5th TRAINING COURSE, CA17-112 PRO EURO DILI NET | Novel Challenges in Toxicology

Goals and Learning Outcomes

Toxicological concepts are of utmost importance for all steps involved in drug discovery & development. Moreover, the new challenges associated with Toxicology are determinant for many other aspects of the biomedical sciences. By the end of this course it is expected that the students integrate the acquired knowledge towards complex toxicological phenomena and understand the impact f Toxicology in our modern society.

It is also expected that the students understand the adverse effects associated with the exposure of toxic xenobiotics from different classes and modes of action (MoA) as well as the inter-individual variations in biotransformation enzymes and membrane transporters, including the importance of genetic polymorphisms. Particular attention will be devoted to genotoxicity issues and their impact in carcinogenesis and in drug development. Safety issues in novel medicines, including biologicals, will also be highlighted. Moreover, the application and translation of advanced in vitro models (e.g. 3D cellular models) in the drug development process in the research and industry will be a key topic of the advanced course. Finally, the students should also understand the role of the Omics and potential of stem cell technology in predictive toxicology towards personalization.

Registration and Fees

Deadline for applications: 12th of September 2022



You can register in https://forms.office.com/r/9CHicgicbT

Once registered, an official invitation from e-cost will be sent to you

Course Coordinators


Joana Miranda
Nuno Oliveira



Learning Assessment

Learning Assessment:
Preparation and submission of an extended abstract in which the trainee is invited to address an emerging issue/challenge considered determinant for the development of toxicology or, in alternative, a pertinent concern related to a toxicological event going on in our days. The work will be done individually and should include not only the scientific background but also an opinion on the chosen topic.
The proposed work with a limit of 1 to 3 A4 pages written in Arial font size 11 and 1.5 spacing (including references) should be sent in a PDF format to jmiranda@ff.ul.pt and ngoliveira@ff.ul.pt until October 15th 2022.