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Name

Ana Paula Costa dos Santos Peralta Leandro

Category

Assistant Professor

BIOGRAPHICAL NOTE

Her scientific activity has been focused on the study of the biochemical and molecular basis of Inherited Metabolic Disorders (IEM). She developed experimental approaches for the expression and biochemical and biophysical characterization of variant proteins responsible for IEM (eg: phenylalanine hydroxylase; cystathionine β-synthase, medium chain acyl-CoA dehydrogenase) aiming the study of the negative interallelic complementation phenomenon; identification of the cellular molecular mechanisms of recognition and degradation of variant misfolded proteins (development of pharmacological therapies) and; optimization of enzyme stabilization conditions (development of enzymatic reposition therapies).

Contacts

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14275
Location
Edifício F - 205
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