Química Farmacêutica e Terapêutica

Principais Atividades

Ensino de 1.º, 2.º e 3.º ciclos.
Investigação científica e desenvolvimento tecnológico.
Serviços de extensão universitária:
            serviços ao exterior
            atividades complementares no domínio da formação contínua e da promoção da inovação.

Órgãos

Presidente
Maria José Umbelino Ferreira

Comissão Executiva de Departamento
Carlos Alberto Mateus Afonso
Francisca Conceição Lopes
Maria José Umbelino Ferreira
Maria Henriques Lourenço Ribeiro
Rui Ferreira Alves Moreira

Comissão de Departamento
A Comissão de Departamento é constituída pelos Doutores do DQFT com vínculo à FFUL.

Investigação

Instituto de Investigação do Medicamento (iMed.ULisboa)
            Grupos de Investigação:
            Química Medicinal 
            Química Bioorgânica
            Química de Produtos Naturais
            Química Biológica e Toxicológica

2017

ReferênciaTipo de Documento
Santos CAT, Páscoa RNMJ, Lopes JA. Applications of FTIR Spectroscopy in the Wine Industry. In: Moore E, editor. Fourier transform infrared spectroscopy (FTIR) : methods, analysis, and research insights. New York: Nova Science Publishers; 2017. p. 79–120.

Livros e Capítulos de Livros

Pinheiro L, Faustino C. Amino Acid-Based Surfactants for Biomedical Applications. In: Reza Najjar, editor. Application and Characterization of Surfactants. London: InTech; 2017.

Livros e Capítulos de Livros

Paulo A, Castillo C, Neidle S. Targeting Promoter Quadruplex Nucleic Acids for Cancer Therapy. In: Chackalamannil S, Rotella D, Ward S, editors. Comprehensive medicinal chemistry III. Amsterdam: Elsevier; 2017. p. 308–40.

Livros e Capítulos de Livros

Ismaili L, Romero A, Carreiras MC, Marco-Contelles J. Multitarget-Directed Antioxidants as Therapeutic Agents. In: Michael Decker, editor. Design of Hybrid Molecules for Drug Development. Amsterdam: Elsevier; 2017. p. 5–46.

Livros e Capítulos de Livros

Zomorodian A, Ribeiro IA, Fernandes JCS, Matos AC, Santos C, Bettencourt AF, et al. Biopolymeric coatings for delivery of antibiotic and controlled degradation of bioresorbable Mg AZ31 alloys. International Journal of Polymeric Materials and Polymeric Biomaterials. 2017;66(11):533–43

Artigos

Vicente AI, Esteves T, Afonso CAM, Ferreira FC. Solvent compatible polymer functionalization with adenine, a DNA base, for API degenotoxification: Preparation and characterization. Separation and Purification Technology. 2017;179:438–48

Artigos

Vicente AI, Coelho JAS, Simeonov SP, Lazarova HI, Popova MD, Afonso CAM. Oxidation of 5-Chloromethylfurfural (CMF) to 2,5-Diformylfuran (DFF). Molecules. 2017;22(2)

Artigos

Teixeira FA, Marcos PM, Ascenso JR, Brancatelli G, Hickey N, Geremia S. Selective Binding of Spherical and Linear Anions by Tetraphenyl(thio)urea-Based Dihomooxacalix[4]arene Receptors. Journal of Organic Chemistry. 2017;82(21):11383–90

Artigos

Sousa A, Santos F, Gaspar MM, Calado S, Pereira JD, Mendes E, et al. The selective cytotoxicity of new triazene compounds to human melanoma cells. Bioorganic and Medicinal Chemistry. 2017;25(15):3900–10

Artigos

Soengas RG, Da Silva G, Estévez JC. Synthesis of spironucleosides: Past and future perspectives. Molecules. 2017;22(11)

Artigos

Soares J, Espadinha M, Raimundo L, Ramos H, Gomes AS, Gomes S, et al. DIMP53-1: a novel small-molecule dual inhibitor of p53-MDM2/X interactions with multifunctional p53-dependent anticancer properties. Molecular Oncology. 2017 Jun;11(6):612–27

Artigos

Sitarek P, Rijo P, Garcia C, Skała E, Kalemba D, Białas AJ, et al. Antibacterial, Anti-Inflammatory, Antioxidant, and Antiproliferative Properties of Essential Oils from Hairy and Normal Roots of Leonurus sibiricus L. And Their Chemical Composition. Oxidative Medicine and Cellular Longevity. 2017;2017

Artigos

Sintra TE, Nasirpour M, Siopa F, Rosatella AA, Gonçalves F, Coutinho JAP, et al. Ecotoxicological evaluation of magnetic ionic liquids. Ecotoxicology and Environmental Safety. 2017;143:315–21

Artigos

Simoes NG, Bettencourt AF, Monge N, Ribeiro IAC. Novel antibacterial agents: An emergent need to win the battle against infections. Mini-Reviews in Medicinal Chemistry. 2017;17(14):1364–76

Artigos

Scapin E, Frizzo CP, Rodrigues LV, Zimmer GC, Vaucher RA, Sagrillo MR, et al. Synthesis, antimicrobial activity and cytotoxic investigation of novel trifluoromethylated tetrazolo[1,5-a]pyrimidines. Medicinal Chemistry Research. 2017;26(3):640–9

Artigos

Santos FMF, Matos AI, Ventura AE, Gonçalves J, Veiros LF, Florindo HF, et al. Modular Assembly of Reversible Multivalent Cancer-Cell-Targeting Drug Conjugates. Angewandte Chemie - International Edition. 2017;56(32):9346–50

Artigos

Roque L, Molpeceres J, Reis C, Rijo P, Reis CP. Past, recent progresses and future perspectives of nanotechnology applied to antifungal agents. Current Drug Metabolism. 2017;18(4):280–90

Artigos

Rodrigues PM, Afonso MB, Simaõ AL, Carvalho CC, Trindade A, Duarte A, et al. MiR-21 ablation and obeticholic acid ameliorate nonalcoholic steatohepatitis in mice. Cell Death and Disease. 2017;8(4)

Artigos

Rodrigues CAB, Misale A, Schiel F, Maulide N. Direct synthesis of γ-pyrones by electrophilic condensation of β-ketoesters. Organic and Biomolecular Chemistry. 2017;15(3):680–3

Artigos

Rocha Â, Teixeira R, Lourenço NMT, Afonso CAM. Enzymatic Kinetic Resolution of Secondary Alcohols Using an Ionic Anhydride Generated In Situ. ChemSusChem. 2017;10(1):296–302

Artigos

Ribeiro CJA, Nunes RC, Amaral JD, Gonçalves LM, Rodrigues CMP, Moreira R, et al. Spirotriazoline oxindoles: A novel chemical scaffold with in vitro anticancer properties. European Journal of Medicinal Chemistry. 2017;140:494–509

Artigos

Restolho J, Barroso M, Saramago B, Dias M, Afonso CAM. Contactless decontamination of hair samples: cannabinoids. Drug Testing and Analysis. 2017;9(2):282–8

Artigos

Reis MA, Ahmed OB, Spengler G, Molnár J, Lage H, Ferreira M-JU. Exploring Jolkinol D Derivatives to Overcome Multidrug Resistance in Cancer. Journal of Natural Products. 2017;80(5):1411–20

Artigos

Rebelo A, Molpeceres J, Rijo P, Reis CP. Pancreatic cancer therapy review: From classic therapeutic agents to modern nanotechnologies. Current Drug Metabolism. 2017;18(4):346–59

Artigos

Ravasco JMJM, Monteiro CM, Trindade AF. Cyclopropenes: A new tool for the study of biological systems. Organic Chemistry Frontiers. 2017;4(6):1167–98

Artigos

2016

ReferênciaTipo de Documento
Wiśniewski J, Wesołowska O, Środa-Pomianek K, Paprocka M, Bielawska-Pohl A, Krawczenko A, et al. Euphorbia species-derived diterpenes and coumarins as multidrug resistance modulators in human colon carcinoma cells. Anticancer Research. 2016;36(5):2259–64.

Artigos

Valente E, Dias C, Constantino L. Acetylation of Cholesterol and Purification by Column Chromatography. In: Comprehensive Organic Chemistry Experiments for the Laboratory Classroom. London: Royal Society of Chemistry; 2016. p. 142–6.

Livros e Capítulos de Livros

Lourenço N, Monteiro C, Afonso CAM. Enzymatic Kinetic Resolution and Preparative Separation of Secondary Alcohols. In: Comprehensive Organic Chemistry Experiments for the Laboratory Classroom. London: Royal Society of Chemistry; 2016. p. 927–30.

Livros e Capítulos de Livros

Pontes C, Alves M, Santos C, Ribeiro MH, Gonçalves L, Bettencourt AF, et al. Can Sophorolipids prevent biofilm formation on silicone catheter tubes? International Journal of Pharmaceutics. 2016;513(1–2):697–708.

Artigos

Siopa F, Figueiredo T, Frade RFM, Neto I, Meirinhos A, Reis CP, et al. Choline-Based Ionic Liquids: Improvement of Antimicrobial Activity. ChemistrySelect. 2016;1(18):5909–16.

Artigos

Akkapeddi P, Azizi S-A, Freedy AM, Cal PMSD, Gois PMP, Bernardes GJL. Construction of homogeneous antibody-drug conjugates using site-selective protein chemistry. Chemical Science. 2016;7(5):2954–63.

Artigos

Dourado J, Pérez M, Griera R, Santos MMM. Asymmetric Cyclocondensation Reaction Induced by Chiral Aminoalcohol. In: Comprehensive Organic Chemistry Experiments for the Laboratory Classroom. 2016. p. 198–201.

Livros e Capítulos de Livros

Ventura SPM, De Morais P, Coelho JAS, Sintra T, Coutinho JAP, Afonso CAM. Evaluating the toxicity of biomass derived platform chemicals. Green Chemistry. 2016;18(17):4733–42.

Artigos

Valente E, Dias C, Constantino L. A SN1 Reaction: Synthesis of tert-Butyl Chloride. In: Comprehensive Organic Chemistry Experiments for the Laboratory Classroom. London: Royal Society of Chemistry; 2016. p. 56–60.

Livros e Capítulos de Livros

Lucas SD, Ruivo EFP, Figueiras M, Lavrado JP, Moreira R. Click Chemistry. In: Comprehensive Organic Chemistry Experiments for the Laboratory Classroom. London: Royal Society of Chemistry; 2016. p. 668–70.

Livros e Capítulos de Livros

Ramalhete C, Mulhovo S, Molnar J, Ferreira M-JU. Triterpenoids from Momordica balsamina: Reversal of ABCB1-mediated multidrug resistance. Bioorganic and Medicinal Chemistry. 2016;24(21):5061–7.

Artigos

Skaba E, Rijo P, Garcia C, Sitarek P, Kalemba D, Toma M, et al. The essential oils of rhaponticum carthamoides hairy roots and roots of soil-grown plants: Chemical composition and antimicrobial, anti-inflammatory, and antioxidant activities. Oxidative Medicine and Cellular Longevity. 2016;2016.

Artigos

Candeias NR, Paterna R, Gois PMP. Homologation Reaction of Ketones with Diazo Compounds. Chemical Reviews. 2016;116(5):2937–81.

Artigos

Duarte A, Carrasco M, Ressurreição A. Synthesis of Aurone Derrivatives Through Acid-Catalysed Aldol Condensation. In: Comprehensive Organic Chemistry Experiments for the Laboratory Classroom. London: Royal Society of Chemistry; 2016. p. 352–4.

Livros e Capítulos de Livros

Vale JR, Siopa F, Branco PS, Afonso CAM. Ring Opening of 6-Azabicyclo[3.1.0]hex-3-en-2-ols in Water under Mild Conditions. European Journal of Organic Chemistry. 2016;2016(11):2048–53.

Artigos

Vale J, Afonso CAM. Grignard-Like Reaction in Water. In: Comprehensive Organic Chemistry Experiments for the Laboratory Classroom. London: Royal Society of Chemistry; 2016. p. 316–8.

Livros e Capítulos de Livros

Madureira AM, Ferreira MJU. Thin layer chromatography of plants pigments. In: Comprehensive Organic Chemistry Experiments for the Laboratory Classroom. London: Royal Society of Chemistry; 2016. p. 18–22.

Livros e Capítulos de Livros

Reis MA, Ahmed OB, Spengler G, Molnár J, Lage H, Ferreira M-JU. Jatrophane diterpenes and cancer multidrug resistance - ABCB1 efflux modulation and selective cell death induction. Phytomedicine. 2016;23(9):968–78.

Artigos

Faustino H, Silva MJSA, Veiros LF, Bernardes GJL, Gois PMP. Iminoboronates are efficient intermediates for selective, rapid and reversible N-terminal cysteine functionalisation. Chemical Science. 2016;7(8):5052–8.

Artigos

Faustino C, Serafim C, Rijo P, Reis CP. Bile acids and bile acid derivatives: use in drug delivery systems and as therapeutic agents. Expert Opinion on Drug Delivery. 2016;13(8):1133–48.

Artigos

Estevão MS, Afonso CAM. Effect of a catalyst in the Acylation of Alcohols with Acetic Anhydride: manipulation of a natural aroma. In: Comprehensive Organic Chemistry Experiments for the Laboratory Classroom. London: Royal Society of Chemistry; 2016. p. 169–71.

Livros e Capítulos de Livros

Uriel C, Rijo P, Fernandes AS, Gómez AM, Fraser-Reid B, López JC. Methyl 1,2-Orthoesters in Acid-Washed Molecular Sieves Mediated Glycosylations. ChemistrySelect. 2016;1(18):6011–5.

Artigos

Guerreiro PS, Estácio SG, Antunes F, Fernandes AS, Pinheiro PF, Costa JG, et al. Structure-based virtual screening toward the discovery of novel inhibitors of the DNA repair activity of the human apurinic/apyrimidinic endonuclease 1. Chemical Biology and Drug Design. 2016;88(6):915–25.

Artigos

Madureira AM, Santana A, Valente V, Ferreira MJU. Synthesis of Dibenzalacetone 2,4-Dinitrophenylhydrazone. In: Comprehensive Organic Chemistry Experiments for the Laboratory Classroom. London: Royal Society of Chemistry; 2016. p. 272–6.

Livros e Capítulos de Livros

Ribeiro CJA, Amaral JD, Rodrigues CMP, Moreira R, Santos MMM. Spirooxadiazoline oxindoles with promising in vitro antitumor activities. MedChemComm. 2016;7(3):420–5.

Artigos

Contactos

Edifício H
Tel.: 217 946 400
Ext.: 14379
Correio eletrónico: mjuferreira@ff.ulisboa.pt

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