworld SVR from the Portuguese Ledipasvir/Sofosbuvir and Sofosbuvir Universal Coverage Program to Eradicate (Eliminate) Hepatitis C. Journal of Hepatology. 2016;64(2):S224.
  • Rodrigues PM, Afonso MB, Simao AL, Caridade M, Carvalho CC, Trindade A, et al. MIR-21 Inhibition and Obeticholic Acid Ameliorate Non-Alcoholic Steatohepatitis In Dietary Animal Models. Journal of Hepatology. 2016;64(2):S681–2.
  • Rosatella AA, Afonso CAM. Organocatalysed trans-Dihydroxylation of Olefins. In: Comprehensive Organic Chemistry Experiments for the Laboratory Classroom. London: Royal Society of Chemistry; 2016. p. 769–72.
  • Rosatella AA, Afonso CAM. The dissolution of biomass in ionic liquids towards pre-treatment approach. In: Ionic Liquids in the Biorefinery Concept : Challenges and Perspectives. London: RSC Green Chemistry; 2016. p. 38–64.
  • Sabater-Hernandez D, Moullin JC, Hossain LN, Durks D, Franco-Trigo L, Fernandez-Llimos F, et al. Intervention mapping for developing pharmacy-based services and health programs: A theoretical approach. American Journal of Health-System Pharmacy. 2016;73(3):156–64.
  • Sainz V, Peres C, Ciman T, Rodrigues C, Viana AS, Afonso CAM, et al. Optimization of protein loaded PLGA nanoparticle manufacturing parameters following a quality-by-design approach. RSC Advances. 2016;6(106):104502–12.
  • Salústio P, Miguel M, Cabral-Marques H. Molecular (Cyclodextrin) Encapsulation of Volatiles and Essential Oils. In: Handbook of Encapsulation and Controlled Release. Boca Raton: CRC Press (Taylor & Francis); 2016. p. 867–906.
  • Santos CA, Pascoa RNMJ, Porto PALS, Cerdeira AL, Lopes JA. Application of Fourier-transform infrared spectroscopy for the determination of chloride and sulfate in wines. LWT-Food Science and Technology. 2016;67:181–6.
  • Santos FMF, Rosa JN, Candeias NR, Carvalho CP, Matos AI, Ventura AE, et al. A Three-Component Assembly Promoted by Boronic Acids Delivers a Modular Fluorophore Platform (BASHY Dyes). Chemistry - A European Journal. 2016;22(44).
  • Santos FMF, Rosa JN, Candeias NR, Carvalho CP, Matos AI, Ventura AE, et al. A Three-Component Assembly Promoted by Boronic Acids Delivers a Modular Fluorophore Platform (BASHY Dyes). Chemistry - A European Journal. 2016;22(5):1631–7.
  • Silva LJG, Martins MC, Pereira AMPT, Meisel LM, Gonzalez-Rey M, Bebianno MJ, et al. Uptake, accumulation and metabolization of the antidepressant fluoxetine by Mytilus galloprovincialis. Environmental Pollution. 2016;213:432–7.
  • Silva S, Tobaldini-Valerio F, Costa-De-Oliveira S, Henriques M, Azeredo J, Ferreira EC, et al. Discrimination of clinically relevant: Candida species by Fourier-transform infrared spectroscopy with attenuated total reflectance (FTIR-ATR). RSC Advances. 2016;6(94):92065–72.
  • Simeonov SP, Afonso CAM. Basicity and stability of urea deep eutectic mixtures. RSC Advances. 2016;6(7):5485–90.
  • Simeonov SP, Coelho JAS, Afonso CAM. Synthesis of 5-(Hydroxymethyl)furfural (HMF). Organic Syntheses. 2016. 29-36 p.
  • Soares J, Raimundo L, Pereira NAL, Monteiro Â, Gomes S, Bessa C, et al. Reactivation of wild-type and mutant p53 by tryptophanolderived oxazoloisoindolinone SLMP53-1, a novel anticancer small-molecule. Oncotarget. 2016;7(4):4326–43.
  • Solo-Gabriele HM, Harwood VJ, Kay D, Fujioka RS, Sadowsky MJ, Whitman RL, et al. Beach sand and the potential for infectious disease transmission: Observations and recommendations. Journal of the Marine Biological Association of the United Kingdom. 2016;96(1):101–20.
  • Sousa M, Machado V, Costa R, Figueira ME, Sepodes B, Barata P, et al. Red Raspberry Phenols Inhibit Angiogenesis: A Morphological and Subcellular Analysis Upon Human Endothelial Cells. Journal of Cellular Biochemistry. 2016;117(7):1604–12.
  • Sousa ME, Araújo MJ, Vale ML, Andrade PB, Branco P, Gomes P, et al. 11thnational meeting of organic chemistry and 4th meeting of therapeutic chemistry. Pharmaceuticals. 2016;9(1).
  • Talotta C, Gaeta C, De Rosa M, Ascenso JR, Marcos PM, Neri P. Alkylammonium Guest Induced-Fit Recognition by a Flexible Dihomooxacalix[4]arene Derivative. European Journal of Organic Chemistry. 2016;2016(1):158–67.
  • Tonin FS, Wiens A, Fernandez-Llimos F, Pontarolo R. Iloperidone in the treatment of schizophrenia: An evidence-based review of its place in therapy. Core Evidence. 2016;11:49–61.
  • Valente E, Dias C, Constantino L. Acetylation of Cholesterol and Purification by Column Chromatography. In: Comprehensive Organic Chemistry Experiments for the Laboratory Classroom. London: Royal Society of Chemistry; 2016. p. 142–6.
  • van der Laan JW, Kasper P, Silva Lima B, Jones DR, Pasanen M. Critical analysis of carcinogenicity study outcomes. Relationship with pharmacological properties. Critical Reviews in Toxicology. 2016;46(7):587–614.
  • Vaz A, Gomes C, Cunha C, Brites D. Astrocytes in Amyotrophic Lateral Sclerosis: Harmful Effects and Strategies to Afford Neuroprotection. In: New Developments in Astrocytes Research. New York: Nova Science Publishers; 2016. p. 67–111.
  • Ventura A, Santos T, Carreira A, Martinho N, Conniot J, Varela A, et al. Drugs, delivery systems and membrane organization in model and cell membranes. In: Membrane organization and lipid rafts in the cell and artificial membranes. New York: Nova Science Publishers; 2016. p. 53–88.
  • Vicente A, Afonso CAM. Regioselective epoxidation of geraniol by VO(acac)2 Immobilised in Polystyrene. In: Comprehensive Organic Chemistry Experiments for the Laboratory Classroom. London: Royal Society of Chemistry; 2016. p. 766–8.
  • Vicente A, Afonso CAM. Regioselective N-alkylation of adenine by nucleophilic substitution. In: Comprehensive Organic Chemistry Experiments for the Laboratory Classroom. London: Royal Society of Chemistry; 2016. p. 92–4.
  • Wilks MF, Blaauboer BJ, Schulte-Hermann R, Wallace HM, Galli CL, Haag-Gronlund M, et al. The European Registered Toxicologist (ERT): Current status and prospects for advancement. Toxicology Letters. 2016;259:151–5.
  • Xavier JM, Rodrigues CMP, Solá S. Mitochondria: Major Regulators of Neural Development. Neuroscientist. 2016;22(4):346–58.
  • Zupančič E, Peres C, Matos AI, Lopes J, Moreira JN, Gaspar RS, et al. Translational peptide-associated nanosystems: Promising role as cancer vaccines. Current Topics in Medicinal Chemistry. 2016;16(3):291–313.

Honorable Mention of the APRH Award 2014/15
Best analytical poster at the “Spring Conference: Phytochemicals, health & plant based nutrition, Nutrition Society 2016”
OIV Award 2016 in the Oenology category


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