Ciências Toxicológicas e Bromatológicas

Principais Atividades

Ensino de 1.º, 2.º e 3.º ciclos.
Investigação científica e desenvolvimento tecnológico.
Serviços de extensão universitária:
            serviços ao exterior
            atividades complementares no domínio da formação contínua e da promoção da inovação.


Maria do Rosário Beja de Figueiredo Gonzaga Bronze

Comissão Executiva
Ana Paula Marreilha
Cristina Carvalho
Judite Costa
Lídia Pinheiro
Maria Eduardo Figueira

Comissão de Departamento
A Comissão de Departamento é constituída pelos Doutores do DCTB com vínculo à FFUL


Instituto de Investigação do Medicamento (iMed.ULisboa)
Grupos de Investigação:
            Química Biológica e Toxicológica
            Química de Produtos Naturais
            Ciências Farmacológicas e Regulamentar

Instituto de Biologia Experimental e Tecnológica (iBET)

Centro de Botânica Aplicada à Agricultura (Instituto Superior de Agronomia da ULisboa)




  • Afonso MB, Rodrigues PM, Castro RE, Rodrigues CM. miRNAs as biomarkers and regulators of liver disease. European Journal Of Clinical Investigation. 2017;47(1, SI):19.
  • Afonso MB, Rodrigues PM, Simao AL, Gaspar MM, Castro RE, Rodrigues CMP. miRNA-21-deficiency reduces liver injury, fibrosis and necroptosis in cholestatic bile duct-ligated mice. Journal of Hepatology. 2017;66(1, S):S555.
  • Barateiro A, Mahú I, Domingos AI. Leptin resistance and the neuro-adipose connection. Frontiers in Endocrinology. 2017;8(MAR).
  • Branco V, Coppo L, Solá S, Lu J, Rodrigues CMP, Holmgren A, et al. Impaired cross-talk between the thioredoxin and glutathione systems is related to ASK-1 mediated apoptosis in neuronal cells exposed to mercury. Redox Biology. 2017;13:278–87.
  • Brites D, Monteiro M, Ribeiro AR, Cunha C, Vaz AR, Fernandes A. Role of neuron-microglia secretome and stress-related microRNAS in Alzheimer’s disease. Glia. 2017 Jun;65(1):E301–2.
  • Caldeira C, Cunha C, Vaz AR, Falcão AS, Barateiro A, Seixas E, et al. Key aging-associated alterations in primary microglia response to beta-amyloid stimulation. Frontiers in Aging Neuroscience. 2017;9.
  • Cantante C, Lourenço S, Morais M, Leandro J, Gano L, Silva N, et al. Albumin-binding domain from Streptococcus zooepidemicus protein Zag as a novel strategy to improve the half-life of therapeutic proteins. Journal of Biotechnology. 2017;253:23–33.
  • Carvalho AN, Firuzi O, Gama MJ, van Horssen J, Saso L. Oxidative Stress and Antioxidants in Neurological Diseases: Is There Still Hope? Current Drug Targets. 2017;18(6):705–18.
  • Castro RE, Rodrigues CMP. Cell death and microRNAs in cholestatic liver diseases: Update on potential therapeutic applications. Current Drug Targets. 2017;18(8):921–31.
  • Cavaco MC, Pereira C, Kreutzer B, Gouveia LF, Silva-Lima B, Brito AM, et al. Evading P-glycoprotein mediated-efflux chemoresistance using Solid Lipid Nanoparticles. European Journal of Pharmaceutics and Biopharmaceutics. 2017;110:76–84.
  • Coelho AI, Rubio-Gozalbo ME, Vicente JB, Rivera I. Sweet and sour: an update on classic galactosemia. Journal of Inherited Metabolic Disease. 2017;40(3):325–42.
  • Couto RAS, Goncalves LM, Goes MS, Rodrigues CMP, Beatriz Quinaz M, Rodrigues JA. SAM-Based Immunosensor for the Analysis of Thyroxine (T4). Journal of the Electrochemical Society. 2017;164(4):B103–6.
  • Custódio-Santos T, Videira M, Brito MA. Brain metastasization of breast cancer. Biochimica et Biophysica Acta - Reviews on Cancer. 2017;1868(1):132–47.
  • da Costa M, Bernardi J, Costa L, Fiuza T, Brandão R, Ribeiro MF, et al. N-acetylcysteine treatment attenuates the cognitive impairment and synaptic plasticity loss induced by streptozotocin. Chemico-Biological Interactions. 2017;272:37–46.
  • da Silva I, Rodrigues C, Barroso M, Moura T, Castro R, Soveral G. Biophysical assessment of endothelial aquaporins as water and glycerol channels. European Biophysics Journal with Biophysics Letters. 2017 Jul;46(1):S270.
  • De Almeida A, Mósca AF, Wragg D, Wenzel M, Kavanagh P, Barone G, et al. The mechanism of aquaporin inhibition by gold compounds elucidated by biophysical and computational methods. Chemical Communications. 2017;53(27):3830–3.
  • Direito I, Paulino J, Vigia E, Brito MA, Soveral G. Differential expression of aquaporin-3 and aquaporin-5 in pancreatic ductal adenocarcinoma. Journal of Surgical Oncology. 2017;115(8):980–96.
  • Direito R, Lima A, Rocha J, Ferreira RB, Mota J, Rebelo P, et al. Dyospiros kaki phenolics inhibit colitis and colon cancer cell proliferation, but not gelatinase activities. Journal of Nutritional Biochemistry. 2017;46:100–8.
  • Falcão AS, Carvalho LAR, Lidónio G, Vaz AR, Lucas SD, Moreira R, et al. Dipeptidyl Vinyl Sulfone as a Novel Chemical Tool to Inhibit HMGB1/NLRP3-Inflammasome and Inflamma-miRs in Aβ-Mediated Microglial Inflammation. ACS Chemical Neuroscience. 2017;8(1):89–99.
  • Fernandes A. Targeting in situ neuroinflammation inmultiple sclerosis. IRISH Journal Of Medical Science. 2017 Jul;186(7):S288.
  • Figueira I, Garcia G, Pimpão RC, Terrasso AP, Costa I, Almeida AF, et al. Polyphenols journey through blood-brain barrier towards neuronal protection. Scientific Reports. 2017;7(1).
  • Figueira I, Tavares L, Jardim C, Costa I, Terrasso AP, Almeida AF, et al. Blood-brain barrier transport and neuroprotective potential of blackberry-digested polyphenols: an in vitro study. European Journal of Nutrition. 2017;1–18.
  • Fonseca I, Gordino G, Moreira S, Nunes MJ, Azevedo C, Gama MJ, et al. Erratum to: Tauroursodeoxycholic Acid Protects Against Mitochondrial Dysfunction and Cell Death via Mitophagy in Human Neuroblastoma Cells (Molecular Neurobiology, (2017), 54, 8, (6107-6119), 10.1007/s12035-016-0145-3). Molecular Neurobiology. 2017;54(8):6120.
  • Fonseca I, Gordino G, Moreira S, Nunes MJ, Azevedo C, Gama MJ, et al. Tauroursodeoxycholic Acid Protects Against Mitochondrial Dysfunction and Cell Death via Mitophagy in Human Neuroblastoma Cells. Molecular Neurobiology. 2017;54(8):6107–19.
  • Freitas MA, Brites D, Bota A. Desensitization study of paclitaxel and carboplatin drug in the ovary tumor protocol in Cuf Descobertas Hospital. International Journal of Clinical Pharmacy. 2017;39(1):259.
  • Gama-Marques J, Tinoco I, Pedro I, Leote F, Ouakinin RSS. Unconjugated bilirubin and acute schizophrenia: A probable correlation? [Bilirrubina no conjugada y esquizofrenia aguda: ¿una correlación probable?] Actas Espanolas de Psiquiatria. 2017;45(2):79.
  • Garcia G, Nanni S, Figueira I, Ivanov I, McDougall GJ, Stewart D, et al. Bioaccessible (poly)phenol metabolites from raspberry protect neural cells from oxidative stress and attenuate microglia activation. Food Chemistry. 2017;215:274–83.
  • Leandro J, Saraste J, Leandro P, Flatmark T. PKU mutation p.G46S prevents the stereospecific binding of L-phenylalanine to the dimer of human phenylalanine hydroxylase regulatory domain. FEBS Open Bio. 2017;7(2):195–203.
  • Leandro J, Stokka AJ, Teigen K, Andersen OA, Flatmark T. Substituting Tyr(138) in the active site loop of human phenylalanine hydroxylase affects catalysis and substrate activation. FEBS Open Bio. 2017 Jul;7(7):1026–36.
  • Lopes PA, Martins AP, Martins SV, Madeira MS, Santos NC, Moura TF, et al. Higher membrane fluidity mediates the increased subcutaneous fatty acid content in pigs fed reduced protein diets. Animal. 2017;11(4):713–9
  • Marques F, Sousa JC, Brito MA, Pahnke J, Santos C, Correia-Neves M, et al. The choroid plexus in health and in disease: dialogues into and out of the brain. Neurobiology of Disease. 2017;107:32–40
  • Martins SV, Pires VMR, Madeira AP, Nascimento M, Alfaia CM, Castro MF, et al. Novel anti-adipogenic properties of the individual trans8,cis10 conjugated linoleic acid (CLA) isomer in 3T3-L1 adipocytes. European Journal of Lipid Science and Technology. 2017;119(2)
  • Moedas MF, Adam AAA, Farelo MA, IJlst L, Chamuleau RAFM, Hoekstra R, et al. Advances in methods for characterization of hepatic urea cycle enzymatic activity in HepaRG cells using UPLC-MS/MS. Analytical Biochemistry. 2017;535:47–55
  • Moreira S, Fonseca I, Nunes MJ, Rosa A, Lemos L, Rodrigues E, et al. Nrf2 activation by tauroursodeoxycholic acid in experimental models of Parkinson’s disease. Experimental Neurology. 2017;295:77–87
  • Morris AAM, Kozich V, Santra S, Andria G, Ben-Omran TIM, Chakrapani AB, et al. Guidelines for the diagnosis and management of cystathionine beta-synthase deficiency. Journal of Inherited Metabolic Disease. 2017 Jan;40(1):49–74
  • Mosca AF, de Almeida A, Rodrigues C, Casini A, Soveral G. Roles of Aquaporins in health and disease: promising targets for drug discovery. European Biophysics Journal with Biophysics Letters. 2017 Jul;46(1):S77.
  • Mosca AF, Rodrigues C, Martins AP, Prista C, Soveral G. Rat aquaporin-5 is pH-gated induced by phosphorylation. European Biophysics Journal with Biophysics Letters. 2017 Jul;46(1):S288.
  • Moutinho M, Nunes MJ, Rodrigues E. The mevalonate pathway in neurons: It’s not just about cholesterol. Experimental Cell Research. 2017;360(1):55–60
  • Méndez-Giménez L, Becerril S, Camões SP, Da Silva IV, Rodrigues C, Moncada R, et al. Role of aquaporin-7 in ghrelin-and GLP-1-induced improvement of pancreatic β-cell function after sleeve gastrectomy in obese rats. International Journal of Obesity. 2017;41(9):1394–402
  • Méndez-Giménez L, Becerril S, Moncada R, Valentí V, Fernández S, Ramírez B, et al. Gastric Plication Improves Glycemia Partly by Restoring the Altered Expression of Aquaglyceroporins in Adipose Tissue and the Liver in Obese Rats. Obesity Surgery. 2017;27(7):1763–74
  • Nunes A, Ramalho R, Rodrigues CMP. Morte celular no sistema nervoso. In: Rego AC, Duarte CB, Oliveira CR, editors. Neurociências. Lisboa: Lidel; 2017. p. 499–512.
  • Nunes RC, Ribeiro CJA, Monteiro Â, Rodrigues CMP, Amaral JD, Santos MMM. In vitro targeting of colon cancer cells using spiropyrazoline oxindoles. European Journal of Medicinal Chemistry. 2017;139:168–79
  • Oleastro M, Rocha R, Vale FF. Ancestry and spread of Portuguese Helicobacter pylori strains. Helicobacter. 2017;22(1, SI).
  • Oleastro M, Rocha R, Vale FF. Population genetic structure of Helicobacter pylori strains from Portuguese-speaking countries. Helicobacter. 2017;22(4)
  • Palmela C, Torres J, de Sena PG, Costa Santos MP, Gouveia C, Oliveira MH, et al. Potential role of bile acid receptor FXR in microscopic colitis. Journal of Crohns & Colitis. 2017;11(1):S10.
  • Pinheiro R, Braga C, Santos G, Bronze MR, Perry MJ, Moreira R, et al. Targeting Gliomas: Can a New Alkylating Hybrid Compound Make a Difference? ACS Chemical Neuroscience. 2017;8(1):50–9
  • Pinto S, Cunha C, Barbosa M, Vaz AR, Brites D. Exosomes from NSC-34 cells transfected with hSOD1-G93A are enriched in mir-124 and drive alterations in microglia phenotype. Frontiers in Neuroscience. 2017;11(MAY)
  • Raaf N, Amhis W, Saoula H, Abid A, Nakmouche M, Balamane A, et al. Prevalence, antibiotic resistance, and MLST typing of Helicobacter pylori in Algiers, Algeria. Helicobacter. 2017;22(6)
  • Reis-Pardal J, Rodrigues A, Rodrigues E, Fernandez-Llimos F. Comparing cytochrome P450 pharmacogenetic information available on United States drug labels and European Union Summaries of Product Characteristics. Pharmacogenomics Journal. 2017;17(6):488–93
  • Ribeiro CJA, Nunes RC, Amaral JD, Gonçalves LM, Rodrigues CMP, Moreira R, et al. Spirotriazoline oxindoles: A novel chemical scaffold with in vitro anticancer properties. European Journal of Medicinal Chemistry. 2017;140:494–509
  • Rodrigues C, Antunes F, Gasparovic AC, Soveral G. Role of aquaporins in hydrogen peroxide permeation and oxidative stress. European Biophysics Journal with Biophysics Letters. 2017 Jul;46(1):S269.
  • Rodrigues C, Tartaro Bujak I, Mihaljević B, Soveral G, Cipak Gasparovic A. Yeast aquaporin regulation by 4-hydroxynonenal is implicated in oxidative stress response. IUBMB Life. 2017;69(5):355–62
  • Rodrigues PM, Afonso MB, Simao AL, Carvalho CC, Trindade A, Duarte A, et al. miR-21 ablation and obeticholic acid ameliorate NASH in mice. Journal of Hepatology. 2017;66(1, S):S603.
  • Rodrigues PM, Afonso MB, Simaõ AL, Carvalho CC, Trindade A, Duarte A, et al. MiR-21 ablation and obeticholic acid ameliorate nonalcoholic steatohepatitis in mice. Cell Death and Disease. 2017;8(4)
  • Rosa AI, Fonseca I, Nunes MJ, Moreira S, Rodrigues E, Carvalho AN, et al. Novel insights into the antioxidant role of tauroursodeoxycholic acid in experimental models of Parkinson’s disease. Biochimica et Biophysica Acta - Molecular Basis of Disease. 2017;1863(9):2171–81
  • Sabir F, Loureiro-Dias MC, Soveral G, Prista C. Functional relevance of water and glycerol channels in Saccharomyces cerevisiae. FEMS Microbiology Letters. 2017;364(9).
  • Santos G, Barateiro A, Brites D, Fernandes A. S100B-RAGE signalling affect de novo myelination and remyelination. Glia. 2017 Jun;65(1):E377–8.
  • Santos T, Ferreira R, Quartin E, Boto C, Saraiva C, Bragança J, et al. Blue light potentiates neurogenesis induced by retinoic acid-loaded responsive nanoparticles. Acta Biomaterialia. 2017;59:293–302
  • Secka O, Vale FF, Buissonnière A, Thomas JE, Mégraud F, Lehours P. Phylogeographic agreement between prophage and bacterial housekeeping genes in Helicobacter pylori strains from The Gambia. Helicobacter. 2017;22(5).
  • Silva B, Nunes A, Vale FF, Rocha R, Gomes JP, Dias R, et al. The expression of Helicobacter pylori tfs plasticity zone cluster is regulated by pH and adherence, and its composition is associated with differential gastric IL-8 secretion. Helicobacter. 2017;22(4)
  • Silva RFM, Pogačnik L. Food, polyphenols and neuroprotection. Neural Regeneration Research. 2017;12(4):582–3.
  • Simao AL, Afonso MB, Rodrigues PM, Amaral AJ, Gama-Carvalho M, Cortez-Pinto H, et al. Activation of miR-34a contributes to liver and muscle insulin resistance in experimental and human non-alcoholic fatty liver disease. Journal of Hepatology. 2017;66(1, S):S163.
  • Sousa T, Pokorna S, Bernardes N, Castro RE, Hof M, Banerjee S, et al. Cytoprotective bile acids inhibit Bax activity. European Biophysics Journal with Biophysics Letters. 2017 Jul;46(1):S175.
  • Soveral G, Casini A. Aquaporin modulators: a patent review (2010–2015). Expert Opinion on Therapeutic Patents. 2017;27(1):49–62
  • Tenreiro MM, Correia ML, Brito MA. Endothelial progenitor cells in multiple myeloma neovascularization: a brick to the wall. Angiogenesis. 2017;20(4):443–62
  • Thorell K, Lehours P, Vale FF. Genomics of Helicobacter pylori. Helicobacter. 2017;22
  • Vale FF, Nunes A, Oleastro M, Gomes JP, Sampaio DA, Rocha R, et al. Genomic structure and insertion sites of Helicobacter pylori prophages from various geographical origins. Scientific Reports. 2017;7
  • Vaz AR, Cunha C, Gomes C, Brites D. Reactive astrocytes from the spinal cord of mSOD1 mice pups trigger microglia M1 polarization, while switch mSOD1 microglia into M1/M2 phenotypes that lately become irresponsive. Glia. 2017 Jun;65(1):E153.
  • Vicente JB, Colaço HG, Malagrinò F, Santo PE, Gutierres A, Bandeiras TM, et al. A Clinically Relevant Variant of the Human Hydrogen Sulfide-Synthesizing Enzyme Cystathionine β -Synthase: Increased CO Reactivity as a Novel Molecular Mechanism of Pathogenicity? Oxidative Medicine and Cellular Longevity. 2017;2017
  • Vieira da Silva I, Soveral G. Aquaporins in obesity. Advances in Experimental Medicine and Biology. 2017. 227-238 p.

Menção Honrosa do Prémio APRH 2014/15
Melhor poster analítico no Encontro “Spring Conference: Phytochemicals, health & plant based nutrition, Nutrition Society 2016”
Prémio OIV 2016 na categoria Enologia


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