74. Lopes, P.A.*, Martins, R., da Silva, I.V., Madeira, M., Prates, J.A.M., Soveral, G.*
Modulation of aquaporin gene expression by n-3 long-chain PUFA lipid Q12 structures in white and brown adipose tissue from hamsters.
Br J Nutr, 2018
doi:10.1017/S0007114518002519
73. Ariz, I., Boeckstaens, M., Gouveia, C., Martins, A.P., Sanz-Luque, E., Fernández, E., Soveral, G., von Wirén, N., Marini, A.M., Aparicio-Tejo, P.M., Cruz, C.
Nitrogen isotope signature evidences ammonium deprotonation as a common transport mechanism for the AMT-Mep-Rh protein superfamily.
Sci Adv 4 (9), eaar3599, 2018.
doi: 10.1126/sciadv.aar3599
72. Gomes, A., da Silva, I.V., Rodrigues, C.M.P, Castro, R.E., Soveral, G.
The emerging role of microRNAs in aquaporin regulation.
Front Chem. 6:238, 2018.
doi: 10.3389/fchem.2018.00238
71. Méndez-Giménez L., Ezquerro S., da Silva I.V., Soveral G., Frühbeck G., Rodríguez A. Pancreatic Aquaporin-7: A Novel Target for Anti-diabetic Drugs? Front Chem. 2018;6:99, 2018.
doi: 10.3389/fchem.2018.00099
70. Marques, C.C., Santos-Silva, C., Rodrigues, C., Matos, J.E., Moura, T., Baptista, M.C. Horta, A.E.M., Bessa, R.J.B., Alves, S.P., Soveral, G., Pereira, R.M.L.N.
Bovine oocyte membrane permeability and cryosurvival: Effects of different cryoprotectants and calcium in the vitrification media.
Cryobiology, 81:4-11, 2018.
doi: 10.1016/j.cryobiol.2018.03.003
69. da Silva, I.V., Rodrigues, J.S., Rebelo, I., Miranda, J.P.G., Soveral, G.
Revisiting the metabolic syndrome: the emerging role of aquaglyceroporins.
Cell. Mol. Life Sci., 75:1973–1988, 2018.
doi:10.1007/s00018-018-2781-4
68. da Silva, I.V., Barroso, M., Moura, T., Castro, R., Soveral, G.
Endothelial Aquaporins and Hypomethylation: Potential Implications for Atherosclerosis and Cardiovascular Disease.
Int. J. Mol. Sci. 19(1), 130, 2018.
doi:10.3390/ijms19010130
67. Méndez-Giménez, L., Becerril, S., Camões, S., da Silva, I., Rodrigues, C., Moncada, R., Valenti, V., Catalan, V., Gomez-Ambrosi, J., Miranda, J., Soveral, G., Fruhbeck, G., Rodríguez, A.
Role of aquaporin-7 in ghrelin- and GLP-1-induced improvement of pancreatic β-cell function after sleeve gastrectomy in obese rats.
Int J Obes (Lond), 41(9):1394-1402, 2017.
doi: 10.1038/ijo.2017.135.
66. Sabir, F., Loureiro-Dias, M.C., Soveral, G., Prista, C.
Functional relevance of water and glycerol channels in Saccharomyces cerevisiae. FEMS Microbiol Lett, 364(9): fnx0802017, 2017.
doi: 10.1093/femsle/fnx080
65. Direito, I., Paulino, J., Vigia, E., Brito, M.A., Soveral, G.
Differential expression of aquaporin-3 and aquaporin-5 in pancreatic ductal adenocarcinoma.
J Surg Oncol, 115(8): 980-996, 2017.
doi: 10.1002/jso.24605
64. Rodrigues C, Tartaro Bujak I, Mihaljević B, Soveral, G., Cipak Gasparovic A.
Yeast aquaporin regulation by 4-hydroxynonenal is implicated in oxidative stress response.
IUBMB Life. 69(5):355-362, 2017.
doi: 10.1002/iub.1624
63. de Almeida, A., Mósca, A.F., Wragg, D., Wenzel, M., Kavanagh, P., Barone, G., Leoni, S., Soveral, G., Casini, A.
The mechanism of aquaporin inhibition by gold compounds elucidated by biophysical and computational methods.
Chem Commun (Camb), 53: 3830-3833, 2017.
doi: 10.1039/c7cc00318h
62. da Silva, I.V., Soveral, G.
Aquaporins in obesity.
Adv Exp Med Biol. 969:227-238, 2017.
doi: 10.1007/978-94-024-1057-0_15
61. Méndez-Giménez, L., Becerril, S., Moncada, R., Valenti, V., Fernández, S., Ramirez, B., Catalan, V., Gómez-Ambrosi, J., Soveral, G., Malagón, M.M., Diéguez, C., Rodríguez, A., Fruhbeck, G.
Gastric plication improves glycaemia partly by restoring the altered expression of aquaglyceroporins in adipose tissue and liver in obese rats.
Obes Surg. 27(7):1763-1774, 2017.
doi: 10.1007/s11695-016-2532-2.
60. Soveral, G., Casini, A.
Aquaporin modulators: a patent review (2010-2015).
Expert Opin Ther Pat., 27(1): 49-60, 2017
doi: 10.1080/13543776.2017.1236085
59. Lopes, P.A, Martins, A.P., Martins, S.V., Madeira, M.S., Santos, N.C., Moura, T.F.,
Prates, J.A.M., Soveral, G.
Higher membrane fluidity mediates the increased subcutaneous fatty acid content in pigs fed reduced protein diets.
Animal, 11(4): 713-719, 2017.
doi: 10.1017/S1751731116001968
58. Martins, S.V., Pires, V., Madeira, A., Nascimento, M., Alfaia, C.M., Castro, M.F., Soveral, G., Prates, J.A.M., Lopes, P.A. Novel anti-adipogenic properties of the individual trans8,cis10 conjugated linoleic acid (CLA) isomer in 3T3-L1 adipocytes.
Eur. J. Lipid Sci. Technol., 119: 1600042, 2017.
doi: 10.1002/ejlt.201600042
57. Rodrigues, C., Mósca, A.F., Martins, AP., Nobre, T., Prista, C., Antunes, F., Gasparovic, A.C., Soveral, G.
Rat Aquaporin-5 is pH-Gated Induced by Phosphorylation and is Implicated in Oxidative Stress.
Int. J. Mol. Sci. 17: 2090, 2016.
doi:10.3390/ijms17122090
56. Noronha H, Araújo D, Conde C, Martins AP, Soveral G, Chaumont F, Delrot, S, Gerós H. The Grapevine Uncharacterized Intrinsic Protein 1 (VvXIP1) Is Regulated by Drought Stress and Transports Glycerol, Hydrogen Peroxide, Heavy Metals but Not Water.
PLoS One 11(8):e0160976, 2016.
doi: 10.1371/journal.pone.0160976
55. Nave M., Castro, R.E., Rodrigues, C.M.P., Casini, A., Soveral, G., Gaspar. M.M. Nanoformulations of a potent copper-based aquaporin inhibitor with cytotoxic effect against cancer cells.
Nanomedicine, 1(14): 1817–1830, 2016.
doi: 10.2217/nnm-2016-0086
54. Estudante, M., Soveral, G., Morais, J., Benet, L.
Insights into Solute Carriers: Physiological Functions and Implications in Disease and Pharmacokinetics.
MedChemComm, 7: 1462-1478, 2016.
doi: 10.1039/C6MD00188B
53. de Almeida, A., Martins, A.P., Mósca, A.F., Wijma, H.J., Prista, C., Soveral, G., Casini, A
Exploring the gating mechanisms of aquaporin-3: new clues for the design of inhibitors?
MolBioSyst, 12: 1564-1573, 2016.
doi: 10.1039/C6MB00013D
52. Direito, I., Madeira. A., Brito, M.A., Soveral, G. Aquaporin 5: from structure to function and dysfunction in cancer.
Cell. Mol. Life Sci., 73: 1623-1640, 2016.
doi: 10.1007/s00018-016-2142-0
51. Madeira, A., Moura, T.F., Soveral, G. Detecting aquaporin function and regulation.
Front. Chem., 4: 3, 2016.
doi: 10.3389/fchem.2016.00003
50. Sabir F, Prista C, Madeira A, Moura T, Loureiro-Dias MC, Soveral G. Water transport in yeasts.
Adv. Exp. Med. Biol., 892: 107-124, 2016.
doi: 10.1007/978-3-319-25304-6_5
49. Madeira, A., Teresa F. Moura, T.F., Soveral, G. Aquaporin Functional Detection: Basic Concepts on Water and Solute Permeation.
in Aquaporins in health and disease : new molecular targets for drug discovery, G. Soveral, S. Nielsen, A. Casini, Eds.
CRC Press, Taylor & Francis Group, Boca Raton, FL, 2016.
48. G. Soveral, S. Nielsen, A. Casini, Eds.
Aquaporins in health and disease : new molecular targets for drug discovery.
CRC Press, Taylor & Francis Group, Boca Raton, FL, 2016. ISBN 9781498707831
47. Rodríguez, A, Rocío Moreno, N., Balaguer, I., Méndez-Giménez, L., Becerril, S., Catalán,
V., Gómez-Ambrosi, J., Portincasa, P., Calamita, G., Soveral, G., Malagón, M.M., Frühbeck, G. Leptin administration restores the altered adipose and hepatic expression of aquaglyceroporins improving the non-alcoholic fatty liver of ob/ob mice.
Sci. Rep., 5: 12067, 2015.
doi: 10.1038/srep12067
46. Molina-Hidalgo, F.J., Medina-Puche, L., Gelis, S., Ramos, J., Sabir, F., Soveral, G., Prista, C., Iglesias-Fernández, R., Caballeroa, J.L., Munoz-Blanco, J., Blanco-Portales, R. Functional characterization of FaNIP1;1 gene, a ripening-related and receptacle-specific aquaporin in strawberry fruit.
Plant Sci., 238: 198–211, 2015.
doi: 10.1016/j.plantsci.2015.06.013
45. Matos, J.E., Marques, C.C., Moura, T., Baptista, M.C., Horta, A.E.M., Soveral, G., Pereira, R.M.L.N. Conjugated linoleic acid improves oocyte cryosurvival through modulation of the cryoprotectants influx rate.
Reprod Biol Endocrinol., 13:60, 2015.
doi: 10.1186/s12958-015-0059-3
44. Martins, S.V., Madeira, A., Lopes, P.A, Pires, V.M., Alfaia, C.M., Prates, J.M., Moura, T.F., Soveral, G. Adipocyte membrane glycerol permeability is involved in the anti-adipogenic effect of conjugated linoleic acid.
Biochem. Biophys. Res. Commun., 458: 356-361, 2015.
doi: 10.1016/j.bbrc.2015.01.116
43. Madeira, A., Mósca, A.F., Moura, T.F., Soveral, G. Aquaporin-5 is expressed in adipocytes with implications in adipose tissue differentiation.
IUBMB life, 67:54-60, 2015.
doi: 10.1002/iub.1345
42. Madeira, A., Moura, T.F., Soveral, G. Aquaglyceroporins: implications in adipose biology and obesity.
Cell. Mol. Life Sci., 2:759–771, 2015.
doi: 10.1007/s00018-014-1773-2
41. de Almeida, A., Soveral, G., Casini A. Gold compounds as aquaporin inhibitors: new opportunities for therapy and imaging.
Med. Chem. Commun., 5, 1444-1453, 2014.
doi: 10.1039/c4md00265b
40. Sabir, F., Leandro, M.J., Martins, A.P., Loureiro-Dias, M-C., Moura, T.F, Soveral, G., Prista, C. Exploring three PIPs and three TIPs of grapevine for transport of water and atypical substrates through heterologous expression in aqy-null yeast.
PLoS ONE, 9(8):e102087, 2014.
doi: 10.1371/journal.pone.0102087
39. Leitão, L., Prista, C., Loureiro-Dias, M.C., Moura, T.F., Soveral, G. The grapevine tonoplast aquaporin TIP2;1 is a pressure gated water channel.
Biochem. Biophys. Res. Commun., 450: 289–294, 2014.
doi: 10.1016/j.bbrc.2014.05.121
38. Madeira, A., Fernandez-Veledo, S., Camps, M., Zorzano, A., Moura, T.F., Ceperuelo-Mallafre, V., Vendrell, J., Soveral, G. Human Aquaporin-11 Is a Water and Glycerol Channel and Localizes in the Vicinity of Lipid Droplets in Human Adipocytes.
Obesity, 22, 2010–2017, 2014.
doi:10.1002/oby.20792
37. Madeira, A., de Almeida, A., de Graaf, C., Camps, M., Zorzano, A., Moura, T.F., Casini, A., Soveral, G. A gold coordination compound as a chemical probe to unravel aquaporin-7 function.
ChemBioChem, 15: 1487–1494, 2014.
doi: 10.1002/cbic.201402103
36. Serna, A., Galán-Cobo, A., Rodrigues, C., Sánchez-Gomar, I., Toledo-Aral, J.J., Moura, T.F., Casini, A., Soveral, G., Echevarría, M. Functional inhibition of aquaporin-3 with a gold-based compound induces blockage of cell proliferation.
-
J.Cell. Physiol. 229(11): 1787-1801, 2014.
doi: 10.1002/jcp.24632
35. Noronha, H., Agasse, A., Martins. A.P., Berny, M., Gomes, D., Thiebaud, P., Delrot, S., Soveral, G., Chaumont, F., Gerós, H. The grape aquaporin VvSIP1 transports water across the ER membrane.
J. Exp. Bot., 65(4):981-93, 2014.
doi: 10.1093/jxb/ert448
34. Madeira, A., Camps, M., Moura, T.F., Zorzano, A., Soveral, G. Biophysical assessment of human aquaporin-7 as a water and glycerol channel in 3T3-L1 adipocytes.
PLoS ONE, 8(12): e83442, 2013.
doi: 10.1371/journal.pone.0083442
33. Estudante, M., Maya, M., Morais, J.A.G, Soveral, G., Benet, L.Z. Effect of P-glycoprotein
on the rat intestinal permeability and metabolism of the BDDCS class 1 drug verapamil.
Mol. Pharmaceutics, 10 (11): 4038–4045, 2013.
doi: 10.1021/mp400381p
32. Martins, A.P., Ciancetta, A., de Almeida, A., Marrone, A., Re, N., Soveral, G., Casini, A. Aquaporin inhibition by gold(III) compounds: new insights.
ChemMedChem., 8: 1086-1092, 2013.
doi: 10.1002/cmdc.201300107
31. de Almeida, A., Oliveira, B.L., Correia, J.D.G., Soveral, G., Casini, A. Emerging protein targets for metal-based pharmaceutical agents: an update.
Coord. Chem. Rev., 257: 2689-2704, 2013.
doi: 10.1016/j.ccr.2013.01.031
30. Estudante, M., Morais, J.A., Soveral, G., Benet, L.Z. Intestinal drug transporters: an
overview.
Adv. Drug Deliv. Rev., 65:1340-1356, 2013.
doi: 10.1016/j.addr.2012.09.042
29. Dias, C., Testa, B., Soveral, G., Dias, M., Constantino, L. Effect of some common drugs
on alcohol metabolism in rat liver preparations.
Toxicology in Vitro, 26: 1177-1180, 2012.
doi: 10.1016/j.tiv.2012.06.011
28. Martins, A.P., Lopes, P.A., Madeira, M.S., Martins, S.V., Santos, N.C., Moura, T.F., Prates, J.A., Soveral, G. Differences in lipid deposition and adipose membrane biophysical properties from lean and obese pigs under dietary protein restriction.
Biochem. Biophys. Res. Commun. 423: 170–175, 2012.
doi: 10.1016/j.bbrc.2012.05.108
27. Martins, A.P., Marrone, A., Ciancetta, A., Galán-Cobo, A., Echevarría, M., Moura, T.F., Re, N., Casini, A., Soveral, G. Targeting Aquaporin Function: Potent Inhibition of Aquaglyceroporin-3 by a Gold-based Compound.
PLoS ONE 7(5): e37435, 2012.
doi: 10.1371/journal.pone.0037435
26. Leitão, L., Prista, C., Moura, T.F., Loureiro-Dias, M.C., Soveral, G. Grapevine Aquaporins: Gating of a Tonoplast Intrinsic Protein (TIP2;1) by Cytosolic pH.
PLoS ONE 7(3): e33219, 2012.
doi: 10.1371/journal.pone.0033219
25. Rodríguez, I.A., Silva, R.S., Martins, A.P., Soveral, G., López-Barneo, J., Aral, J.J., Echevarría, M. Functional and transcriptional induction of Aquaporin-1 gene by hypoxia; analysis of promoter and role of Hif-1.
PLoS ONE 6(12): e28385, 2011.
doi: 10.1371/journal.pone.0028385
24. Martins, A.P., Lopes, P.A., Costa, A.S., Martins, S.V., Santos, N.C., Prates, J.A., Moura, T.F., Soveral, G. Differential mesenteric fat deposition in bovines fed on silage or concentrate is independent of glycerol membrane permeability.
Animal, 5: 1949-1956, 2011.
doi: 10.1017/S1751731111001091
23. Soveral, G., Trincão, J., Moura, T.F. Aquaporins: membrane channels for water transport. Canal BQ (Revista online da Sociedade Portuguesa de Bioquímica), 7: 36-43, 2011.
http://canalbq.spb.pt/docs/canalBQ_0008-36-43.pdf
22. Campos, E., Moura, T.F., Oliva, A., Leandro, P., Soveral G. Lack of Aquaporin 3 in bovine erythrocyte membranes correlates with low glycerol permeation.
Biochem. Biophys. Res. Commun. 408: 477-481, 2011.
doi: 10.1016/j.bbrc.2011.04.057
21. Soveral, G., Prista, C., Moura, T.F., Loureiro-Dias, M.C. Yeast water channels: an overview of orthodox aquaporins.
Biol. Cell 103: 35-54, 2010.
doi: 10.1042/BC20100102
20. Martins, A.P., Lopes, P.A., Martins, S.V., Madeira, A., Santos, N.C., Prates, J., Moura, T., Soveral, G. Conjugated Linoleic Acid Reduces Permeability and Fluidity of Adipose Plasma Membranes from Obese Zucker Rats.
Biochem. Biophys. Res. Commun. 398:199-204, 2010.
doi: 10.1016/j.bbrc.2010.06.059
19. Madeira, A., Leitão, L., Soveral, G. Dias, P., Prista, C., Moura, T., Loureiro-Dias, M.C. Effect of Ethanol on Fluxes of Water and Protons across the Plasma Membrane of Saccharomyces cerevisiae.
FEMS Yeast Res. 10: 252-258, 2010.
doi: 10.1111/j.1567-1364.2010.00607.x
18. Soveral, G., Martins, A.P., Martins, S.V., Lopes, P., Alfaia, C., Prates, J., Moura, T. Effect of dietary conjugated linoleic acid isomers on water and glycerol permeability of kidney membranes.
Biochem. Biophys. Res. Commun. 383:108-112, 2009.
doi: 10.1016/j.bbrc.2009.03.136
17. Soveral, G., Madeira, A., Loureiro-Dias, M.C., and Moura, T. Membrane tension regulates water transport in yeast.
Biochim. Biophys. Acta Biomembranes 1778: 2573-2579, 2008.
doi: 10.1016/j.bbamem.2008.07.018
16. Aires, C.C.P., Soveral, G., Luís, P., ten Brink, H.J., Tavares de Almeida, I., Duran, M., Wanders, R, Silva, M.B. Pyruvate uptake is inhibited by valproic acid and metabolites in mitochondrial membranes.
FEBS Lett. 582:3359-3366, 2008.
doi: 10.1016/j.febslet.2008.08.028
15. Martins, S.V., Lopes, P.A., Alfaia, C.M., Ribeiro, V.S., Guerreiro, T.V., Fontes, C.M., Castro, M.F., Soveral, G., Prates, J.A.M. Contents of conjugated linoleic acid isomers in ruminant-derived foods and estimation of their contribution to daily intake in Portugal.
Br. J. Nutr. 19: 1-8, 2007.
doi: 10.1017/S0007114507781448
14. Luís P., Ruiter, J., Aires, C., Soveral, G., Tavares de Almeida, I., Duran, M., Wanders, R., Silva, M.B. Valproic acid metabolites inhibit dihydrolipoyl dehydrogenase activity leading to impaired 2-oxoglutarate-driven oxidative phosphorylation.
Biochim. Biophys. Acta Bioenergetics 1767: 1126–1133, 2007.
doi: 10.1016/j.bbabio.2007.06.007
13. Soveral, G., Madeira, A., Loureiro-Dias, M.C., P. Moura, T. Water Transport in Intact Yeast Cells Assessed by Fluorescence Self Quenching.
Appl. Environ. Microbiol. 73: 2341-2343, 2007.
doi: 10.1128/AEM.02519-06
12. Mendes, L, Rodrigues, C., Castro, M., Soveral, G. Essential mineral and toxic elements present in the tea soft drink.
Electron. J. Environ. Agric. Food Chem. 5: 1624-1628, 2006.
11. Mendes, L., Castro, M., Soveral, G. Leite materno e o mercúrio.
Boletim da APNEP 9: 35-40, 2006.
10. Soveral, G., Veiga, A., Loureiro-Dias, M.C., Van Dijck, P. Moura, T. Water channels are important for osmotic adjustments of yeast cells at low temperature.
Microbiology-SGM 152: 1515-1521, 2006.
doi: 10.1099/mic.0.28679-0
9. Soveral, G., Lopes, F., Ferreira, C., Cabrita, J. Estilo de vida e obesidade em adolescentes da região de Lisboa.
Rev. Lusófona de Ciências e Tecnologias da Saúde 2: 109-115, 2005.
8. Conceição T., Faria N., Pimentel M., Soveral G., Duarte A., Lito L., Melo Cristino J., Salgado, M.J. New chromosomal AmpC b-lactamase in Enterobacter cloacae.
Antimicrob. Agents Chemother. 48: 1437-1437, 2004.
doi: 10.1128/AAC.48.4.1437.2004
7. Barroso, H., Freitas-Vieira, A.,Lito, L.M., Melo Cristino, J., Salgado, M.J., Ferreira, H.,
Sousa, J.C., Soveral, G., Moura, T., Duarte A. Survey of Klebsiella pneumoniae producing extended-spectrum b-lactamases at a portuguese hospital: TEM-10 as the endemic enzyme. J. of Antimicrobial Chemotherapy 45, 611-616, 2000.
doi: 10.1093/jac/45.5.611
6. Alves, P., Soveral, G., Macey, R. and Moura, T. Kinetics of Water Transport in Eel Intestinal Vesicles.
-
J.Membr. Biol. 171, 177-182, 1999.
doi: 10.1007/s002329900569
5. Alves, P., Soveral, G., Macey, R. and Moura, T. Osmotic Equilibrium and Elastic Properties of Eel Intestinal Vesicles.
-
J.Membr. Biol. 171, 171-176, 1999.
doi: 10.1007/s002329900568
4. Soveral, G., Macey, R. I. and Moura, T. F. Membrane stress causes inhibition of water channels in brush border membrane vesicles from kidney proximal tubule.
Biol. Cell. 89, 275-282, 1997.
doi: 10.1016/S0248-4900(97)83379-5
3. Soveral, G., Macey, R. I. and Moura, T. F. Water permeability of brush border membrane vesicles from kidney proximal tubule.
-
J.Membr. Biol. 158, 219-228, 1997.
doi: 10.1007/s002329900259
2. Soveral, G., Macey, R. I. and Moura, T. F. Mechanical properties of brush border membrane vesicles from kidney proximal tubule.
J. Membr. Biol. 158, 209-217, 1997.
doi: 10.1007/s002329900258
1. Soveral-Rodrigues, M.G., Santos, M.H. Teores de Ácido N-acetilneuramínico em crianças e adultos normais. Rev. Port. Farm., 36, 3-4: 43-45, 1985.