Química Farmacêutica e Terapêutica

Principais Atividades

Ensino de 1.º, 2.º e 3.º ciclos.
Investigação científica e desenvolvimento tecnológico.
Serviços de extensão universitária:
            serviços ao exterior
            atividades complementares no domínio da formação contínua e da promoção da inovação.


Maria José Umbelino Ferreira

Comissão Executiva de Departamento
Carlos Alberto Mateus Afonso
Francisca Conceição Lopes
Maria José Umbelino Ferreira
Maria Henriques Lourenço Ribeiro
Rui Ferreira Alves Moreira

Comissão de Departamento
A Comissão de Departamento é constituída pelos Doutores do DQFT com vínculo à FFUL.


Instituto de Investigação do Medicamento (iMed.ULisboa)
            Grupos de Investigação:
            Química Medicinal 
            Química Bioorgânica
            Química de Produtos Naturais
            Química Biológica e Toxicológica



  • Afonso CAM. Comprehensive organic chemistry experiments for the laboratory classroom [Internet]. Cambridge: Royal Society of Chemistry; 2017
  • Alcaide MM, Santos FMF, Pais VF, Carvalho JI, Collado D, Pérez-Inestrosa E, et al. Electronic and Functional Scope of Boronic Acid Derived Salicylidenehydrazone (BASHY) Complexes as Fluorescent Dyes. Journal of Organic Chemistry. 2017;82(14):7151–8.
  • Alegre-Gómez S, Sainz P, Simões MF, Rijo P, Moiteiro C, González-Coloma A, et al. Antiparasitic Activity of Diterpenoids Against Trypanosoma cruzi. Planta Medica. 2017;83(3–4):306–11.
  • Beira M, Daniel CI, Almeida PL, Corvo MC, Rosatella AA, Afonso CAM, et al. 1H NMR Relaxometry and Diffusometry Study of Magnetic and Nonmagnetic Ionic Liquid-Based Solutions: Cosolvent and Temperature Effects. Journal of Physical Chemistry B. 2017;121(51):11472–84.
  • Cal PMSD, Sieglitz F, Santos FMF, Parente Carvalho C, Guerreiro A, Bertoldo JB, et al. Site-selective installation of BASHY fluorescent dyes to Annexin V for targeted detection of apoptotic cells. Chemical Communications. 2017;53(2):368–71.
  • Da Silva G, Soengas RG. Natural occurrence, synthesis and biological applications of spermidine alkaloids. Current Organic Chemistry. 2017;21(6):546–58.
  • De Almeida TS, Júlio A, Mota JP, Rijo P, Reis CP. An emerging integration between ionic liquids and nanotechnology: General uses and future prospects in drug delivery. Therapeutic Delivery. 2017;8(6):461–73.
  • Di Maria S, Belchior A, Pereira E, Quental L, Oliveira MC, Mendes F, et al. Dosimetry assessment of DNA damage by Auger-emitting radionuclides: Experimental and Monte Carlo studies. Radiation Physics and Chemistry. 2017;140:278–82.
  • Espadinha M, Dourado J, Lajarin-Cuesta R, Herrera-Arozamena C, Gonçalves LMD, Rodríguez-Franco MI, et al. Optimization of Bicyclic Lactam Derivatives as NMDA Receptor Antagonists. ChemMedChem. 2017;12(7):537–45.
  • Estevão MS, Afonso CAM. Synthesis of trans-4,5-diaminocyclopent-2-enones from furfural catalyzed by Er(III) immobilized on silica. Tetrahedron Letters. 2017;58(4):302–4.
  • Estevão MS, Martins RJV, Afonso CAM. Synthesis of trans-4,5-Bis-dibenzylaminocyclopent-2-enone from Furfural Catalyzed by ErCl3·6H2O. Journal of Chemical Education. 2017;94(10):1587–9.
  • Falcão AS, Carvalho LAR, Lidónio G, Vaz AR, Lucas SD, Moreira R, et al. Dipeptidyl Vinyl Sulfone as a Novel Chemical Tool to Inhibit HMGB1/NLRP3-Inflammasome and Inflamma-miRs in Aβ-Mediated Microglial Inflammation. ACS Chemical Neuroscience. 2017;8(1):89–99.
  • Faustino C, Rijo P, Reis CP. Nanotechnological strategies for nerve growth factor delivery: Therapeutic implications in Alzheimer’s disease. Pharmacological Research. 2017;120:68–87.
  • Ferreira RJ, Bonito CA, Cordeiro MNDS, Ferreira M-JU, Dos Santos DJVA. Structure-function relationships in ABCG2: Insights from molecular dynamics simulations and molecular docking studies. Scientific Reports. 2017;7(1).
  • Ferreira RJ, Bonito CA, Ferreira MJU, dos Santos DJVA. About P-glycoprotein: a new drugable domain is emerging from structural data. Wiley Interdisciplinary Reviews: Computational Molecular Science. 2017;7(5).
  • Florindo PR, Costa PJ, Piedade MFM, Paula Robalo M. pH-Switchability and Second-Order Nonlinear Optical Properties of Monocyclopentadienylruthenium(II)/iron(II) Tetrazoles/Tetrazolates: Synthesis, Characterization, and Time-Dependent Density Functional Theory Calculations. Inorganic Chemistry. 2017 Jun;56(12):6849–63.
  • Francisco AP, Paulo A. Oncogene Expression Modulation in Cancer Cell Lines by DNA G-Quadruplex-Interactive Small Molecules. Current Medicinal Chemistry. 2017;24(42):4873–904.
  • Gawali VS, Simeonov S, Drescher M, Knott T, Scheel O, Kudolo J, et al. C2-Modified Sparteine Derivatives Are a New Class of Potentially Long-Acting Sodium Channel Blockers. ChemMedChem. 2017;12(22):1819–22.
  • Ismaili L, Carreiras MC. Multicomponent reactions for multitargeted compounds for alzheimer`s disease. Current Topics in Medicinal Chemistry. 2017;17(31):3319–27.
  • Ismaili L, Romero A, Carreiras MC, Marco-Contelles J. Multitarget-Directed Antioxidants as Therapeutic Agents. In: Michael Decker, editor. Design of Hybrid Molecules for Drug Development. Amsterdam: Elsevier; 2017. p. 5–46.
  • Ismaili L, Romero A, do Carmo Carreiras M, Marco-Contelles J. Multitarget-Directed Antioxidants as Therapeutic Agents: Putting the Focus on the Oxidative Stress. Design of Hybrid Molecules for Drug Development. 2017. 5-46 p.
  • Mariz IFA, Pinto S, Lavrado J, Paulo A, Martinho JMG, Maçôas EMS. Cryptolepine and quindoline: Understanding their photophysics. Physical Chemistry Chemical Physics. 2017;19(16):10255–63
  • Martins I, Varela A, Frija LMT, Estevão MAS, Planchon S, Renaut J, et al. Proteomic insights on the metabolism of Penicillium janczewskii during the biotransformation of the plant terpenoid labdanolic acid. Frontiers in Bioengineering and Biotechnology. 2017;5(AUG)
  • Matias D, Rijo P, Reis CP. Phytosomes as biocompatible carriers of natural drugs. Current Medicinal Chemistry. 2017;24(6):568–89
  • Miranda AS, Martelo LM, Fedorov AA, Berberan-Santos MN, Marcos PM. Fluorescence properties of: P-tert -butyldihomooxacalix[4]arene derivatives and the effect of anion complexation. New Journal of Chemistry. 2017;41(13):5967–73
  • Mónico A, Nim S, Duarte N, Rawal MK, Prasad R, Di Pietro A, et al. Lathyrol and epoxylathyrol derivatives: Modulation of Cdr1p and Mdr1p drug-efflux transporters of Candida albicans in Saccharomyces cerevisiae model. Bioorganic and Medicinal Chemistry. 2017;25(13):3278–84
  • Nunes RC, Ribeiro CJA, Monteiro Â, Rodrigues CMP, Amaral JD, Santos MMM. In vitro targeting of colon cancer cells using spiropyrazoline oxindoles. European Journal of Medicinal Chemistry. 2017;139:168–79
  • Paez A, Rojas HA, Portilla O, Sathicq G, Afonso CAM, Romanelli GP, et al. Preyssler Heteropolyacids in the Self-Etherification of 5-Hydroxymethylfurfural to 5,5-{[}Oxybis(methylene)]bis-2-furfural Under Mild Reaction Conditions. ChemCatChem. 2017;9(17):3322–9
  • Paterna A, Kincses A, Spengler G, Mulhovo S, Molnár J, Ferreira M-JU. Dregamine and tabernaemontanine derivatives as ABCB1 modulators on resistant cancer cells. European Journal of Medicinal Chemistry. 2017;128:247–57
  • Paulo A, Castillo C, Neidle S. Targeting Promoter Quadruplex Nucleic Acids for Cancer Therapy. In: Chackalamannil S, Rotella D, Ward S, editors. Comprehensive medicinal chemistry III. Amsterdam: Elsevier; 2017. p. 308–40.
  • Peixoto D, Figueiredo M, Gawande MB, Corvo MC, Vanhoenacker G, Afonso CAM, et al. Developments in the Reactivity of 2-Methylimidazolium Salts. Journal of Organic Chemistry. 2017;82(12):6232–41
  • Pereira E, Do Quental L, Palma E, Oliveira MC, Mendes F, Raposinho P, et al. Evaluation of Acridine Orange Derivatives as DNA-Targeted Radiopharmaceuticals for Auger Therapy: Influence of the Radionuclide and Distance to DNA. Scientific Reports. 2017;7
  • Pinheiro L, Faustino C. Amino Acid-Based Surfactants for Biomedical Applications. In: Reza Najjar, editor. Application and Characterization of Surfactants. London: InTech; 2017.
  • Pinheiro R, Braga C, Santos G, Bronze MR, Perry MJ, Moreira R, et al. Targeting Gliomas: Can a New Alkylating Hybrid Compound Make a Difference? ACS Chemical Neuroscience. 2017;8(1):50–9
  • Ravasco JMJM, Coelho JAS, Simeonov SP, Afonso CAM. Bifunctional Cr3+modified ion exchange resins as efficient reusable catalysts for the production and isolation of 5-hydroxymethylfurfural from glucose. RSC Advances. 2017;7(13):7555–9
  • Ravasco JMJM, Monteiro CM, Trindade AF. Cyclopropenes: A new tool for the study of biological systems. Organic Chemistry Frontiers. 2017;4(6):1167–98
  • Rebelo A, Molpeceres J, Rijo P, Reis CP. Pancreatic cancer therapy review: From classic therapeutic agents to modern nanotechnologies. Current Drug Metabolism. 2017;18(4):346–59
  • Reis MA, Ahmed OB, Spengler G, Molnár J, Lage H, Ferreira M-JU. Exploring Jolkinol D Derivatives to Overcome Multidrug Resistance in Cancer. Journal of Natural Products. 2017;80(5):1411–20
  • Restolho J, Barroso M, Saramago B, Dias M, Afonso CAM. Contactless decontamination of hair samples: cannabinoids. Drug Testing and Analysis. 2017;9(2):282–8
  • Restolho J, Barroso M, Saramago B, Dias M, Afonso CAM. Response to the letter to the editor Reply to Restolho et al. “Contactless decontamination of hair samples: cannabinoids” by Moosmann and Auwärter. Drug Testing and Analysis. 2017;9(2):290–2.
  • Ribeiro CJA, Nunes RC, Amaral JD, Gonçalves LM, Rodrigues CMP, Moreira R, et al. Spirotriazoline oxindoles: A novel chemical scaffold with in vitro anticancer properties. European Journal of Medicinal Chemistry. 2017;140:494–509
  • Ribeiro MHL. Emerging technologies of hydrogels in bioactive compounds delivery. In: Munish Puri, editor. Food Bioactives: Extraction and Biotechnology Applications. Cham: Springer International Publishing; 2017. 227-63 p.
  • Rocha Â, Teixeira R, Lourenço NMT, Afonso CAM. Enzymatic Kinetic Resolution of Secondary Alcohols Using an Ionic Anhydride Generated In Situ. ChemSusChem. 2017;10(1):296–302
  • Rodrigues CAB, Misale A, Schiel F, Maulide N. Direct synthesis of γ-pyrones by electrophilic condensation of β-ketoesters. Organic and Biomolecular Chemistry. 2017;15(3):680–3
  • Rodrigues PM, Afonso MB, Simaõ AL, Carvalho CC, Trindade A, Duarte A, et al. MiR-21 ablation and obeticholic acid ameliorate nonalcoholic steatohepatitis in mice. Cell Death and Disease. 2017;8(4)
  • Roque L, Molpeceres J, Reis C, Rijo P, Reis CP. Past, recent progresses and future perspectives of nanotechnology applied to antifungal agents. Current Drug Metabolism. 2017;18(4):280–90
  • Santos CAT, Páscoa RNMJ, Lopes JA. Applications of FTIR Spectroscopy in the Wine Industry. In: Moore E, editor. Fourier transform infrared spectroscopy (FTIR) : methods, analysis, and research insights. New York: Nova Science Publishers; 2017. p. 79–120.
  • Santos FMF, Matos AI, Ventura AE, Gonçalves J, Veiros LF, Florindo HF, et al. Modular Assembly of Reversible Multivalent Cancer-Cell-Targeting Drug Conjugates. Angewandte Chemie - International Edition. 2017;56(32):9346–50
  • Scapin E, Frizzo CP, Rodrigues LV, Zimmer GC, Vaucher RA, Sagrillo MR, et al. Synthesis, antimicrobial activity and cytotoxic investigation of novel trifluoromethylated tetrazolo[1,5-a]pyrimidines. Medicinal Chemistry Research. 2017;26(3):640–9
  • Simoes NG, Bettencourt AF, Monge N, Ribeiro IAC. Novel antibacterial agents: An emergent need to win the battle against infections. Mini-Reviews in Medicinal Chemistry. 2017;17(14):1364–76
  • Sintra TE, Nasirpour M, Siopa F, Rosatella AA, Gonçalves F, Coutinho JAP, et al. Ecotoxicological evaluation of magnetic ionic liquids. Ecotoxicology and Environmental Safety. 2017;143:315–21
  • Sitarek P, Rijo P, Garcia C, Skała E, Kalemba D, Białas AJ, et al. Antibacterial, Anti-Inflammatory, Antioxidant, and Antiproliferative Properties of Essential Oils from Hairy and Normal Roots of Leonurus sibiricus L. And Their Chemical Composition. Oxidative Medicine and Cellular Longevity. 2017;2017
  • Soares J, Espadinha M, Raimundo L, Ramos H, Gomes AS, Gomes S, et al. DIMP53-1: a novel small-molecule dual inhibitor of p53-MDM2/X interactions with multifunctional p53-dependent anticancer properties. Molecular Oncology. 2017 Jun;11(6):612–27
  • Soengas RG, Da Silva G, Estévez JC. Synthesis of spironucleosides: Past and future perspectives. Molecules. 2017;22(11)
  • Sousa A, Santos F, Gaspar MM, Calado S, Pereira JD, Mendes E, et al. The selective cytotoxicity of new triazene compounds to human melanoma cells. Bioorganic and Medicinal Chemistry. 2017;25(15):3900–10
  • Teixeira FA, Marcos PM, Ascenso JR, Brancatelli G, Hickey N, Geremia S. Selective Binding of Spherical and Linear Anions by Tetraphenyl(thio)urea-Based Dihomooxacalix[4]arene Receptors. Journal of Organic Chemistry. 2017;82(21):11383–90
  • Vicente AI, Coelho JAS, Simeonov SP, Lazarova HI, Popova MD, Afonso CAM. Oxidation of 5-Chloromethylfurfural (CMF) to 2,5-Diformylfuran (DFF). Molecules. 2017;22(2)
  • Vicente AI, Esteves T, Afonso CAM, Ferreira FC. Solvent compatible polymer functionalization with adenine, a DNA base, for API degenotoxification: Preparation and characterization. Separation and Purification Technology. 2017;179:438–48
  • Zomorodian A, Ribeiro IA, Fernandes JCS, Matos AC, Santos C, Bettencourt AF, et al. Biopolymeric coatings for delivery of antibiotic and controlled degradation of bioresorbable Mg AZ31 alloys. International Journal of Polymeric Materials and Polymeric Biomaterials. 2017;66(11):533–43
  • Zupancic E, Curato C, Paisana M, Rodrigues C, Porat Z, Viana AS, et al. Rational design of nanoparticles towards targeting antigen-presenting cells and improved T cell priming. Journal of Controlled Release. 2017 Jul;258:182–95.


Edifício H
Tel.: 217 946 400
Ext.: 14379
Correio eletrónico: mjuferreira@ff.ulisboa.pt