Ciências Toxicológicas e Bromatológicas

Principais Atividades

Ensino de 1.º, 2.º e 3.º ciclos.
Investigação científica e desenvolvimento tecnológico.
Serviços de extensão universitária:
            serviços ao exterior
            atividades complementares no domínio da formação contínua e da promoção da inovação.

Órgãos

Presidente
Maria do Rosário Beja de Figueiredo Gonzaga Bronze

Comissão Executiva
Ana Paula Marreilha
Cristina Carvalho
Judite Costa
Lídia Pinheiro
Maria Eduardo Figueira

Comissão de Departamento
A Comissão de Departamento é constituída pelos Doutores do DCTB com vínculo à FFUL

Investigação

Instituto de Investigação do Medicamento (iMed.ULisboa)
           
Grupos de Investigação:
            Química Biológica e Toxicológica
            Química de Produtos Naturais
            Ciências Farmacológicas e Regulamentar

Instituto de Biologia Experimental e Tecnológica (iBET)

Centro de Botânica Aplicada à Agricultura (Instituto Superior de Agronomia da ULisboa)

2017

ReferênciaTipo de Documento
Nunes A, Ramalho R, Rodrigues CMP. Morte celular no sistema nervoso. In: Rego AC, Duarte CB, Oliveira CR, editors. Neurociências. Lisboa: Lidel; 2017. p. 499–512.

Livros e Capítulos de Livros

Vicente JB, Colaço HG, Malagrinò F, Santo PE, Gutierres A, Bandeiras TM, et al. A Clinically Relevant Variant of the Human Hydrogen Sulfide-Synthesizing Enzyme Cystathionine β -Synthase: Increased CO Reactivity as a Novel Molecular Mechanism of Pathogenicity? Oxidative Medicine and Cellular Longevity. 2017;2017

Artigos

Vale FF, Nunes A, Oleastro M, Gomes JP, Sampaio DA, Rocha R, et al. Genomic structure and insertion sites of Helicobacter pylori prophages from various geographical origins. Scientific Reports. 2017;7

Artigos

Thorell K, Lehours P, Vale FF. Genomics of Helicobacter pylori. Helicobacter. 2017;22

Artigos

Tenreiro MM, Correia ML, Brito MA. Endothelial progenitor cells in multiple myeloma neovascularization: a brick to the wall. Angiogenesis. 2017;20(4):443–62

Artigos

Soveral G, Casini A. Aquaporin modulators: a patent review (2010–2015). Expert Opinion on Therapeutic Patents. 2017;27(1):49–62

Artigos

Silva B, Nunes A, Vale FF, Rocha R, Gomes JP, Dias R, et al. The expression of Helicobacter pylori tfs plasticity zone cluster is regulated by pH and adherence, and its composition is associated with differential gastric IL-8 secretion. Helicobacter. 2017;22(4)

Artigos

Santos T, Ferreira R, Quartin E, Boto C, Saraiva C, Bragança J, et al. Blue light potentiates neurogenesis induced by retinoic acid-loaded responsive nanoparticles. Acta Biomaterialia. 2017;59:293–302

Artigos

Rosa AI, Fonseca I, Nunes MJ, Moreira S, Rodrigues E, Carvalho AN, et al. Novel insights into the antioxidant role of tauroursodeoxycholic acid in experimental models of Parkinson’s disease. Biochimica et Biophysica Acta - Molecular Basis of Disease. 2017;1863(9):2171–81

Artigos

Rodrigues PM, Afonso MB, Simaõ AL, Carvalho CC, Trindade A, Duarte A, et al. MiR-21 ablation and obeticholic acid ameliorate nonalcoholic steatohepatitis in mice. Cell Death and Disease. 2017;8(4)

Artigos

Rodrigues C, Tartaro Bujak I, Mihaljević B, Soveral G, Cipak Gasparovic A. Yeast aquaporin regulation by 4-hydroxynonenal is implicated in oxidative stress response. IUBMB Life. 2017;69(5):355–62

Artigos

Ribeiro CJA, Nunes RC, Amaral JD, Gonçalves LM, Rodrigues CMP, Moreira R, et al. Spirotriazoline oxindoles: A novel chemical scaffold with in vitro anticancer properties. European Journal of Medicinal Chemistry. 2017;140:494–509

Artigos

Reis-Pardal J, Rodrigues A, Rodrigues E, Fernandez-Llimos F. Comparing cytochrome P450 pharmacogenetic information available on United States drug labels and European Union Summaries of Product Characteristics. Pharmacogenomics Journal. 2017;17(6):488–93

Artigos

Raaf N, Amhis W, Saoula H, Abid A, Nakmouche M, Balamane A, et al. Prevalence, antibiotic resistance, and MLST typing of Helicobacter pylori in Algiers, Algeria. Helicobacter. 2017;22(6)

Artigos

Pinto S, Cunha C, Barbosa M, Vaz AR, Brites D. Exosomes from NSC-34 cells transfected with hSOD1-G93A are enriched in mir-124 and drive alterations in microglia phenotype. Frontiers in Neuroscience. 2017;11(MAY)

Artigos

Pinheiro R, Braga C, Santos G, Bronze MR, Perry MJ, Moreira R, et al. Targeting Gliomas: Can a New Alkylating Hybrid Compound Make a Difference? ACS Chemical Neuroscience. 2017;8(1):50–9

Artigos

Oleastro M, Rocha R, Vale FF. Population genetic structure of Helicobacter pylori strains from Portuguese-speaking countries. Helicobacter. 2017;22(4)

Artigos

Nunes RC, Ribeiro CJA, Monteiro Â, Rodrigues CMP, Amaral JD, Santos MMM. In vitro targeting of colon cancer cells using spiropyrazoline oxindoles. European Journal of Medicinal Chemistry. 2017;139:168–79

Artigos

Moutinho M, Nunes MJ, Rodrigues E. The mevalonate pathway in neurons: It’s not just about cholesterol. Experimental Cell Research. 2017;360(1):55–60

Artigos

Morris AAM, Kozich V, Santra S, Andria G, Ben-Omran TIM, Chakrapani AB, et al. Guidelines for the diagnosis and management of cystathionine beta-synthase deficiency. Journal of Inherited Metabolic Disease. 2017 Jan;40(1):49–74

Artigos

Moreira S, Fonseca I, Nunes MJ, Rosa A, Lemos L, Rodrigues E, et al. Nrf2 activation by tauroursodeoxycholic acid in experimental models of Parkinson’s disease. Experimental Neurology. 2017;295:77–87

Artigos

Moedas MF, Adam AAA, Farelo MA, IJlst L, Chamuleau RAFM, Hoekstra R, et al. Advances in methods for characterization of hepatic urea cycle enzymatic activity in HepaRG cells using UPLC-MS/MS. Analytical Biochemistry. 2017;535:47–55

Artigos

Méndez-Giménez L, Becerril S, Moncada R, Valentí V, Fernández S, Ramírez B, et al. Gastric Plication Improves Glycemia Partly by Restoring the Altered Expression of Aquaglyceroporins in Adipose Tissue and the Liver in Obese Rats. Obesity Surgery. 2017;27(7):1763–74

Artigos

Méndez-Giménez L, Becerril S, Camões SP, Da Silva IV, Rodrigues C, Moncada R, et al. Role of aquaporin-7 in ghrelin-and GLP-1-induced improvement of pancreatic β-cell function after sleeve gastrectomy in obese rats. International Journal of Obesity. 2017;41(9):1394–402

Artigos

Martins SV, Pires VMR, Madeira AP, Nascimento M, Alfaia CM, Castro MF, et al. Novel anti-adipogenic properties of the individual trans8,cis10 conjugated linoleic acid (CLA) isomer in 3T3-L1 adipocytes. European Journal of Lipid Science and Technology. 2017;119(2)

Artigos

2016

ReferênciaTipo de Documento
Vicente JB, Colaço HG, Sarti P, Leandro P, Giuffrè A. S-adenosyl-L-methionine modulates CO and NO· binding to the human H2S-generating enzyme cystathionine β-synthase. Journal of Biological Chemistry. 2016;291(2):572–81.

Artigos

Marques C, Santos-Silva C, Rodrigues C, Matos J, Moura T, Baptista MC, et al. Effect of different cocktails of cryoprotectants and calcium on bovine oocyte membrane permeability and cryosurvival. Reproduction In Domestic Animals. 2016;51(2, SI):114.

Outras Publicações Indexadas

Rodrigues C, Mósca AF, Martins AP, Nobre T, Prista C, Antunes F, et al. Rat aquaporin-5 is pH-gated induced by phosphorylation and is implicated in oxidative stress. International Journal of Molecular Sciences. 2016;17(12).

Artigos

Xavier JM, Rodrigues CMP, Solá S. Mitochondria: Major Regulators of Neural Development. Neuroscientist. 2016;22(4):346–58.

Artigos

Paterna A, Gomes SE, Borralho PM, Mulhovo S, Rodrigues CMP, Ferreira M-JU. Vobasinyl-Iboga Alkaloids from Tabernaemontana elegans: Cell Cycle Arrest and Apoptosis-Inducing Activity in HCT116 Colon Cancer Cells. Journal of Natural Products. 2016;79(10):2624–34.

Artigos

Gomes SE, Simões AES, Pereira DM, Castro RE, Rodrigues CMP, Borralho PM. miR-143 or miR-145 overexpression increases cetuximab-mediated antibody-dependent cellular cytotoxicity in human colon cancer cells. Oncotarget. 2016;7(8):9368–87.

Artigos

Florindo PR, Pereira DM, Borralho PM, Costa PJ, Piedade MFM, Rodrigues CMP, et al. New [(η5-C5H5)Ru(N-N)(PPh3)][PF6]compounds: Colon anticancer activity and GLUT-mediated cellular uptake of carbohydrate-appended complexes. Dalton Transactions. 2016;45(30):11926–30.

Artigos

Janota C, Lemere CA, Brito MA. Dissecting the Contribution of Vascular Alterations and Aging to Alzheimer’s Disease. Molecular Neurobiology. 2016;53(6):3793–811.

Artigos

Paterna A, Gomes SE, Borralho PM, Mulhovo S, Rodrigues CMP, Ferreira M-JU. (3′R)-hydroxytabernaelegantine C: A bisindole alkaloid with potent apoptosis inducing activity in colon (HCT116, SW620) and liver (HepG2) cancer cells. Journal of Ethnopharmacology. 2016;194:236–44.

Artigos

Magalhaes A, Matias I, Palmela I, Brito MA, Dias S. LDL-cholesterol increases the transcytosis of molecules through endothelial monolayers. PLoS ONE. 2016;11(10).

Artigos

Figueira M-E, Oliveira M, Direito R, Rocha J, Alves P, Serra A-T, et al. Protective effects of a blueberry extract in acute inflammation and collagen-induced arthritis in the rat. Biomedicine and Pharmacotherapy. 2016;83:1191–202.

Artigos

Houten SM, Violante S, Ventura FV, Wanders RJA. The Biochemistry and Physiology of Mitochondrial Fatty Acid β-Oxidation and Its Genetic Disorders. Annual Review of Physiology. 2016;78:23-44.

Artigos

Rodrigues CMP, Moshage H. Targeting TGR5 in cholangiocyte proliferation: Default topic. Gut. 2016;65(3):369–70.

Outras Publicações Indexadas

Moedas MF, van Cruchten AG, IJlst L, Kulik W, de Almeida IT, Diogo L, et al. Transient decrease of hepatic NAD+and amino acid alterations during treatment with valproate: new insights on drug-induced effects in vivo using targeted MS-based metabolomics. Metabolomics. 2016;12(8).

Artigos

Zarrouk O, Garcia-Tejero I, Pinto C, Genebra T, Sabir F, Prista C, et al. Aquaporins isoforms in cv. Touriga Nacional grapevine under water stress and recovery-Regulation of expression in leaves and roots. Agricultural Water Management. 2016 Jan;164(1, SI):167–75.

Artigos

Madeira A, Moura TF, Soveral G. Detecting aquaporin function and regulation. Frontiers in Chemistry. 2016;4(FEB).

Artigos

Bonito CA, Nunes J, Leandro J, Louro F, Leandro P, Ventura FV, et al. Unveiling the Pathogenic Molecular Mechanisms of the Most Common Variant (p.K329E) in Medium-Chain Acyl-CoA Dehydrogenase Deficiency by in Vitro and in Silico Approaches. Biochemistry. 2016;55(51):7086–98.

Artigos

Vale FF, Nunes A, Oleastro M, Gomes JP, Sampaio DA, Rocha R, et al. Genomes of Helicobacter pylori prophages. Helicobacter. 2016;21(1, SI):86.

Outras Publicações Indexadas

Morgado AL, Rodrigues CMP, Solá S. MicroRNA-145 Regulates Neural Stem Cell Differentiation Through the Sox2-Lin28/let-7 Signaling Pathway. Stem Cells. 2016;34(5):1386–95.

Artigos

Afonso MB, Rodrigues PM, Simao AL, Castro RE. Circulating microRNAs as Potential Biomarkers in Non-Alcoholic Fatty Liver Disease and Hepatocellular Carcinoma. Journal o Clinical Medicine. 2016 Mar;5(3).

Artigos

Sabir F, Loureiro-Dias MC, Prista C. Comparative analysis of sequences, polymorphisms and topology of yeasts aquaporins and aquaglyceroporins. FEMS Yeast Research. 2016;16(3).

Artigos

Bonito CA, Leandro P, Ventura FV, Guedes RC. Insights into Medium-chain Acyl-CoA Dehydrogenase Structure by Molecular Dynamics Simulations. Chemical Biology and Drug Design. 2016;88(2):281–92.

Artigos

Tenreiro MM, Malho R, Silveira M, Correia ML, Brito MA. A novel tool to monitor angiogenesis in bone marrow smears: detection and quantification of endothelial progenitor cells by multiple-labeling immunofluorescence analysis. Haematologica. 2016 Jun;101(1):782–3.

Outras Publicações Indexadas

Moutinho M, Nunes MJ, Correia JC, Gama MJ, Castro-Caldas M, Cedazo-Minguez A, et al. Neuronal cholesterol metabolism increases dendritic outgrowth and synaptic markers via a concerted action of GGTase-I and Trk. Scientific Reports. 2016;6.

Artigos

Direito I, Madeira A, Brito MA, Soveral G. Aquaporin-5: From structure to function and dysfunction in cancer. Cellular and Molecular Life Sciences. 2016;73(8):1623–40.

Artigos

2016
Menção Honrosa do Prémio APRH 2014/15
Melhor poster analítico no Encontro “Spring Conference: Phytochemicals, health & plant based nutrition, Nutrition Society 2016”
Prémio OIV 2016 na categoria Enologia

Contactos

Localização: Edifício F – 105
Tel.: +351 217 946 400
Extensão interna: 14342 e 14214
Correio eletrónico: cdctb@ff.ulisboa.pt | mrbronze@ff.ulisboa.pt

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