Name
Ana Paula Costa dos Santos Peralta Leandro
Category
Assistant Professor with Habilitation
Department
BIOGRAPHICAL NOTE
Her scientific activity has been focused on the study of the biochemical and molecular basis of Inherited Metabolic Disorders (IEM). She developed experimental approaches for the expression and biochemical and biophysical characterization of variant proteins responsible for IEM (eg: phenylalanine hydroxylase; cystathionine β-synthase, medium chain acyl-CoA dehydrogenase) aiming the study of the negative interallelic complementation phenomenon; identification of the cellular molecular mechanisms of recognition and degradation of variant misfolded proteins (development of pharmacological therapies) and; optimization of enzyme stabilization conditions (development of enzymatic reposition therapies).