Helena Isabel Fialho Florindo Roque Ferreira
Associate Professor with Habilitation
Helena Florindo develops a multidisciplinary research focused on the rational development of functionalized nanobiomaterials to i) enhance antigen delivery to DC; ii) modulate antigen intracellular processing and presentation pathways; iii) block signalling pathways related to tumour evasion mechanisms. It includes the size-based targeting of lymph node-resident immune cells by NP to overcome major barriers for vaccine components and immunotherapies, as well as , the understanding of tumor stromal and immune cell interplay to guide the design of multi-targeting nano-conjugates as innovative immunotherapeutic treatments against metastatic cancer diseases.
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