Pharmaceutical Chemistry and Therapeutics

Main Activities

Teaching of 1st, 2nd and 3rd cycles.
Scientific research and technological development.
University extension services:
            services to community
            outreach activities in the field of continuous education and the promotion of innovation.

Board

Head of Department
Maria José Umbelino Ferreira

Executive Committee
Carlos Alberto Mateus Afonso
Francisca Conceição Lopes
Maria José Umbelino Ferreira
Maria Henriques Lourenço Ribeiro
Rui Ferreira Alves Moreira

Department Committee
The Department Committee is constituted by DQFT Doctors linked to FFUL.

Research

R&D Units

Research Institute for Medicines (iMed.ULisboa)
            Research Groups:
            Medicinal Chemistry
            Bioorganic Chemistry
            Natural Products Chemistry
            Chemical Biology and Toxicology

Publications

2019

2018

2017

  • Andrade VM, Aschner M, Marreilha dos Santos AP. Neurotoxicity of Metal Mixtures. In: Michael AschnerLucio G. Costa, editor. Neurotoxicity of Metals. Cham: Springer; 2017. p. 227–65.
  • Anes E. Acting on Actin During Bacterial Infection. In: Jose C. Jimenez-Lopez, editor. Cytoskeleton - Structure, Dynamics, Function and Disease. London: InTech; 2017. p. 257–78.
  • Bettencourt P, Carmo N, Pires D, Timóteo P, Anes E. Mycobacterial infection of macrophages: the effect of the multiplicity of infection. In: Antimicrobial Research: Novel bioknowledge and educational programs. Badajóz: Formatex Research Center;
  • Gregorí Valdes BS, Vilela CCM, Ascenso A, Bordado JM RH. Topical formulations for onychomycosis: a review. In: Ascenso A, Ribeiro HM, Simões S, editors. Carrier-Mediated Dermal Delivery: Applications in the Prevention and Treatment of Skin Disorders. Singapore: Pan Stanford; 2017. p. 503–53.
  • Ismaili L, Romero A, Carreiras MC, Marco-Contelles J. Multitarget-Directed Antioxidants as Therapeutic Agents. In: Michael Decker, editor. Design of Hybrid Molecules for Drug Development. Amsterdam: Elsevier; 2017. p. 5–46.
  • Lambricht L, Peres C, Florindo H, Préat V, Vandermeulen G. Polymer-Based Nanoparticles as Modern Vaccine Delivery Systems. In: Skwarczynski M, Toth I, editors. Micro and Nanotechnology in Vaccine Development. Oxford: William Andrew Publishing; 2017. p. 185–203.
  • Lana J, Ascenso A. New Trends in Anti-Aging Skin Care. In: Ascenso A, Ribeiro HM, Simões S, editors. Carrier-Mediated Dermal Delivery: Applications in the Prevention and Treatment of Skin Disorders. Singapore: Pan Stanford; 2017. p. 3–41.
  • Malmir M, Serrano R, Silva O. Anthraquinones as potential antimicrobial agents-A review. In: A. Méndez-Vilas, editor. Antimicrobial research: Novel bioknowledge and educational programs. Badajoz: Formatex Research Center; 2017. p. 55-61.
  • Manteigas P, Ascenso A. Melatonin: a “guardian” of the genome and cellular integrity for prevention of photocarcinogenesis. In: Ascenso A, Ribeiro HM, Simões S, editors. Carrier-Mediated Dermal Delivery: Applications in the Prevention and Treatment of Skin Disorders. Singapore: Pan Stanford; 2017. p. 43–90.
  • Marto J, Jorge I, Almeida A, Ribeiro H. Novel starch-derived topical delivery systems. In: Ascenso A, Ribeiro H, Simões S, editors. Carrier-Mediated Dermal Delivery: Applications in the Prevention and Treatment of Skin Disorders. Singapore: Pan Stanford; 2017. p. 175–216.
  • Mendes T, Gaspar M, Simões S, Ascenso A. Lipid Vesicles for Skin Delivery: Evolution from first generation. In: Ascenso A, Ribeiro HM, Simões S, editors. Carrier-Mediated Dermal Delivery: Applications in the Prevention and Treatment of Skin Disorders. Singapore: Pan Stanford; 2017. p. 281–321.
  • Nunes A, Ramalho R, Rodrigues CMP. Morte celular no sistema nervoso. In: Rego AC, Duarte CB, Oliveira CR, editors. Neurociências. Lisboa: Lidel; 2017. p. 499–512.
  • Paulo A, Castillo C, Neidle S. Targeting Promoter Quadruplex Nucleic Acids for Cancer Therapy. In: Chackalamannil S, Rotella D, Ward S, editors. Comprehensive medicinal chemistry III. Amsterdam: Elsevier; 2017. p. 308–40.
  • Pinheiro L, Faustino C. Amino Acid-Based Surfactants for Biomedical Applications. In: Reza Najjar, editor. Application and Characterization of Surfactants. London: InTech; 2017.
  • Pires C, Cavaco A, Vigario M. How sociodemographic features impact subjects’ opinion on packages leaflets of medicines? Australasian Medical Journal. 2017;10(9):774–84
  • Pires C, Cavaco A, Vigário M. Towards the Definition of Linguistic Metrics for Evaluating Text Readability. Journal of Quantitative Linguistics. 2017;24(4):319–49
  • Pires C, Martins F, Cavaco A, Vigário M. Automatic quantification of abbreviations in medicine package leaflets and their comprehension assessment. International Journal of E-Health and Medical Communications. 2017;8(2):47–64
  • Pires C, Vigário M, Cavaco A. Evaluation of the type and structure of the imprints used on the surface of medicines. Journal of Pharmacy Practice and Research. 2017;47(1):23–6
  • Pires D, Bernard EM, Pombo JP, Carmo N, Fialho C, Gutierrez MG, et al. Mycobacterium tuberculosis modulates miR-106b-5p to control Cathepsin S expression resulting in higher pathogen survival and poor T-cell activation. Frontiers in Immunology. 2017;8(DEC)
  • Polsinelli B, Tsigkos S, Naumann-Winter F, Mariz S, Sepodes B. Evolving prevalence of haematological malignancies in orphan designation procedures in the European Union. Orphanet Journal of Rare Diseases. 2017;12(1)
  • Pontes da Costa A, Nunes DR, Tharaud M, Oble J, Poli G, Rieger J. Palladium(0) Nanoparticles Embedded in Core–shell Nanogels as Recoverable Catalysts for the Mizoroki–Heck Reaction. ChemCatChem. 2017;9(12):2167–75
  • Raaf N, Amhis W, Saoula H, Abid A, Nakmouche M, Balamane A, et al. Prevalence, antibiotic resistance, and MLST typing of Helicobacter pylori in Algiers, Algeria. Helicobacter. 2017;22(6)
  • Raposo LR, Roma-Rodrigues C, Faísca P, Alves M, Henriques J, Carvalheiro MC, et al. Immortalization and characterization of a new canine mammary tumour cell line FR37-CMT. Veterinary and Comparative Oncology. 2017;15(3):952–67
  • Ravasco JMJM, Coelho JAS, Simeonov SP, Afonso CAM. Bifunctional Cr3+modified ion exchange resins as efficient reusable catalysts for the production and isolation of 5-hydroxymethylfurfural from glucose. RSC Advances. 2017;7(13):7555–9
  • Ravasco JMJM, Monteiro CM, Trindade AF. Cyclopropenes: A new tool for the study of biological systems. Organic Chemistry Frontiers. 2017;4(6):1167–98
  • Rebelo A, Molpeceres J, Rijo P, Reis CP. Pancreatic cancer therapy review: From classic therapeutic agents to modern nanotechnologies. Current Drug Metabolism. 2017;18(4):346–59
  • Reis C, Antunes AF, Pereira P, Reis C, Rijo P. Nanosystems for skin delivery: From drugs to cosmetics. Current Drug Metabolism. 2017;18(5):412–25
  • Reis CP, Neufeld RJ, Veiga F, Ribeiro AJ, Neufeld RJ, Veiga F, et al. Preparation of Drug-Loaded Polymeric Nanoparticles. In: Lajos P Balogh, editor. Nanomedicine in Cancer. Singapore: Pan Stanford; 2017. p. 171–214.
  • Reis MA, Ahmed OB, Spengler G, Molnár J, Lage H, Ferreira M-JU. Exploring Jolkinol D Derivatives to Overcome Multidrug Resistance in Cancer. Journal of Natural Products. 2017;80(5):1411–20
  • Reis WC, Bonetti AF, Bottacin WE, Reis AS, Souza TT, Pontarolo R, et al. Impact on process results of clinical decision support systems (CDSSS) applied to medication use: Overview of systematic reviews. Pharmacy Practice. 2017;15(4)
  • Reis-Pardal J, Rodrigues A, Rodrigues E, Fernandez-Llimos F. Comparing cytochrome P450 pharmacogenetic information available on United States drug labels and European Union Summaries of Product Characteristics. Pharmacogenomics Journal. 2017;17(6):488–93
  • Ren X, Zou L, Zhang X, Branco V, Wang J, Carvalho C, et al. Redox Signaling Mediated by Thioredoxin and Glutathione Systems in the Central Nervous System. Antioxidants and Redox Signaling. 2017;27(13):989–1010
  • Resende AP, Silva B, Braz BS, Nunes T, Gonçalves L, Delgado E. Ex vivo permeation of erythropoietin through porcine conjunctiva, cornea, and sclera. Drug Delivery and Translational Research. 2017;7(5):625–31
  • Restolho J, Barroso M, Saramago B, Dias M, Afonso CAM. Contactless decontamination of hair samples: cannabinoids. Drug Testing and Analysis. 2017;9(2):282–8
  • Rezayan AH, Hariri S, Azerang P, Ghavami G, Portugal I, Sardari S. Synthesis of novel fluorene bisamide derivatives via ugi reaction and evaluation their biological activity against Mycobacterium species. Iranian Journal of Pharmaceutical Research. 2017;16(2):724–52
  • Ribeiro CJA, Nunes RC, Amaral JD, Gonçalves LM, Rodrigues CMP, Moreira R, et al. Spirotriazoline oxindoles: A novel chemical scaffold with in vitro anticancer properties. European Journal of Medicinal Chemistry. 2017;140:494–509
  • Rocha C, Duarte J, Borrego P, Calado R, Marcelino JM, Tendeiro R, et al. Potency of HIV-2-specific antibodies increase in direct association with loss of memory B cells. AIDS. 2017;31(17):2431–3
  • Rocha Â, Teixeira R, Lourenço NMT, Afonso CAM. Enzymatic Kinetic Resolution of Secondary Alcohols Using an Ionic Anhydride Generated In Situ. ChemSusChem. 2017;10(1):296–302
  • Rodrigues C, Novais Â, Sousa C, Ramos H, Coque TM, Cantón R, et al. Elucidating constraints for differentiation of major human Klebsiella pneumoniae clones using MALDI-TOF MS. European Journal of Clinical Microbiology and Infectious Diseases. 2017;36(2):379–86
  • Rodrigues C, Tartaro Bujak I, Mihaljević B, Soveral G, Cipak Gasparovic A. Yeast aquaporin regulation by 4-hydroxynonenal is implicated in oxidative stress response. IUBMB Life. 2017;69(5):355–62
  • Rodrigues CAB, Misale A, Schiel F, Maulide N. Direct synthesis of γ-pyrones by electrophilic condensation of β-ketoesters. Organic and Biomolecular Chemistry. 2017;15(3):680–3
  • Rodrigues LM, Palma L, Santos O, Almeida MA, Bujan J, Tavares L. Excessive Weight Favours Skin Physiology - Up to a Point: Another Expression of the Obesity Paradox. Skin Pharmacology and Physiology. 2017;30(2):94–101
  • Rodrigues PM, Afonso MB, Simaõ AL, Carvalho CC, Trindade A, Duarte A, et al. MiR-21 ablation and obeticholic acid ameliorate nonalcoholic steatohepatitis in mice. Cell Death and Disease. 2017;8(4)
  • Rolim I, Duarte N, Barata G, Costa J, Gardete-Correia L, Boavida J, et al. Immunoglobulin M gene association with autoantibody reactivity and type 1 diabetes. Immunogenetics. 2017;69(7):429–37
  • Romero-Severson EO, Bulla I, Hengartner N, Bartolo I, Abecasis A, Azevedo-Pereira JM, et al. Donor-Recipient Identification in Para- and Poly-phyletic Trees Under Alternative HIV-1 Transmission Hypotheses Using Approximate Bayesian Computation. Genetics. 2017 Nov;207(3):1089–101
  • Roque L, Molpeceres J, Reis C, Rijo P, Reis CP. Past, recent progresses and future perspectives of nanotechnology applied to antifungal agents. Current Drug Metabolism. 2017;18(4):280–90
  • Roque LV, Dias IS, Cruz N, Rebelo A, Roberto A, Rijo P, et al. Design of Finasteride-Loaded Nanoparticles for Potential Treatment of Alopecia. Skin Pharmacology and Physiology. 2017;30(4):197–204
  • Rosa AI, Fonseca I, Nunes MJ, Moreira S, Rodrigues E, Carvalho AN, et al. Novel insights into the antioxidant role of tauroursodeoxycholic acid in experimental models of Parkinson’s disease. Biochimica et Biophysica Acta - Molecular Basis of Disease. 2017;1863(9):2171–81
  • Rosado C, Antunes F, Barbosa R, Fernando R, Estudante M, Silva HN, et al. About the in vivo quantitation of skin anisotropy. Skin Research and Technology. 2017;23(3):429–36
  • Rotta I, Souza TT, Salgado TM, Correr CJ, Fernandez-Llimos F. Characterization of published randomized controlled trials assessing clinical pharmacy services around the world. Research In Social & Administrative Pharmacy. 2017;13(1):201–8
  • Saldanha Do Carmo C, Maia C, Poejo J, Lychko I, Gamito P, Nogueira I, et al. Microencapsulation of α-tocopherol with zein and β-cyclodextrin using spray drying for colour stability and shelf-life improvement of fruit beverages. RSC Advances. 2017;7(51):32065–75
  • Santos CAT, Páscoa RNMJ, Lopes JA. Applications of FTIR Spectroscopy in the Wine Industry. In: Moore E, editor. Fourier transform infrared spectroscopy (FTIR) : methods, analysis, and research insights. New York: Nova Science Publishers; 2017. p. 79–120.
  • Santos DM, Aschner M, Santos APM. Manganese and Neurodegeneration. In: Anthony R. White MA, Lucio G. Costa, Ashley I. Bush, editors. Biometals in Neurodegenerative Diseases. London: Academic Press; 2017. p. 117–51.
  • Santos FMF, Matos AI, Ventura AE, Gonçalves J, Veiros LF, Florindo HF, et al. Modular Assembly of Reversible Multivalent Cancer-Cell-Targeting Drug Conjugates. Angewandte Chemie - International Edition. 2017;56(32):9346–50
  • Santos T, Ferreira R, Quartin E, Boto C, Saraiva C, Bragança J, et al. Blue light potentiates neurogenesis induced by retinoic acid-loaded responsive nanoparticles. Acta Biomaterialia. 2017;59:293–302
  • Scapin E, Frizzo CP, Rodrigues LV, Zimmer GC, Vaucher RA, Sagrillo MR, et al. Synthesis, antimicrobial activity and cytotoxic investigation of novel trifluoromethylated tetrazolo[1,5-a]pyrimidines. Medicinal Chemistry Research. 2017;26(3):640–9
  • Scomparin A, Florindo HF, Tiram G, Ferguson EL, Satchi-Fainaro R. Two-step polymer- and liposome-enzyme prodrug therapies for cancer: PDEPT and PELT concepts and future perspectives. Advanced Drug Delivery Reviews. 2017;118:52–64
  • Shamsabadi A, Ren J, Chudasama V. Enabling the facile conversion of acyl hydrazides into: N -acyl carbamates via metal-free ionic-based rupture of the N-N linkage. RSC Advances. 2017;7(44):27608–11
  • Silva AF, Sarraguça MC, Fonteyne M, Vercruysse J, De Leersnyder F, Vanhoorne V, et al. Multivariate statistical process control of a continuous pharmaceutical twin-screw granulation and fluid bed drying process. International Journal of Pharmaceutics. 2017;528(1–2):242–52
  • Silva AFT, Sarraguça MC, Ribeiro PR, Santos AO, De Beer T, Lopes JA. Statistical process control of cocrystallization processes: A comparison between OPLS and PLS. International Journal of Pharmaceutics. 2017;520(1–2):29–38
  • Silva AL, Peres C, Conniot J, Matos AI, Moura L, Carreira B, et al. Nanoparticle impact on innate immune cell pattern-recognition receptors and inflammasomes activation. Seminars In Immunology. 2017;34(C):3–24
  • Silva AS, Quintelas C, Ferreira EC, Lopes JA, Sousa C. Exploiting intrinsic fluorescence spectroscopy to discriminate between Acinetobacter calcoaceticus-Acinetobacter baumannii complex species. RSC Advances. 2017;7(14):8581–8
  • Silva B, Nunes A, Vale FF, Rocha R, Gomes JP, Dias R, et al. The expression of Helicobacter pylori tfs plasticity zone cluster is regulated by pH and adherence, and its composition is associated with differential gastric IL-8 secretion. Helicobacter. 2017;22(4)
  • Silva FC, Marto JM, Salgado A, Machado P, Silva AN, Almeida AJ. Nystatin and lidocaine pastilles for the local treatment of oral mucositis. Pharmaceutical Development and Technology. 2017;22(2):266–74
  • Silva LJG, Pereira AMPT, Rodrigues H, Meisel LM, Lino CM, Pena A. SSRIs antidepressants in marine mussels from Atlantic coastal areas and human risk assessment. Science of the Total Environment. 2017;603–604:118–25
  • Silva MM, Calado R, Marto J, Bettencourt A, Almeida AJ, Gonçalves LMD. Chitosan nanoparticles as a mucoadhesive drug delivery system for ocular administration. Marine Drugs. 2017;15(12)
  • Silva O, Serrano R. Micromorphological studies for application in the quality control of herbal medicines-some data of plants used in Mozambique. In: Méndez-Vilas A, editor. Microscopy and imaging science: practical approaches to applied research and education. Badajoz: Formatex Research Center; 2017. p. 231–6.
  • Silva T, Grenho L, Barros J, Silva JC, Pinto RV, Matos A, et al. A minocycline-releasing PMMA system as a space maintainer for staged bone reconstructions-in vitro antibacterial, cytocompatibility and anti-inflammatory characterization. Biomedical Materials (Bristol). 2017;12(3)
  • Simoes MG, Alves P, Carvalheiro M, Simoes PN. Stability effect of cholesterol-poly(acrylic acid) in a stimuli-responsive polymer-liposome complex obtained from soybean lecithin for controlled drug delivery. Colloids and Surfaces B-Biointerfaces. 2017;152:103–13
  • Simoes NG, Bettencourt AF, Monge N, Ribeiro IAC. Novel antibacterial agents: An emergent need to win the battle against infections. Mini-Reviews in Medicinal Chemistry. 2017;17(14):1364–76
  • Simões S, Carvalheiro M, Gaspar M. Lipid-based nanocarriers for the treatment of infected skin lesions. In: Ascenso A, Ribeiro HM, Simões S, editors. Carrier-Mediated Dermal Delivery: Applications in the Prevention and Treatment of Skin Disorders. Singapore: Pan Stanford; 2017. p. 387–430.
  • Sintra TE, Nasirpour M, Siopa F, Rosatella AA, Gonçalves F, Coutinho JAP, et al. Ecotoxicological evaluation of magnetic ionic liquids. Ecotoxicology and Environmental Safety. 2017;143:315–21
  • Sitarek P, Rijo P, Garcia C, Skała E, Kalemba D, Białas AJ, et al. Antibacterial, Anti-Inflammatory, Antioxidant, and Antiproliferative Properties of Essential Oils from Hairy and Normal Roots of Leonurus sibiricus L. And Their Chemical Composition. Oxidative Medicine and Cellular Longevity. 2017;2017
  • Smith D, Hornstra J, Rocha M, Jansen G, Assaraf Y, Lasry I, et al. Folic Acid Impairs the Uptake of 5-Methyltetrahydrofolate in Human Umbilical Vascular Endothelial Cells. Journal of Cardiovascular Pharmacology. 2017;70(4):271–5
  • Soares J, Espadinha M, Raimundo L, Ramos H, Gomes AS, Gomes S, et al. DIMP53-1: a novel small-molecule dual inhibitor of p53-MDM2/X interactions with multifunctional p53-dependent anticancer properties. Molecular Oncology. 2017 Jun;11(6):612–27
  • Soengas RG, Da Silva G, Estévez JC. Synthesis of spironucleosides: Past and future perspectives. Molecules. 2017;22(11)
  • Sousa A, Santos F, Gaspar MM, Calado S, Pereira JD, Mendes E, et al. The selective cytotoxicity of new triazene compounds to human melanoma cells. Bioorganic and Medicinal Chemistry. 2017;25(15):3900–10
  • Soveral G, Casini A. Aquaporin modulators: a patent review (2010–2015). Expert Opinion on Therapeutic Patents. 2017;27(1):49–62
  • Steimbach LM, Tonin FS, Virtuoso S, Souza AW, Fernandez-Llimos F, Pontarolo R. Nephrotoxicity of amphotericin-B lipid-based formulations versus conventional one: A systematic review and meta-analysis. International Journal of Clinical Pharmacy. 2017;39(1):325–6
  • Stewart D, Gibson-Smith K, MacLure K, Mair A, Alonso A, Codina C, et al. A modified Delphi study to determine the level of consensus across the European Union on the structures, processes and desired outcomes of the management of polypharmacy in older people. PLoS ONE. 2017;12(11)
  • Subtil J, Rodrigues JC, Reis L, Freitas L, Filipe J, Santos A, et al. Adenoid bacterial colonization in a paediatric population. European Archives of Oto-Rhino-Laryngology. 2017;274(4):1933–8
  • Teixeira dos Santos CA, Páscoa RNMJ, Sarraguça MC, Porto PALS, Cerdeira AL, González-Sáiz JM, et al. Merging vibrational spectroscopic data for wine classification according to the geographic origin. Food Research International. 2017;102:504–10
  • Teixeira FA, Marcos PM, Ascenso JR, Brancatelli G, Hickey N, Geremia S. Selective Binding of Spherical and Linear Anions by Tetraphenyl(thio)urea-Based Dihomooxacalix[4]arene Receptors. Journal of Organic Chemistry. 2017;82(21):11383–90
  • Tenreiro MM, Correia ML, Brito MA. Endothelial progenitor cells in multiple myeloma neovascularization: a brick to the wall. Angiogenesis. 2017;20(4):443–62
  • Thorell K, Lehours P, Vale FF. Genomics of Helicobacter pylori. Helicobacter. 2017;22
  • Tonin FS, Steimbach LM, Borba HH, Sanches AC, Wiens A, Pontarolo R, et al. Efficacy and safety of amphotericin B formulations: a network meta-analysis and a multicriteria decision analysis. Journal of Pharmacy and Pharmacology. 2017;69(12):1672–83
  • Vale FF, Nunes A, Oleastro M, Gomes JP, Sampaio DA, Rocha R, et al. Genomic structure and insertion sites of Helicobacter pylori prophages from various geographical origins. Scientific Reports. 2017;7
  • Varela ARP, Ventura AE, Carreira AC, Fedorov A, Futerman AH, Prieto M, et al. Pathological levels of glucosylceramide change the biophysical properties of artificial and cell membranes†. Physical Chemistry Chemical Physics. 2017;19(1):340–6
  • Vicente AI, Coelho JAS, Simeonov SP, Lazarova HI, Popova MD, Afonso CAM. Oxidation of 5-Chloromethylfurfural (CMF) to 2,5-Diformylfuran (DFF). Molecules. 2017;22(2)
  • Vicente AI, Esteves T, Afonso CAM, Ferreira FC. Solvent compatible polymer functionalization with adenine, a DNA base, for API degenotoxification: Preparation and characterization. Separation and Purification Technology. 2017;179:438–48
  • Vicente JB, Colaço HG, Malagrinò F, Santo PE, Gutierres A, Bandeiras TM, et al. A Clinically Relevant Variant of the Human Hydrogen Sulfide-Synthesizing Enzyme Cystathionine β -Synthase: Increased CO Reactivity as a Novel Molecular Mechanism of Pathogenicity? Oxidative Medicine and Cellular Longevity. 2017;2017
  • Viegas C, Faria T, Caetano LA, Carolino E, Gomes AQ, Viegas S. Aspergillus spp. prevalence in different Portuguese occupational environments: What is the real scenario in high load settings? Journal of Occupational and Environmental Hygiene. 2017;14(10):771–85
  • Viegas C, Faria T, de Oliveira AC, Caetano LA, Carolino E, Quintal-Gomes A, et al. A new approach to assess occupational exposure to airborne fungal contamination and mycotoxins of forklift drivers in waste sorting facilities. Mycotoxin Research. 2017;33(4):285–95
  • Viegas C, Pacífico C, Faria T, de Oliveira AC, Caetano LA, Carolino E, et al. Fungal contamination in green coffee beans samples: A public health concern. Journal of Toxicology and Environmental Health - Part A: Current Issues. 2017;80(13–15):719–28
  • Viegas S, Caetano LA, Korkalainen M, Faria T, Pacífico C, Carolino E, et al. Cytotoxic and inflammatory potential of air samples from occupational settings with exposure to organic dust. Toxics. 2017;5(1)
  • Vitorino C, Almeida AJ. Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) as topical delivery systems for antioxidants. In: Ascenso A, Ribeiro HM, Simões S, editors. Carrier-Mediated Dermal Delivery: Applications in the Prevention and Treatment of Skin Disorders. Singapore: Pan Stanford; 2017. p. 217–63.
  • Vos T, Abajobir AA, Abbafati C, Abbas KM, Abate KH, Abd-Allah F, et al. Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990-2016: A systematic analysis for the Global Burden of Disease Study 2016. The Lancet. 2017;390(10100):1211–59
  • Wang H, Abajobir AA, Abate KH, Abbafati C, Abbas KM, Abd-Allah F, et al. Global, regional, and national under-5 mortality, adult mortality, age-specific mortality, and life expectancy, 1970-2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet. 2017;390(10100):1084–150
  • Xiong S, Borrego P, Ding X, Zhu Y, Martins A, Chong H, et al. A helical short-peptide fusion inhibitor with highly potent activity against human immunodeficiency virus type 1 (HIV-1), HIV-2, and simian immunodeficiency virus. Journal of Virology. 2017;91(1)
  • Zomorodian A, Ribeiro IA, Fernandes JCS, Matos AC, Santos C, Bettencourt AF, et al. Biopolymeric coatings for delivery of antibiotic and controlled degradation of bioresorbable Mg AZ31 alloys. International Journal of Polymeric Materials and Polymeric Biomaterials. 2017;66(11):533–43

2016

  • Afonso MB, Rodrigues PM, Simão AL, Ofengeim D, Carvalho T, Amaral JD, et al. Activation of necroptosis in human and experimental cholestasis. Cell Death and Disease. 2016;7(9).
  • Almeida A, Martins AP, Mosca AF, Wijma HJ, Prista C, Soveral G, et al. Exploring the gating mechanisms of aquaporin-3: new clues for the design of inhibitors? Molecular Biosystems. 2016;12(5):1564–73.
  • Araújo O, Lage I, Cabrita J, Teixeira L. Development and psychometric properties of ECPICID-AVC to measure informal caregivers’ skills when caring for older stroke survivors at home. Scandinavian Journal of Caring Sciences. 2016;30(4):821–9.
  • Arranja A, Gouveia LF, Gener P, Rafael DF, Pereira C, Schwartz Jr. S, et al. Self-assembly PEGylation assists SLN-paclitaxel delivery inducing cancer cell apoptosis upon internalization. International Journal of Pharmaceutics. 2016 Mar;501(1–2):180–9.
  • Ascenso A, Pedrosa T, Pinho S, Pinho F, De Oliveira JMPF, Marques HC, et al. The Effect of Lycopene Preexposure on UV-B-Irradiated Human Keratinocytes. Oxidative Medicine and Cellular Longevity. 2016;2016.
  • Barateiro A, Mahu I, Domingos AI. Leptin Resistance and the Neuro-Adipose Connection. Frontiers In Endocrinology. 2016 Mar;8.
  • Berthenet E, Sheppard S, Vale FF. Recent “omics” advances in Helicobacter pylori. Helicobacter. 2016;21:14–8.
  • Bonito CA, Nunes J, Leandro J, Louro F, Leandro P, Ventura FV, et al. Unveiling the Pathogenic Molecular Mechanisms of the Most Common Variant (p.K329E) in Medium-Chain Acyl-CoA Dehydrogenase Deficiency by in Vitro and in Silico Approaches. Biochemistry. 2016;55(51):7086–98.
  • Caetano LA, Almeida AJ, Gonçalves LMD. Effect of experimental parameters on alginate/chitosan microparticles for BCG encapsulation. Marine Drugs. 2016;14(5).
  • Carbas B, Vaz-Patto MC, Bronze MR, Bento-Da-Silva A, Trigo MJ, Brites C. Maize flour parameters that are related to the consumer perceived quality of ‘broa’ specialty bread. Food Science and Technology. 2016;36(2):259–67.
  • Cardoso A, Almeida C, Cordeiro T, Gaffney V. Disinfectants: Properties, Applications and Effectiveness. New York: Nova Science Publishers; 2016.
  • Carmo C, Nunes AN, Silva I, Maia C, Poejo J, Ferreira-Dias S, et al. Formulation of pea protein for increased satiety and improved foaming properties. RSC Advances. 2016;6(8):6048–57.
  • Cláudio AP, Carmo MB, Guerreiro MP, Cavaco A, Pinto V, Pinha A. Virtual Humans playing the role of patients in self-medication consultations: Perspectives of undergraduate pharmacy students. In: VISIGRAPP 2016 - Proceedings of the 11th Joint Conference on Computer Vision, Imaging and Computer Graphics Theory and Applications. 2016. p. 298–305.
  • Costa J, Matos A, Bettencourt A, Portugal J, Neves CB. Effect of ethanol solutions as post-polymerization treatment on the properties of acrylic reline resins | Efeito do tratamento pós-polimerização com soluções de etanol nas propriedades de resinas de rebasamento. Revista Portuguesa de Estomatologia, Medicina Dentaria e Cirurgia Maxilofacial. 2016;57(4):215–22.
  • Costa JG, Saraiva N, Guerreiro PS, Louro H, Silva MJ, Miranda JP, et al. Ochratoxin A-induced cytotoxicity, genotoxicity and reactive oxygen species in kidney cells: An integrative approach of complementary endpoints. Food and Chemical Toxicology. 2016;87:65–76.
  • Cunha C, Gomes C, Vaz AR, Brites D. Exploring New Inflammatory Biomarkers and Pathways during LPS-Induced M1 Polarization. Mediators of Inflammation. 2016;2016.
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