Ciências Toxicológicas e Bromatológicas

Principais Atividades

Ensino de 1.º, 2.º e 3.º ciclos.
Investigação científica e desenvolvimento tecnológico.
Serviços de extensão universitária:
            serviços ao exterior
            atividades complementares no domínio da formação contínua e da promoção da inovação.


Maria do Rosário Beja de Figueiredo Gonzaga Bronze

Comissão Executiva
Ana Paula Marreilha
Cristina Carvalho
Judite Costa
Lídia Pinheiro
Maria Eduardo Figueira

Comissão de Departamento
A Comissão de Departamento é constituída pelos Doutores do DCTB com vínculo à FFUL


Instituto de Investigação do Medicamento (iMed.ULisboa)
Grupos de Investigação:
            Química Biológica e Toxicológica
            Química de Produtos Naturais
            Ciências Farmacológicas e Regulamentar

Instituto de Biologia Experimental e Tecnológica (iBET)

Centro de Botânica Aplicada à Agricultura (Instituto Superior de Agronomia da ULisboa)




  • Afonso MB, Rodrigues PM, Castro RE, Rodrigues CM. miRNAs as biomarkers and regulators of liver disease. European Journal Of Clinical Investigation. 2017;47(1, SI):19.
  • Afonso MB, Rodrigues PM, Simao AL, Gaspar MM, Castro RE, Rodrigues CMP. miRNA-21-deficiency reduces liver injury, fibrosis and necroptosis in cholestatic bile duct-ligated mice. Journal of Hepatology. 2017;66(1, S):S555.
  • Barateiro A, Mahú I, Domingos AI. Leptin resistance and the neuro-adipose connection. Frontiers in Endocrinology. 2017;8(MAR).
  • Branco V, Coppo L, Solá S, Lu J, Rodrigues CMP, Holmgren A, et al. Impaired cross-talk between the thioredoxin and glutathione systems is related to ASK-1 mediated apoptosis in neuronal cells exposed to mercury. Redox Biology. 2017;13:278–87.
  • Brites D, Monteiro M, Ribeiro AR, Cunha C, Vaz AR, Fernandes A. Role of neuron-microglia secretome and stress-related microRNAS in Alzheimer’s disease. Glia. 2017 Jun;65(1):E301–2.
  • Caldeira C, Cunha C, Vaz AR, Falcão AS, Barateiro A, Seixas E, et al. Key aging-associated alterations in primary microglia response to beta-amyloid stimulation. Frontiers in Aging Neuroscience. 2017;9.
  • Cantante C, Lourenço S, Morais M, Leandro J, Gano L, Silva N, et al. Albumin-binding domain from Streptococcus zooepidemicus protein Zag as a novel strategy to improve the half-life of therapeutic proteins. Journal of Biotechnology. 2017;253:23–33.
  • Carvalho AN, Firuzi O, Gama MJ, van Horssen J, Saso L. Oxidative Stress and Antioxidants in Neurological Diseases: Is There Still Hope? Current Drug Targets. 2017;18(6):705–18.
  • Castro RE, Rodrigues CMP. Cell death and microRNAs in cholestatic liver diseases: Update on potential therapeutic applications. Current Drug Targets. 2017;18(8):921–31.
  • Cavaco MC, Pereira C, Kreutzer B, Gouveia LF, Silva-Lima B, Brito AM, et al. Evading P-glycoprotein mediated-efflux chemoresistance using Solid Lipid Nanoparticles. European Journal of Pharmaceutics and Biopharmaceutics. 2017;110:76–84.
  • Coelho AI, Rubio-Gozalbo ME, Vicente JB, Rivera I. Sweet and sour: an update on classic galactosemia. Journal of Inherited Metabolic Disease. 2017;40(3):325–42.
  • Couto RAS, Goncalves LM, Goes MS, Rodrigues CMP, Beatriz Quinaz M, Rodrigues JA. SAM-Based Immunosensor for the Analysis of Thyroxine (T4). Journal of the Electrochemical Society. 2017;164(4):B103–6.
  • Custódio-Santos T, Videira M, Brito MA. Brain metastasization of breast cancer. Biochimica et Biophysica Acta - Reviews on Cancer. 2017;1868(1):132–47.
  • da Costa M, Bernardi J, Costa L, Fiuza T, Brandão R, Ribeiro MF, et al. N-acetylcysteine treatment attenuates the cognitive impairment and synaptic plasticity loss induced by streptozotocin. Chemico-Biological Interactions. 2017;272:37–46.
  • da Silva I, Rodrigues C, Barroso M, Moura T, Castro R, Soveral G. Biophysical assessment of endothelial aquaporins as water and glycerol channels. European Biophysics Journal with Biophysics Letters. 2017 Jul;46(1):S270.
  • De Almeida A, Mósca AF, Wragg D, Wenzel M, Kavanagh P, Barone G, et al. The mechanism of aquaporin inhibition by gold compounds elucidated by biophysical and computational methods. Chemical Communications. 2017;53(27):3830–3.
  • Direito I, Paulino J, Vigia E, Brito MA, Soveral G. Differential expression of aquaporin-3 and aquaporin-5 in pancreatic ductal adenocarcinoma. Journal of Surgical Oncology. 2017;115(8):980–96.
  • Direito R, Lima A, Rocha J, Ferreira RB, Mota J, Rebelo P, et al. Dyospiros kaki phenolics inhibit colitis and colon cancer cell proliferation, but not gelatinase activities. Journal of Nutritional Biochemistry. 2017;46:100–8.
  • Falcão AS, Carvalho LAR, Lidónio G, Vaz AR, Lucas SD, Moreira R, et al. Dipeptidyl Vinyl Sulfone as a Novel Chemical Tool to Inhibit HMGB1/NLRP3-Inflammasome and Inflamma-miRs in Aβ-Mediated Microglial Inflammation. ACS Chemical Neuroscience. 2017;8(1):89–99.
  • Fernandes A. Targeting in situ neuroinflammation inmultiple sclerosis. IRISH Journal Of Medical Science. 2017 Jul;186(7):S288.
  • Figueira I, Garcia G, Pimpão RC, Terrasso AP, Costa I, Almeida AF, et al. Polyphenols journey through blood-brain barrier towards neuronal protection. Scientific Reports. 2017;7(1).
  • Figueira I, Tavares L, Jardim C, Costa I, Terrasso AP, Almeida AF, et al. Blood-brain barrier transport and neuroprotective potential of blackberry-digested polyphenols: an in vitro study. European Journal of Nutrition. 2017;1–18.
  • Fonseca I, Gordino G, Moreira S, Nunes MJ, Azevedo C, Gama MJ, et al. Erratum to: Tauroursodeoxycholic Acid Protects Against Mitochondrial Dysfunction and Cell Death via Mitophagy in Human Neuroblastoma Cells (Molecular Neurobiology, (2017), 54, 8, (6107-6119), 10.1007/s12035-016-0145-3). Molecular Neurobiology. 2017;54(8):6120.
  • Fonseca I, Gordino G, Moreira S, Nunes MJ, Azevedo C, Gama MJ, et al. Tauroursodeoxycholic Acid Protects Against Mitochondrial Dysfunction and Cell Death via Mitophagy in Human Neuroblastoma Cells. Molecular Neurobiology. 2017;54(8):6107–19.
  • Freitas MA, Brites D, Bota A. Desensitization study of paclitaxel and carboplatin drug in the ovary tumor protocol in Cuf Descobertas Hospital. International Journal of Clinical Pharmacy. 2017;39(1):259.
  • Gama-Marques J, Tinoco I, Pedro I, Leote F, Ouakinin RSS. Unconjugated bilirubin and acute schizophrenia: A probable correlation? [Bilirrubina no conjugada y esquizofrenia aguda: ¿una correlación probable?] Actas Espanolas de Psiquiatria. 2017;45(2):79.
  • Garcia G, Nanni S, Figueira I, Ivanov I, McDougall GJ, Stewart D, et al. Bioaccessible (poly)phenol metabolites from raspberry protect neural cells from oxidative stress and attenuate microglia activation. Food Chemistry. 2017;215:274–83.
  • Leandro J, Saraste J, Leandro P, Flatmark T. PKU mutation p.G46S prevents the stereospecific binding of L-phenylalanine to the dimer of human phenylalanine hydroxylase regulatory domain. FEBS Open Bio. 2017;7(2):195–203.
  • Leandro J, Stokka AJ, Teigen K, Andersen OA, Flatmark T. Substituting Tyr(138) in the active site loop of human phenylalanine hydroxylase affects catalysis and substrate activation. FEBS Open Bio. 2017 Jul;7(7):1026–36.
  • Lopes PA, Martins AP, Martins SV, Madeira MS, Santos NC, Moura TF, et al. Higher membrane fluidity mediates the increased subcutaneous fatty acid content in pigs fed reduced protein diets. Animal. 2017;11(4):713–9
  • Marques F, Sousa JC, Brito MA, Pahnke J, Santos C, Correia-Neves M, et al. The choroid plexus in health and in disease: dialogues into and out of the brain. Neurobiology of Disease. 2017;107:32–40
  • Martins SV, Pires VMR, Madeira AP, Nascimento M, Alfaia CM, Castro MF, et al. Novel anti-adipogenic properties of the individual trans8,cis10 conjugated linoleic acid (CLA) isomer in 3T3-L1 adipocytes. European Journal of Lipid Science and Technology. 2017;119(2)
  • Moedas MF, Adam AAA, Farelo MA, IJlst L, Chamuleau RAFM, Hoekstra R, et al. Advances in methods for characterization of hepatic urea cycle enzymatic activity in HepaRG cells using UPLC-MS/MS. Analytical Biochemistry. 2017;535:47–55
  • Moreira S, Fonseca I, Nunes MJ, Rosa A, Lemos L, Rodrigues E, et al. Nrf2 activation by tauroursodeoxycholic acid in experimental models of Parkinson’s disease. Experimental Neurology. 2017;295:77–87
  • Morris AAM, Kozich V, Santra S, Andria G, Ben-Omran TIM, Chakrapani AB, et al. Guidelines for the diagnosis and management of cystathionine beta-synthase deficiency. Journal of Inherited Metabolic Disease. 2017 Jan;40(1):49–74
  • Mosca AF, de Almeida A, Rodrigues C, Casini A, Soveral G. Roles of Aquaporins in health and disease: promising targets for drug discovery. European Biophysics Journal with Biophysics Letters. 2017 Jul;46(1):S77.
  • Mosca AF, Rodrigues C, Martins AP, Prista C, Soveral G. Rat aquaporin-5 is pH-gated induced by phosphorylation. European Biophysics Journal with Biophysics Letters. 2017 Jul;46(1):S288.
  • Moutinho M, Nunes MJ, Rodrigues E. The mevalonate pathway in neurons: It’s not just about cholesterol. Experimental Cell Research. 2017;360(1):55–60
  • Méndez-Giménez L, Becerril S, Camões SP, Da Silva IV, Rodrigues C, Moncada R, et al. Role of aquaporin-7 in ghrelin-and GLP-1-induced improvement of pancreatic β-cell function after sleeve gastrectomy in obese rats. International Journal of Obesity. 2017;41(9):1394–402
  • Méndez-Giménez L, Becerril S, Moncada R, Valentí V, Fernández S, Ramírez B, et al. Gastric Plication Improves Glycemia Partly by Restoring the Altered Expression of Aquaglyceroporins in Adipose Tissue and the Liver in Obese Rats. Obesity Surgery. 2017;27(7):1763–74
  • Nunes A, Ramalho R, Rodrigues CMP. Morte celular no sistema nervoso. In: Rego AC, Duarte CB, Oliveira CR, editors. Neurociências. Lisboa: Lidel; 2017. p. 499–512.
  • Nunes RC, Ribeiro CJA, Monteiro Â, Rodrigues CMP, Amaral JD, Santos MMM. In vitro targeting of colon cancer cells using spiropyrazoline oxindoles. European Journal of Medicinal Chemistry. 2017;139:168–79
  • Oleastro M, Rocha R, Vale FF. Ancestry and spread of Portuguese Helicobacter pylori strains. Helicobacter. 2017;22(1, SI).
  • Oleastro M, Rocha R, Vale FF. Population genetic structure of Helicobacter pylori strains from Portuguese-speaking countries. Helicobacter. 2017;22(4)
  • Palmela C, Torres J, de Sena PG, Costa Santos MP, Gouveia C, Oliveira MH, et al. Potential role of bile acid receptor FXR in microscopic colitis. Journal of Crohns & Colitis. 2017;11(1):S10.
  • Pinheiro R, Braga C, Santos G, Bronze MR, Perry MJ, Moreira R, et al. Targeting Gliomas: Can a New Alkylating Hybrid Compound Make a Difference? ACS Chemical Neuroscience. 2017;8(1):50–9
  • Pinto S, Cunha C, Barbosa M, Vaz AR, Brites D. Exosomes from NSC-34 cells transfected with hSOD1-G93A are enriched in mir-124 and drive alterations in microglia phenotype. Frontiers in Neuroscience. 2017;11(MAY)
  • Raaf N, Amhis W, Saoula H, Abid A, Nakmouche M, Balamane A, et al. Prevalence, antibiotic resistance, and MLST typing of Helicobacter pylori in Algiers, Algeria. Helicobacter. 2017;22(6)
  • Reis-Pardal J, Rodrigues A, Rodrigues E, Fernandez-Llimos F. Comparing cytochrome P450 pharmacogenetic information available on United States drug labels and European Union Summaries of Product Characteristics. Pharmacogenomics Journal. 2017;17(6):488–93
  • Ribeiro CJA, Nunes RC, Amaral JD, Gonçalves LM, Rodrigues CMP, Moreira R, et al. Spirotriazoline oxindoles: A novel chemical scaffold with in vitro anticancer properties. European Journal of Medicinal Chemistry. 2017;140:494–509
  • Rodrigues C, Antunes F, Gasparovic AC, Soveral G. Role of aquaporins in hydrogen peroxide permeation and oxidative stress. European Biophysics Journal with Biophysics Letters. 2017 Jul;46(1):S269.
  • Rodrigues C, Tartaro Bujak I, Mihaljević B, Soveral G, Cipak Gasparovic A. Yeast aquaporin regulation by 4-hydroxynonenal is implicated in oxidative stress response. IUBMB Life. 2017;69(5):355–62
  • Rodrigues PM, Afonso MB, Simao AL, Carvalho CC, Trindade A, Duarte A, et al. miR-21 ablation and obeticholic acid ameliorate NASH in mice. Journal of Hepatology. 2017;66(1, S):S603.
  • Rodrigues PM, Afonso MB, Simaõ AL, Carvalho CC, Trindade A, Duarte A, et al. MiR-21 ablation and obeticholic acid ameliorate nonalcoholic steatohepatitis in mice. Cell Death and Disease. 2017;8(4)
  • Rosa AI, Fonseca I, Nunes MJ, Moreira S, Rodrigues E, Carvalho AN, et al. Novel insights into the antioxidant role of tauroursodeoxycholic acid in experimental models of Parkinson’s disease. Biochimica et Biophysica Acta - Molecular Basis of Disease. 2017;1863(9):2171–81
  • Sabir F, Loureiro-Dias MC, Soveral G, Prista C. Functional relevance of water and glycerol channels in Saccharomyces cerevisiae. FEMS Microbiology Letters. 2017;364(9).
  • Santos G, Barateiro A, Brites D, Fernandes A. S100B-RAGE signalling affect de novo myelination and remyelination. Glia. 2017 Jun;65(1):E377–8.
  • Santos T, Ferreira R, Quartin E, Boto C, Saraiva C, Bragança J, et al. Blue light potentiates neurogenesis induced by retinoic acid-loaded responsive nanoparticles. Acta Biomaterialia. 2017;59:293–302
  • Secka O, Vale FF, Buissonnière A, Thomas JE, Mégraud F, Lehours P. Phylogeographic agreement between prophage and bacterial housekeeping genes in Helicobacter pylori strains from The Gambia. Helicobacter. 2017;22(5).
  • Silva B, Nunes A, Vale FF, Rocha R, Gomes JP, Dias R, et al. The expression of Helicobacter pylori tfs plasticity zone cluster is regulated by pH and adherence, and its composition is associated with differential gastric IL-8 secretion. Helicobacter. 2017;22(4)
  • Silva RFM, Pogačnik L. Food, polyphenols and neuroprotection. Neural Regeneration Research. 2017;12(4):582–3.
  • Simao AL, Afonso MB, Rodrigues PM, Amaral AJ, Gama-Carvalho M, Cortez-Pinto H, et al. Activation of miR-34a contributes to liver and muscle insulin resistance in experimental and human non-alcoholic fatty liver disease. Journal of Hepatology. 2017;66(1, S):S163.
  • Sousa T, Pokorna S, Bernardes N, Castro RE, Hof M, Banerjee S, et al. Cytoprotective bile acids inhibit Bax activity. European Biophysics Journal with Biophysics Letters. 2017 Jul;46(1):S175.
  • Soveral G, Casini A. Aquaporin modulators: a patent review (2010–2015). Expert Opinion on Therapeutic Patents. 2017;27(1):49–62
  • Tenreiro MM, Correia ML, Brito MA. Endothelial progenitor cells in multiple myeloma neovascularization: a brick to the wall. Angiogenesis. 2017;20(4):443–62
  • Thorell K, Lehours P, Vale FF. Genomics of Helicobacter pylori. Helicobacter. 2017;22
  • Vale FF, Nunes A, Oleastro M, Gomes JP, Sampaio DA, Rocha R, et al. Genomic structure and insertion sites of Helicobacter pylori prophages from various geographical origins. Scientific Reports. 2017;7
  • Vaz AR, Cunha C, Gomes C, Brites D. Reactive astrocytes from the spinal cord of mSOD1 mice pups trigger microglia M1 polarization, while switch mSOD1 microglia into M1/M2 phenotypes that lately become irresponsive. Glia. 2017 Jun;65(1):E153.
  • Vicente JB, Colaço HG, Malagrinò F, Santo PE, Gutierres A, Bandeiras TM, et al. A Clinically Relevant Variant of the Human Hydrogen Sulfide-Synthesizing Enzyme Cystathionine β -Synthase: Increased CO Reactivity as a Novel Molecular Mechanism of Pathogenicity? Oxidative Medicine and Cellular Longevity. 2017;2017
  • Vieira da Silva I, Soveral G. Aquaporins in obesity. Advances in Experimental Medicine and Biology. 2017. 227-238 p.


  • Afonso MB, Rodrigues PM, Simao AL, Castro RE. Circulating microRNAs as Potential Biomarkers in Non-Alcoholic Fatty Liver Disease and Hepatocellular Carcinoma. Journal o Clinical Medicine. 2016 Mar;5(3).
  • Afonso MB, Rodrigues PM, Simao AL, Cortez-Pinto H, Ofengeim D, Amaral JD, et al. RIP3 Regulates Acute Cholestasis-Associated Necroptotic Signaling and Cell Death. Journal of Hepatology. 2016;64(2):S349.
  • Afonso MB, Rodrigues PM, Simão AL, Ofengeim D, Carvalho T, Amaral JD, et al. Activation of necroptosis in human and experimental cholestasis. Cell Death and Disease. 2016;7(9).
  • Almeida A, Martins AP, Mosca AF, Wijma HJ, Prista C, Soveral G, et al. Exploring the gating mechanisms of aquaporin-3: new clues for the design of inhibitors? Molecular Biosystems. 2016;12(5):1564–73.
  • Barateiro A, Afonso V, Santos G, Cerqueira JJ, Brites D, van Horssen J, et al. S100B as a Potential Biomarker and Therapeutic Target in Multiple Sclerosis. Molecular Neurobiology. 2016;53(6):3976–91.
  • Barateiro A, Brites D, Fernandes A. Oligodendrocyte development and myelination in neurodevelopment: Molecular mechanisms in health and disease. Current Pharmaceutical Design. 2016;22(6):656–79.
  • Barateiro A, Chen S, Yueh M-F, Fernandes A, Domingues HS, Relvas J, et al. Reduced myelination and increased glia reactivity resulting from severe neonatal hyperbilirubinemia. Molecular Pharmacology. 2016;89(1):84–93.
  • Barateiro A, Mahu I, Domingos AI. Leptin Resistance and the Neuro-Adipose Connection. Frontiers In Endocrinology. 2016 Mar;8.
  • Barroso M, Kao D, Blom HJ, Tavares de Almeida I, Castro R, Loscalzo J, et al. S-adenosylhomocysteine induces inflammation through NFkB: A possible role for EZH2 in endothelial cell activation. Biochimica et Biophysica Acta - Molecular Basis of Disease. 2016;1862(1):82–92.
  • Bonito CA, Leandro P, Ventura FV, Guedes RC. Insights into Medium-chain Acyl-CoA Dehydrogenase Structure by Molecular Dynamics Simulations. Chemical Biology and Drug Design. 2016;88(2):281–92.
  • Bonito CA, Nunes J, Leandro J, Louro F, Leandro P, Ventura FV, et al. Unveiling the Pathogenic Molecular Mechanisms of the Most Common Variant (p.K329E) in Medium-Chain Acyl-CoA Dehydrogenase Deficiency by in Vitro and in Silico Approaches. Biochemistry. 2016;55(51):7086–98.
  • Carvalho AN, Firuzi O, Gama MJ, van Horssen J, Saso L. Oxidative stress and antioxidants in neurological diseases: Is there still hope? Current Drug Targets. 2016;17(16).
  • Carvalho AN, Marques C, Guedes RC, Castro-Caldas M, Rodrigues E, Van Horssen J, et al. S-Glutathionylation of Keap1: A new role for glutathione S-transferase pi in neuronal protection. FEBS Letters. 2016;590(10):1455–66.
  • Cunha C, Gomes C, Vaz AR, Brites D. Exploring New Inflammatory Biomarkers and Pathways during LPS-Induced M1 Polarization. Mediators of Inflammation. 2016;2016.
  • Direito I, Madeira A, Brito MA, Soveral G. Aquaporin-5: From structure to function and dysfunction in cancer. Cellular and Molecular Life Sciences. 2016;73(8):1623–40.
  • Drechsler S, Lynch MA, Novella S, González-Navarro H, Hecimovic S, Barini E, et al. With mouse age comes wisdom: A review and suggestions of relevant mouse models for age-related conditions. Mechanisms of Ageing and Development. 2016;160:54–68.
  • Duran M, Tavares de Almeida I. Interpretation of acylcarnitines analysis results. In: Inherited Metabolic Disease in Adults: A Clinical Guide, Part C. Oxford: Oxford University Press; 2016. p. 569–72.
  • Duran M, Tavares de Almeida I. Interpretation of organic acid analysis results. In: Interpretation of organic acid analysis results. Oxford: Oxford University Press; 2016. p. 565–8.
  • Estudante M, Soveral G, Morais JG, Benet LZ. Insights into solute carriers: physiological functions and implications in disease and pharmacokinetics. MedChemComm. 2016;7(8):1462–78.
  • Figueira I, Fernandes A, Djordjevic AM, Lopez-Contreras A, Henriques CM, Selman C, et al. Interventions for age-related diseases: Shifting the paradigm. Mechanisms of Ageing and Development. 2016;160:69–92.
  • Figueira M-E, Oliveira M, Direito R, Rocha J, Alves P, Serra A-T, et al. Protective effects of a blueberry extract in acute inflammation and collagen-induced arthritis in the rat. Biomedicine and Pharmacotherapy. 2016;83:1191–202.
  • Florindo PR, Pereira DM, Borralho PM, Costa PJ, Piedade MFM, Rodrigues CMP, et al. New [(η5-C5H5)Ru(N-N)(PPh3)][PF6]compounds: Colon anticancer activity and GLUT-mediated cellular uptake of carbohydrate-appended complexes. Dalton Transactions. 2016;45(30):11926–30.
  • Gomes SE, Simões AES, Pereira DM, Castro RE, Rodrigues CMP, Borralho PM. miR-143 or miR-145 overexpression increases cetuximab-mediated antibody-dependent cellular cytotoxicity in human colon cancer cells. Oncotarget. 2016;7(8):9368–87.
  • Gronbeck KR, Rodrigues CMP, Mahmoudi J, Bershad EM, Ling G, Bachour SP, et al. Application of Tauroursodeoxycholic Acid for Treatment of Neurological and Non-neurological Diseases: Is There a Potential for Treating Traumatic Brain Injury? Neurocritical Care. 2016;25(1):153–66.
  • Houten SM, Violante S, Ventura FV, Wanders RJA. The Biochemistry and Physiology of Mitochondrial Fatty Acid β-Oxidation and Its Genetic Disorders. Annual Review of Physiology. 2016;78:23-44.
  • Janota C, Lemere CA, Brito MA. Dissecting the Contribution of Vascular Alterations and Aging to Alzheimer’s Disease. Molecular Neurobiology. 2016;53(6):3793–811.
  • Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Arozena AA, et al. Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356. Autophagy. 2016;12(2):443.
  • Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Arozena AA, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016;12(1):1–222.
  • Madeira A, Moura T, Soveral G. Aquaporin functional detection: basics concepts on water and solute permeation. In: Aquaporins in Health and Disease: New Molecular Targets for Drug Discovery. Boca Raton: CRC Press (Taylor & Francis); 2016. p. 3–17.
  • Madeira A, Moura TF, Soveral G. Detecting aquaporin function and regulation. Frontiers in Chemistry. 2016;4(FEB).
  • Magalhaes A, Matias I, Palmela I, Brito MA, Dias S. LDL-cholesterol increases the transcytosis of molecules through endothelial monolayers. PLoS ONE. 2016;11(10).
  • Marques C, Santos-Silva C, Rodrigues C, Matos J, Moura T, Baptista MC, et al. Effect of different cocktails of cryoprotectants and calcium on bovine oocyte membrane permeability and cryosurvival. Reproduction In Domestic Animals. 2016;51(2, SI):114.
  • Mendez-Gimenez L, Becerril S, Moncada R, Valenti V, Cienfuegos JA, Ramirez B, et al. Gastric plication reduces glycemia, through the improvement of the altered expression of aquaglyceroporins in adipose tissue and liver in diet-induced obese rats. European Journal of Clinical Investigation. 2016;46(1, SI):28.
  • Moedas MF, van Cruchten AG, IJlst L, Kulik W, de Almeida IT, Diogo L, et al. Transient decrease of hepatic NAD+and amino acid alterations during treatment with valproate: new insights on drug-induced effects in vivo using targeted MS-based metabolomics. Metabolomics. 2016;12(8).
  • Morgado AL, Rodrigues CMP, Solá S. MicroRNA-145 Regulates Neural Stem Cell Differentiation Through the Sox2-Lin28/let-7 Signaling Pathway. Stem Cells. 2016;34(5):1386–95.
  • Moutinho M, Nunes MJ, Correia JC, Gama MJ, Castro-Caldas M, Cedazo-Minguez A, et al. Neuronal cholesterol metabolism increases dendritic outgrowth and synaptic markers via a concerted action of GGTase-I and Trk. Scientific Reports. 2016;6.
  • Moutinho M, Nunes MJ, Rodrigues E. Cholesterol 24-hydroxylase: Brain cholesterol metabolism and beyond. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 2016;1861(12):1911–20.
  • Mégraud F, Lehours P, Vale FF. The history of Helicobacter pylori: from phylogeography to paleomicrobiology. Clinical Microbiology and Infection. 2016;22(11):922–7.
  • Nave M, Castro RE, Rodrigues CMP, Casini A, Soveral G, Gaspar MM. Nanoformulations of a potent copper-based aquaporin inhibitor with cytotoxic effect against cancer cells. Nanomedicine. 2016;11(14):1817–30.
  • Noronha H, Araujo D, Conde C, Martins AP, Soveral G, Chaumont F, et al. The Grapevine Uncharacterized Intrinsic Protein 1 (VvXIP1) Is Regulated by Drought Stress and Transports Glycerol, Hydrogen Peroxide, Heavy Metals but Not Water. PLOS One. 2016;11(8).
  • Oleastro M, Rocha R, Vale FF. Population structure of Helicobacter Pylori isolates from Portuguese speaking countries. Helicobacter. 2016;21(1, SI):126.
  • Palmela I, Correia L, Silva R, Sasaki H, Kim K, Brites D, et al. Hydrophilic bile acids protect human blood-brain barrier endothelial cells from disruption by unconjugated bilirubin: an in vitro study. In: Ontogeny and phylogeny of brain barrier mechanisms. Lausanne: Frontiers Media SA; 2016. p. 335–45.
  • Paterna A, Gomes SE, Borralho PM, Mulhovo S, Rodrigues CMP, Ferreira M-JU. (3′R)-hydroxytabernaelegantine C: A bisindole alkaloid with potent apoptosis inducing activity in colon (HCT116, SW620) and liver (HepG2) cancer cells. Journal of Ethnopharmacology. 2016;194:236–44.
  • Paterna A, Gomes SE, Borralho PM, Mulhovo S, Rodrigues CMP, Ferreira M-JU. Vobasinyl-Iboga Alkaloids from Tabernaemontana elegans: Cell Cycle Arrest and Apoptosis-Inducing Activity in HCT116 Colon Cancer Cells. Journal of Natural Products. 2016;79(10):2624–34.
  • Pereira DM, Simões AES, Gomes SE, Castro RE, Carvalho T, Rodrigues CMP, et al. MEK5/ERK5 signaling inhibition increases colon cancer cell sensitivity to 5-fluorouracil through a p53-dependent mechanism. Oncotarget. 2016;7(23):34322–40.
  • Pereira R, Mesquita P, Matos J, Baptista M, Silva E, Horta A, et al. Effect of P2Y2 receptors modulation on bovine oocyte cryosurvival. Reproduction in Domestic Animals. 2016;51(2, SI):129.
  • Pinheiro A, Silva MJ, Pavlu-Pereira H, Florindo C, Barroso M, Marques B, et al. Complex genetic findings in a female patient with pyruvate dehydrogenase complex deficiency: Null mutations in the PDHX gene associated with unusual expression of the testis-specific PDHA2 gene in her somatic cells. Gene. 2016;591(2):417–24.
  • Pogačnik L, Pirc K, Palmela I, Skrt M, Kwang KS, Brites D, et al. Potential for brain accessibility and analysis of stability of selected flavonoids in relation to neuroprotection in vitro. Brain Research. 2016;1651:17–26.
  • Prieto-Davó A, Dias T, Gomes SE, Rodrigues S, Parera-Valadez Y, Borralho PM, et al. The madeira archipelago as a significant source of marine-derived actinomycete diversity with anticancer and antimicrobial potential. Frontiers in Microbiology. 2016;7(OCT).
  • Ribeiro CJA, Amaral JD, Rodrigues CMP, Moreira R, Santos MMM. Spirooxadiazoline oxindoles with promising in vitro antitumor activities. MedChemComm. 2016;7(3):420–5.
  • Ribeiro CJA, Rodrigues CMP, Moreira R, Santos MMM. Chemical variations on the p53 reactivation theme. Pharmaceuticals. 2016;9(2).
  • Ribeiro FF, Neves-Tomé R, Assaife-Lopes N, Santos TE, Silva RFM, Brites D, et al. Axonal elongation and dendritic branching is enhanced by adenosine A2Areceptors activation in cerebral cortical neurons. Brain Structure and Function. 2016;221(5):2777–99.
  • Rodrigues C, Mósca AF, Martins AP, Nobre T, Prista C, Antunes F, et al. Rat aquaporin-5 is pH-gated induced by phosphorylation and is implicated in oxidative stress. International Journal of Molecular Sciences. 2016;17(12).
  • Rodrigues CMP, Moshage H. Targeting TGR5 in cholangiocyte proliferation: Default topic. Gut. 2016;65(3):369–70.
  • Rodrigues PM, Afonso MB, Simao AL, Caridade M, Carvalho CC, Trindade A, et al. MIR-21 Inhibition and Obeticholic Acid Ameliorate Non-Alcoholic Steatohepatitis In Dietary Animal Models. Journal of Hepatology. 2016;64(2):S681–2.
  • Rodriguez A, Moreno NR, Balaguer I, Mendez-Gimenez L, Becerril S, Catalan V, et al. Leptin replacement improves the non-alcoholic fatty liver of ob/ob mice partly through the restoration of the altered adipose and hepatic expression of aquaglyceroporins. European Journal of Clinical Investigation. 2016;46(1, SI):29.
  • Sabir F, Loureiro-Dias MC, Prista C. Comparative analysis of sequences, polymorphisms and topology of yeasts aquaporins and aquaglyceroporins. FEMS Yeast Research. 2016;16(3).
  • Sabir F, Prista C, Madeira A, Moura T, Loureiro-Dias M, Soveral G. Water transport in yeasts. In: Yeast Membrane Transport, Advances in Experimental Medicine and Biology, vol 892. Cham, Basel: Springer; 2016. p. 107–24.
  • Simões AES, Rodrigues CMP, Borralho PM. The MEK5/ERK5 signalling pathway in cancer: a promising novel therapeutic target. Drug Discovery Today. 2016;21(10):1654–63.
  • Soveral G, Nielsen S, Casini A.(Eds). Aquaporins in Health and Disease: New Molecular Targets for Drug Discovery. Boca Raton ; London ; New York : CRC Press, Taylor & Francis Group, 2016
  • Tenreiro MM, Ferreira R, Bernardino L, Brito MA. Cellular response of the blood-brain barrier to injury: Potential biomarkers and therapeutic targets for brain regeneration. Neurobiology of Disease. 2016 Jul;91:262–73.
  • Tenreiro MM, Malho R, Silveira M, Correia ML, Brito MA. A novel tool to monitor angiogenesis in bone marrow smears: detection and quantification of endothelial progenitor cells by multiple-labeling immunofluorescence analysis. Haematologica. 2016 Jun;101(1):782–3.
  • Vale F, Vítor J, Oleastro M. Probiotics as an alternative therapy for Helicobacter pylori-associated diseases. In: Helicobacter pylori Research: From Bench to Bedside. Cham, Basel: Springer; 2016. p. 543–74.
  • Vale FF, Nunes A, Oleastro M, Gomes JP, Sampaio DA, Rocha R, et al. Genomes of Helicobacter pylori prophages. Helicobacter. 2016;21(1, SI):86.
  • Vale FF, Vítor JMB, Oleastro M. Probiotics as an alternative therapy for Helicobacter pylori-associated diseases. Helicobacter pylori Research: From Bench to Bedside. 2016. 543-574 p.
  • Vaz A, Gomes C, Cunha C, Brites D. Astrocytes in Amyotrophic Lateral Sclerosis: Harmful Effects and Strategies to Afford Neuroprotection. In: New Developments in Astrocytes Research. New York: Nova Science Publishers; 2016. p. 67–111.
  • Vicente JB, Colaço HG, Sarti P, Leandro P, Giuffrè A. S-adenosyl-L-methionine modulates CO and NO· binding to the human H2S-generating enzyme cystathionine β-synthase. Journal of Biological Chemistry. 2016;291(2):572–81.
  • von Zglinicki T, Varela Nieto I, Brites D, Karagianni N, Ortolano S, Georgopoulos S, et al. Frailty in mouse ageing: A conceptual approach. Mechanisms of Ageing and Development. 2016;160:34–40.
  • Xavier JM, Rodrigues CMP, Solá S. Mitochondria: Major Regulators of Neural Development. Neuroscientist. 2016;22(4):346–58.
  • Zarrouk O, Garcia-Tejero I, Pinto C, Genebra T, Sabir F, Prista C, et al. Aquaporins isoforms in cv. Touriga Nacional grapevine under water stress and recovery-Regulation of expression in leaves and roots. Agricultural Water Management. 2016 Jan;164(1, SI):167–75.

Menção Honrosa do Prémio APRH 2014/15
Melhor poster analítico no Encontro “Spring Conference: Phytochemicals, health & plant based nutrition, Nutrition Society 2016”
Prémio OIV 2016 na categoria Enologia


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