Toxicological and Bromatological Sciences

Main Activities

Teaching of 1st, 2nd and 3rd cycles.
Scientific research and technological development.
University extension services:
            services to community
            outreach activities in the field of continuous education and the promotion of innovation.


Head of Department
Maria do Rosário Beja de Figueiredo Gonzaga Bronze

Executive Committee
Ana Paula Marreilha
Cristina Carvalho
Judite Costa
Lídia Pinheiro
Maria Eduardo Figueira

Department Committee
The Department Committee is constituted by DCTB Doctors linked to FFUL.


Research Institute for Medicines (iMed.ULisboa)
Research Groups:
            Chemical Biology and Toxicology
            Natural Products Chemistry
            Pharmacological and Regulatory Sciences

Institute of Experimental and Technological Biology (iBET)

Center for Botany Applied to Agriculture (Instituto Superior de Agronomia, ULisboa)




  • Andrade VM, Aschner M, Marreilha dos Santos AP. Neurotoxicity of Metal Mixtures. In: Michael AschnerLucio G. Costa, editor. Neurotoxicity of Metals. Cham: Springer; 2017. p. 227–65.
  • Anes E. Acting on Actin During Bacterial Infection. In: Jose C. Jimenez-Lopez, editor. Cytoskeleton - Structure, Dynamics, Function and Disease. London: InTech; 2017. p. 257–78.
  • Bettencourt P, Carmo N, Pires D, Timóteo P, Anes E. Mycobacterial infection of macrophages: the effect of the multiplicity of infection. In: Antimicrobial Research: Novel bioknowledge and educational programs. Badajóz: Formatex Research Center;
  • Gregorí Valdes BS, Vilela CCM, Ascenso A, Bordado JM RH. Topical formulations for onychomycosis: a review. In: Ascenso A, Ribeiro HM, Simões S, editors. Carrier-Mediated Dermal Delivery: Applications in the Prevention and Treatment of Skin Disorders. Singapore: Pan Stanford; 2017. p. 503–53.
  • Ismaili L, Romero A, Carreiras MC, Marco-Contelles J. Multitarget-Directed Antioxidants as Therapeutic Agents. In: Michael Decker, editor. Design of Hybrid Molecules for Drug Development. Amsterdam: Elsevier; 2017. p. 5–46.
  • Lambricht L, Peres C, Florindo H, Préat V, Vandermeulen G. Polymer-Based Nanoparticles as Modern Vaccine Delivery Systems. In: Skwarczynski M, Toth I, editors. Micro and Nanotechnology in Vaccine Development. Oxford: William Andrew Publishing; 2017. p. 185–203.
  • Lana J, Ascenso A. New Trends in Anti-Aging Skin Care. In: Ascenso A, Ribeiro HM, Simões S, editors. Carrier-Mediated Dermal Delivery: Applications in the Prevention and Treatment of Skin Disorders. Singapore: Pan Stanford; 2017. p. 3–41.
  • Malmir M, Serrano R, Silva O. Anthraquinones as potential antimicrobial agents-A review. In: A. Méndez-Vilas, editor. Antimicrobial research: Novel bioknowledge and educational programs. Badajoz: Formatex Research Center; 2017. p. 55-61.
  • Manteigas P, Ascenso A. Melatonin: a “guardian” of the genome and cellular integrity for prevention of photocarcinogenesis. In: Ascenso A, Ribeiro HM, Simões S, editors. Carrier-Mediated Dermal Delivery: Applications in the Prevention and Treatment of Skin Disorders. Singapore: Pan Stanford; 2017. p. 43–90.
  • Marto J, Jorge I, Almeida A, Ribeiro H. Novel starch-derived topical delivery systems. In: Ascenso A, Ribeiro H, Simões S, editors. Carrier-Mediated Dermal Delivery: Applications in the Prevention and Treatment of Skin Disorders. Singapore: Pan Stanford; 2017. p. 175–216.
  • Mendes T, Gaspar M, Simões S, Ascenso A. Lipid Vesicles for Skin Delivery: Evolution from first generation. In: Ascenso A, Ribeiro HM, Simões S, editors. Carrier-Mediated Dermal Delivery: Applications in the Prevention and Treatment of Skin Disorders. Singapore: Pan Stanford; 2017. p. 281–321.
  • Nunes A, Ramalho R, Rodrigues CMP. Morte celular no sistema nervoso. In: Rego AC, Duarte CB, Oliveira CR, editors. Neurociências. Lisboa: Lidel; 2017. p. 499–512.
  • Paulo A, Castillo C, Neidle S. Targeting Promoter Quadruplex Nucleic Acids for Cancer Therapy. In: Chackalamannil S, Rotella D, Ward S, editors. Comprehensive medicinal chemistry III. Amsterdam: Elsevier; 2017. p. 308–40.
  • Pinheiro L, Faustino C. Amino Acid-Based Surfactants for Biomedical Applications. In: Reza Najjar, editor. Application and Characterization of Surfactants. London: InTech; 2017.
  • Pires C, Cavaco A, Vigario M. How sociodemographic features impact subjects’ opinion on packages leaflets of medicines? Australasian Medical Journal. 2017;10(9):774–84
  • Pires C, Cavaco A, Vigário M. Towards the Definition of Linguistic Metrics for Evaluating Text Readability. Journal of Quantitative Linguistics. 2017;24(4):319–49
  • Pires C, Martins F, Cavaco A, Vigário M. Automatic quantification of abbreviations in medicine package leaflets and their comprehension assessment. International Journal of E-Health and Medical Communications. 2017;8(2):47–64
  • Pires C, Vigário M, Cavaco A. Evaluation of the type and structure of the imprints used on the surface of medicines. Journal of Pharmacy Practice and Research. 2017;47(1):23–6
  • Pires D, Bernard EM, Pombo JP, Carmo N, Fialho C, Gutierrez MG, et al. Mycobacterium tuberculosis modulates miR-106b-5p to control Cathepsin S expression resulting in higher pathogen survival and poor T-cell activation. Frontiers in Immunology. 2017;8(DEC)
  • Polsinelli B, Tsigkos S, Naumann-Winter F, Mariz S, Sepodes B. Evolving prevalence of haematological malignancies in orphan designation procedures in the European Union. Orphanet Journal of Rare Diseases. 2017;12(1)
  • Pontes da Costa A, Nunes DR, Tharaud M, Oble J, Poli G, Rieger J. Palladium(0) Nanoparticles Embedded in Core–shell Nanogels as Recoverable Catalysts for the Mizoroki–Heck Reaction. ChemCatChem. 2017;9(12):2167–75
  • Raaf N, Amhis W, Saoula H, Abid A, Nakmouche M, Balamane A, et al. Prevalence, antibiotic resistance, and MLST typing of Helicobacter pylori in Algiers, Algeria. Helicobacter. 2017;22(6)
  • Raposo LR, Roma-Rodrigues C, Faísca P, Alves M, Henriques J, Carvalheiro MC, et al. Immortalization and characterization of a new canine mammary tumour cell line FR37-CMT. Veterinary and Comparative Oncology. 2017;15(3):952–67
  • Ravasco JMJM, Coelho JAS, Simeonov SP, Afonso CAM. Bifunctional Cr3+modified ion exchange resins as efficient reusable catalysts for the production and isolation of 5-hydroxymethylfurfural from glucose. RSC Advances. 2017;7(13):7555–9
  • Ravasco JMJM, Monteiro CM, Trindade AF. Cyclopropenes: A new tool for the study of biological systems. Organic Chemistry Frontiers. 2017;4(6):1167–98
  • Rebelo A, Molpeceres J, Rijo P, Reis CP. Pancreatic cancer therapy review: From classic therapeutic agents to modern nanotechnologies. Current Drug Metabolism. 2017;18(4):346–59
  • Reis C, Antunes AF, Pereira P, Reis C, Rijo P. Nanosystems for skin delivery: From drugs to cosmetics. Current Drug Metabolism. 2017;18(5):412–25
  • Reis CP, Neufeld RJ, Veiga F, Ribeiro AJ, Neufeld RJ, Veiga F, et al. Preparation of Drug-Loaded Polymeric Nanoparticles. In: Lajos P Balogh, editor. Nanomedicine in Cancer. Singapore: Pan Stanford; 2017. p. 171–214.
  • Reis MA, Ahmed OB, Spengler G, Molnár J, Lage H, Ferreira M-JU. Exploring Jolkinol D Derivatives to Overcome Multidrug Resistance in Cancer. Journal of Natural Products. 2017;80(5):1411–20
  • Reis WC, Bonetti AF, Bottacin WE, Reis AS, Souza TT, Pontarolo R, et al. Impact on process results of clinical decision support systems (CDSSS) applied to medication use: Overview of systematic reviews. Pharmacy Practice. 2017;15(4)
  • Reis-Pardal J, Rodrigues A, Rodrigues E, Fernandez-Llimos F. Comparing cytochrome P450 pharmacogenetic information available on United States drug labels and European Union Summaries of Product Characteristics. Pharmacogenomics Journal. 2017;17(6):488–93
  • Ren X, Zou L, Zhang X, Branco V, Wang J, Carvalho C, et al. Redox Signaling Mediated by Thioredoxin and Glutathione Systems in the Central Nervous System. Antioxidants and Redox Signaling. 2017;27(13):989–1010
  • Resende AP, Silva B, Braz BS, Nunes T, Gonçalves L, Delgado E. Ex vivo permeation of erythropoietin through porcine conjunctiva, cornea, and sclera. Drug Delivery and Translational Research. 2017;7(5):625–31
  • Restolho J, Barroso M, Saramago B, Dias M, Afonso CAM. Contactless decontamination of hair samples: cannabinoids. Drug Testing and Analysis. 2017;9(2):282–8
  • Rezayan AH, Hariri S, Azerang P, Ghavami G, Portugal I, Sardari S. Synthesis of novel fluorene bisamide derivatives via ugi reaction and evaluation their biological activity against Mycobacterium species. Iranian Journal of Pharmaceutical Research. 2017;16(2):724–52
  • Ribeiro CJA, Nunes RC, Amaral JD, Gonçalves LM, Rodrigues CMP, Moreira R, et al. Spirotriazoline oxindoles: A novel chemical scaffold with in vitro anticancer properties. European Journal of Medicinal Chemistry. 2017;140:494–509
  • Rocha C, Duarte J, Borrego P, Calado R, Marcelino JM, Tendeiro R, et al. Potency of HIV-2-specific antibodies increase in direct association with loss of memory B cells. AIDS. 2017;31(17):2431–3
  • Rocha Â, Teixeira R, Lourenço NMT, Afonso CAM. Enzymatic Kinetic Resolution of Secondary Alcohols Using an Ionic Anhydride Generated In Situ. ChemSusChem. 2017;10(1):296–302
  • Rodrigues C, Novais Â, Sousa C, Ramos H, Coque TM, Cantón R, et al. Elucidating constraints for differentiation of major human Klebsiella pneumoniae clones using MALDI-TOF MS. European Journal of Clinical Microbiology and Infectious Diseases. 2017;36(2):379–86
  • Rodrigues C, Tartaro Bujak I, Mihaljević B, Soveral G, Cipak Gasparovic A. Yeast aquaporin regulation by 4-hydroxynonenal is implicated in oxidative stress response. IUBMB Life. 2017;69(5):355–62
  • Rodrigues CAB, Misale A, Schiel F, Maulide N. Direct synthesis of γ-pyrones by electrophilic condensation of β-ketoesters. Organic and Biomolecular Chemistry. 2017;15(3):680–3
  • Rodrigues LM, Palma L, Santos O, Almeida MA, Bujan J, Tavares L. Excessive Weight Favours Skin Physiology - Up to a Point: Another Expression of the Obesity Paradox. Skin Pharmacology and Physiology. 2017;30(2):94–101
  • Rodrigues PM, Afonso MB, Simaõ AL, Carvalho CC, Trindade A, Duarte A, et al. MiR-21 ablation and obeticholic acid ameliorate nonalcoholic steatohepatitis in mice. Cell Death and Disease. 2017;8(4)
  • Rolim I, Duarte N, Barata G, Costa J, Gardete-Correia L, Boavida J, et al. Immunoglobulin M gene association with autoantibody reactivity and type 1 diabetes. Immunogenetics. 2017;69(7):429–37
  • Romero-Severson EO, Bulla I, Hengartner N, Bartolo I, Abecasis A, Azevedo-Pereira JM, et al. Donor-Recipient Identification in Para- and Poly-phyletic Trees Under Alternative HIV-1 Transmission Hypotheses Using Approximate Bayesian Computation. Genetics. 2017 Nov;207(3):1089–101
  • Roque L, Molpeceres J, Reis C, Rijo P, Reis CP. Past, recent progresses and future perspectives of nanotechnology applied to antifungal agents. Current Drug Metabolism. 2017;18(4):280–90
  • Roque LV, Dias IS, Cruz N, Rebelo A, Roberto A, Rijo P, et al. Design of Finasteride-Loaded Nanoparticles for Potential Treatment of Alopecia. Skin Pharmacology and Physiology. 2017;30(4):197–204
  • Rosa AI, Fonseca I, Nunes MJ, Moreira S, Rodrigues E, Carvalho AN, et al. Novel insights into the antioxidant role of tauroursodeoxycholic acid in experimental models of Parkinson’s disease. Biochimica et Biophysica Acta - Molecular Basis of Disease. 2017;1863(9):2171–81
  • Rosado C, Antunes F, Barbosa R, Fernando R, Estudante M, Silva HN, et al. About the in vivo quantitation of skin anisotropy. Skin Research and Technology. 2017;23(3):429–36
  • Rotta I, Souza TT, Salgado TM, Correr CJ, Fernandez-Llimos F. Characterization of published randomized controlled trials assessing clinical pharmacy services around the world. Research In Social & Administrative Pharmacy. 2017;13(1):201–8
  • Saldanha Do Carmo C, Maia C, Poejo J, Lychko I, Gamito P, Nogueira I, et al. Microencapsulation of α-tocopherol with zein and β-cyclodextrin using spray drying for colour stability and shelf-life improvement of fruit beverages. RSC Advances. 2017;7(51):32065–75
  • Santos CAT, Páscoa RNMJ, Lopes JA. Applications of FTIR Spectroscopy in the Wine Industry. In: Moore E, editor. Fourier transform infrared spectroscopy (FTIR) : methods, analysis, and research insights. New York: Nova Science Publishers; 2017. p. 79–120.
  • Santos DM, Aschner M, Santos APM. Manganese and Neurodegeneration. In: Anthony R. White MA, Lucio G. Costa, Ashley I. Bush, editors. Biometals in Neurodegenerative Diseases. London: Academic Press; 2017. p. 117–51.
  • Santos FMF, Matos AI, Ventura AE, Gonçalves J, Veiros LF, Florindo HF, et al. Modular Assembly of Reversible Multivalent Cancer-Cell-Targeting Drug Conjugates. Angewandte Chemie - International Edition. 2017;56(32):9346–50
  • Santos T, Ferreira R, Quartin E, Boto C, Saraiva C, Bragança J, et al. Blue light potentiates neurogenesis induced by retinoic acid-loaded responsive nanoparticles. Acta Biomaterialia. 2017;59:293–302
  • Scapin E, Frizzo CP, Rodrigues LV, Zimmer GC, Vaucher RA, Sagrillo MR, et al. Synthesis, antimicrobial activity and cytotoxic investigation of novel trifluoromethylated tetrazolo[1,5-a]pyrimidines. Medicinal Chemistry Research. 2017;26(3):640–9
  • Scomparin A, Florindo HF, Tiram G, Ferguson EL, Satchi-Fainaro R. Two-step polymer- and liposome-enzyme prodrug therapies for cancer: PDEPT and PELT concepts and future perspectives. Advanced Drug Delivery Reviews. 2017;118:52–64
  • Shamsabadi A, Ren J, Chudasama V. Enabling the facile conversion of acyl hydrazides into: N -acyl carbamates via metal-free ionic-based rupture of the N-N linkage. RSC Advances. 2017;7(44):27608–11
  • Silva AF, Sarraguça MC, Fonteyne M, Vercruysse J, De Leersnyder F, Vanhoorne V, et al. Multivariate statistical process control of a continuous pharmaceutical twin-screw granulation and fluid bed drying process. International Journal of Pharmaceutics. 2017;528(1–2):242–52
  • Silva AFT, Sarraguça MC, Ribeiro PR, Santos AO, De Beer T, Lopes JA. Statistical process control of cocrystallization processes: A comparison between OPLS and PLS. International Journal of Pharmaceutics. 2017;520(1–2):29–38
  • Silva AL, Peres C, Conniot J, Matos AI, Moura L, Carreira B, et al. Nanoparticle impact on innate immune cell pattern-recognition receptors and inflammasomes activation. Seminars In Immunology. 2017;34(C):3–24
  • Silva AS, Quintelas C, Ferreira EC, Lopes JA, Sousa C. Exploiting intrinsic fluorescence spectroscopy to discriminate between Acinetobacter calcoaceticus-Acinetobacter baumannii complex species. RSC Advances. 2017;7(14):8581–8
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  • Silva FC, Marto JM, Salgado A, Machado P, Silva AN, Almeida AJ. Nystatin and lidocaine pastilles for the local treatment of oral mucositis. Pharmaceutical Development and Technology. 2017;22(2):266–74
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  • Silva MM, Calado R, Marto J, Bettencourt A, Almeida AJ, Gonçalves LMD. Chitosan nanoparticles as a mucoadhesive drug delivery system for ocular administration. Marine Drugs. 2017;15(12)
  • Silva O, Serrano R. Micromorphological studies for application in the quality control of herbal medicines-some data of plants used in Mozambique. In: Méndez-Vilas A, editor. Microscopy and imaging science: practical approaches to applied research and education. Badajoz: Formatex Research Center; 2017. p. 231–6.
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  • Teixeira dos Santos CA, Páscoa RNMJ, Sarraguça MC, Porto PALS, Cerdeira AL, González-Sáiz JM, et al. Merging vibrational spectroscopic data for wine classification according to the geographic origin. Food Research International. 2017;102:504–10
  • Teixeira FA, Marcos PM, Ascenso JR, Brancatelli G, Hickey N, Geremia S. Selective Binding of Spherical and Linear Anions by Tetraphenyl(thio)urea-Based Dihomooxacalix[4]arene Receptors. Journal of Organic Chemistry. 2017;82(21):11383–90
  • Tenreiro MM, Correia ML, Brito MA. Endothelial progenitor cells in multiple myeloma neovascularization: a brick to the wall. Angiogenesis. 2017;20(4):443–62
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  • Vicente AI, Esteves T, Afonso CAM, Ferreira FC. Solvent compatible polymer functionalization with adenine, a DNA base, for API degenotoxification: Preparation and characterization. Separation and Purification Technology. 2017;179:438–48
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  • Vitorino C, Almeida AJ. Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) as topical delivery systems for antioxidants. In: Ascenso A, Ribeiro HM, Simões S, editors. Carrier-Mediated Dermal Delivery: Applications in the Prevention and Treatment of Skin Disorders. Singapore: Pan Stanford; 2017. p. 217–63.
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  • Bandarra NM, Lopes PA, Martins SV, Ferreira J, Alfaia CM, Rolo EA, et al. Docosahexaenoic acid at the sn-2 position of structured triacylglycerols improved n-3 polyunsaturated fatty acid assimilation in tissues of hamsters. Nutrition Research. 2016;36(5):452–63.
  • Baptista PM, Moran EC, Vyas D, Ribeiro MH, Atala A, Sparks JL, et al. Fluid flow regulation of revascularization and cellular organization in a bioengineered liver platform. Tissue Engineering - Part C: Methods. 2016;22(3):199–207.
  • Baptista R, Ferreira RJ, Dos Santos DJVA, Fernandes MX, Ferreira M-JU. Optimizing the macrocyclic diterpenic core toward the reversal of multidrug resistance in cancer. Future Medicinal Chemistry. 2016;8(6):629–45.
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  • Beloqui A, Solinís MÁ, Rodríguez-Gascón A, Almeida AJ, Préat V. Nanostructured lipid carriers: Promising drug delivery systems for future clinics. Nanomedicine: Nanotechnology, Biology, and Medicine. 2016;12(1):143–61.
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  • Candeias NR, Paterna R, Gois PMP. Homologation Reaction of Ketones with Diazo Compounds. Chemical Reviews. 2016;116(5):2937–81.
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Honorable Mention of the APRH Award 2014/15
Best analytical poster at the “Spring Conference: Phytochemicals, health & plant based nutrition, Nutrition Society 2016”
OIV Award 2016 in the Oenology category


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