Stem cell-based therapies are thriving. In fact, pharmaceutical companies are increasingly investing in stem cell technology to develop innovative and potentially valuable new treatments for severe human diseases, including cancer and neurological disorders, such as multiple sclerosis, Alzheimer´s and Parkinson´s disease, mood disorders, brain tumors and even stroke. Moreover, although seminal advances have occurred in understanding stem cell biology, further work is still needed to bridge the current gap between stem cell technologies and effective treatments in brain-related disorders. Stimulating the scientific interest on the topic will certainly accelerate and improve the successful transfer of stem cell-based discoveries from the bench to the bedside.