Microbiologia e Imunologia

Principais Atividades

Ensino de 1.º, 2.º e 3.º ciclos.
Investigação científica e desenvolvimento tecnológico.
Serviços de extensão universitária:
            serviços ao exterior
            atividades complementares no domínio da formação contínua e da promoção da inovação.

Órgãos

Presidente
João Manuel Braz Gonçalves

Comissão de Departamento
A Comissão de Departamento é constituída pelos Doutores do DMI com vínculo à FFUL.

Regulamento

Investigação

Instituto de Investigação do Medicamento (iMed.ULisboa)
           
Grupos de Investigação:
            Microbiologia Molecular e Biotecnologia
            Interações Hospedeiro Patogeno
            Evolução, Epidemiologia e Prevenção da Infeção por HIV

2017

ReferênciaTipo de Documento
Bettencourt P, Carmo N, Pires D, Timóteo P, Anes E. Mycobacterial infection of macrophages: the effect of the multiplicity of infection. In: Antimicrobial Research: Novel bioknowledge and educational programs. Badajóz: Formatex Research Center;

Livros e Capítulos de Livros

Xiong S, Borrego P, Ding X, Zhu Y, Martins A, Chong H, et al. A helical short-peptide fusion inhibitor with highly potent activity against human immunodeficiency virus type 1 (HIV-1), HIV-2, and simian immunodeficiency virus. Journal of Virology. 2017;91(1)

Artigos

Wang H, Abajobir AA, Abate KH, Abbafati C, Abbas KM, Abd-Allah F, et al. Global, regional, and national under-5 mortality, adult mortality, age-specific mortality, and life expectancy, 1970-2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet. 2017;390(10100):1084–150

Artigos

Vos T, Abajobir AA, Abbafati C, Abbas KM, Abate KH, Abd-Allah F, et al. Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990-2016: A systematic analysis for the Global Burden of Disease Study 2016. The Lancet. 2017;390(10100):1211–59

Artigos

Subtil J, Rodrigues JC, Reis L, Freitas L, Filipe J, Santos A, et al. Adenoid bacterial colonization in a paediatric population. European Archives of Oto-Rhino-Laryngology. 2017;274(4):1933–8

Artigos

Santos FMF, Matos AI, Ventura AE, Gonçalves J, Veiros LF, Florindo HF, et al. Modular Assembly of Reversible Multivalent Cancer-Cell-Targeting Drug Conjugates. Angewandte Chemie - International Edition. 2017;56(32):9346–50

Artigos

Romero-Severson EO, Bulla I, Hengartner N, Bartolo I, Abecasis A, Azevedo-Pereira JM, et al. Donor-Recipient Identification in Para- and Poly-phyletic Trees Under Alternative HIV-1 Transmission Hypotheses Using Approximate Bayesian Computation. Genetics. 2017 Nov;207(3):1089–101

Artigos

Rolim I, Duarte N, Barata G, Costa J, Gardete-Correia L, Boavida J, et al. Immunoglobulin M gene association with autoantibody reactivity and type 1 diabetes. Immunogenetics. 2017;69(7):429–37

Artigos

Rocha C, Duarte J, Borrego P, Calado R, Marcelino JM, Tendeiro R, et al. Potency of HIV-2-specific antibodies increase in direct association with loss of memory B cells. AIDS. 2017;31(17):2431–3

Artigos

Rezayan AH, Hariri S, Azerang P, Ghavami G, Portugal I, Sardari S. Synthesis of novel fluorene bisamide derivatives via ugi reaction and evaluation their biological activity against Mycobacterium species. Iranian Journal of Pharmaceutical Research. 2017;16(2):724–52

Artigos

Pires D, Bernard EM, Pombo JP, Carmo N, Fialho C, Gutierrez MG, et al. Mycobacterium tuberculosis modulates miR-106b-5p to control Cathepsin S expression resulting in higher pathogen survival and poor T-cell activation. Frontiers in Immunology. 2017;8(DEC)

Artigos

Piedade D, Azevedo-Pereira JM. MicroRNAs as important players in host-adenovirus interactions. Frontiers in Microbiology. 2017;8(JUL)

Artigos

Perdigão J, Clemente S, Ramos J, Masakidi P, Machado D, Silva C, et al. Genetic diversity, transmission dynamics and drug resistance of Mycobacterium tuberculosis in Angola. Scientific Reports. 2017;7

Artigos

Penazzato M, Palladino C, Sugandhi N. Prioritizing the most needed formulations to accelerate paediatric antiretroviral therapy scale-up. Current Opinion in HIV and AIDS. 2017;12(4):369–76

Artigos

Palladino C, Sánchez-Carrillo M, Mate-Cano I, Vázquez-Morón S, Jimenez-Sousa MÁ, Gutiérrez-Rivas M, et al. Low frequency of NS5A relevant resistance-associated substitutions to Elbasvir among hepatitis C virus genotype 1a in Spain: A cross-sectional study. Scientific Reports. 2017;7(1)

Artigos

Neves A, Marto J, Duarte A, Goncalves LM, Pinto P, Figueiredo AC, et al. Characterization of Portuguese Thymbra capitata, Thymus caespititius and Myrtus communis essential oils in topical formulations. Flavour and Fragrance Journal. 2017;32(5):392–402

Artigos

Nakatani Y, Opel-Reading HK, Merker M, Machado D, Andres S, Kumar SS, et al. Role of alanine racemase mutations in Mycobacterium tuberculosis D-cycloserine resistance. Antimicrobial Agents and Chemotherapy. 2017;61(12)

Artigos

Naghavi M, Abajobir AA, Abbafati C, Abbas KM, Abd-Allah F, Abera SF, et al. Global, regional, and national age-sex specifc mortality for 264 causes of death, 1980-2016: A systematic analysis for the Global Burden of Disease Study 2016. The Lancet. 2017;390(10100):1151–210

Artigos

Martin F, Palladino C, Mateus R, Bolzan A, Gomes P, Brito J, et al. Early infant diagnosis of HIV-1 infection in Luanda, Angola, using a new DNA PCR assay and dried blood spots. PLoS ONE. 2017;12(7)

Artigos

Maltez F, Martins T, Póvoas D, Cabo J, Peres H, Antunes F, et al. Multidrug-resistant tuberculosis by strains of beijing family, in patients from Lisbon, Portugal: Preliminary report | Tuberculose multirresistente por estirpes da família beijing, em doentes de Lisboa, Portugal: Estudo preliminar. Acta Medica Portuguesa. 2017;30(3):175–84

Artigos

Machado D, Coelho TS, Perdigão J, Pereira C, Couto I, Portugal I, et al. Interplay between mutations and efflux in drug resistant clinical isolates of Mycobacterium tuberculosis. Frontiers in Microbiology. 2017;8(APR)

Artigos

Goncalves J, Matos de Brito P, Batista A, Feio J, Machado F, Aperta J, et al. Position Paper from the Portuguese Association of Hospital Pharmacists for biosimilar therapeutic antibodies. Journal of Clinical Pharmacy and Therapeutics. 2017;42(2):239–43.

Artigos

Gouveia Z, Carlos AR, Yuan X, Aires-da-Silva F, Stocker R, Maghzal GJ, et al. Characterization of plasma labile heme in hemolytic conditions. FEBS Journal. 2017;284(19):3278–301.

Artigos

Gubareva LV, Besselaar TG, Daniels RS, Fry A, Gregory V, Huang W, et al. Global update on the susceptibility of human influenza viruses to neuraminidase inhibitors, 2015–2016. Antiviral Research. 2017;146:12–20.

Artigos

Hay SI, Abajobir AA, Abate KH, Abbafati C, Abbas KM, Abd-Allah F, et al. Global, regional, and national disability-adjusted life-years (DALYs) for 333 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet. 2017;390(10100):1260–344.

Artigos

2016

ReferênciaTipo de Documento
Chen C-Y, Shingai M, Borrego P, Taveira N, Strebel K. Antagonism of BST-2/tetherin is a conserved function of primary HIV-2 Env glycoproteins. Retrovirology. 2016;13(1).

Outras Publicações Indexadas

Pires D, Zagalo A, Santos C, Cota de Medeiros F, Duarte A, Lito L, et al. Evolving epidemiology of carbapenemase-producing Enterobacteriaceae in Portugal: 2012 retrospective cohort at a tertiary hospital in Lisbon. Journal of Hospital Infection. 2016;92(1):82–5.

Artigos

Araujo F, Goncalves J, Eurico Fonseca J. Cost savings with biosimilars in Rheumatology: a systematic literature Search Of Budget Impact Analysis. Annals of the Rheumatic Diseases. 2016 Jun;75(2):879–80.

Outras Publicações Indexadas

Sardari S, Portugal I, ALKafri A, Moradi D, Ghavami G. Fragment-based de novo design of antimycobacterial agents and in vitro potency evaluation. Combinatorial Chemistry and High Throughput Screening. 2016;19(3):238–45.

Artigos

Perdigão J, Maltez F, Machado D, Silva H, Pereira C, Silva C, et al. Beyond extensively drug-resistant tuberculosis in Lisbon, Portugal: a case of linezolid resistance acquisition presenting as an iliopsoas abscess. International Journal of Antimicrobial Agents. 2016;48(5):569–70.

Outras Publicações Indexadas

Figueiredo NL, Canário J, O’Driscoll NJ, Duarte A, Carvalho C. Aerobic Mercury-resistant bacteria alter Mercury speciation and retention in the Tagus Estuary (Portugal). Ecotoxicology and Environmental Safety. 2016;124:60–7.

Artigos

Martin F, Palladino C, Mateus R, Clemente S, Gomes P, Taveira N. Evaluation of an In-house Molecular HIV-1 Test to Assess Mother-to-Child HIV-1 Transmission in Angola (the APEHC Cohort). JAIDS-Journal of Acquired Immune Deficiency Syndromes. 2016 Jan;71(1):73.

Outras Publicações Indexadas

Falcon-Neyra L, Palladino C, Gomez MLN, Soler-Palacin P, Gonzalez-Tome MI, De Ory SJ, et al. Off-label use of rilpivirine in combination with emtricitabine and tenofovir in HIV-1-infected pediatric patients A multicenter study. Medicine (United States). 2016;95(24).

Artigos

Giria M, Santos L, Louro J, de Andrade HR. Reverse genetics vaccine seeds for influenza: Proof of concept in the source of PB1 as a determinant factor in virus growth and antigen yield. Virology. 2016;496:21–7.

Artigos

Fernandes S, Labarde A, Baptista C, Jakutytè L, Tavares P, São-José C. A non-invasive method for studying viral DNA delivery to bacteria reveals key requirements for phage SPP1 DNA entry in Bacillus subtilis cells. Virology. 2016;495:79–91.

Artigos

Bártolo I, Calado R, Borrego P, Leitner T, Taveira N. Rare HIV-1 subtype J genomes and a new H/U/CRF02-AG recombinant genome suggests an ancient origin of HIV-1 in Angola. AIDS Research and Human Retroviruses. 2016;32(8):822–8.

Artigos

Godinho-Santos A, Hance AJ, Goncalves J, Mammano F. CIB1 and CIB2 are HIV-1 helper factors involved in viral entry. Scientific Reports. 2016;6.

Artigos

Azevedo-Pereira JM, Santos-Costa Q. HIV interaction with human host: HIV-2 As a model of a less virulent infection. AIDS Reviews. 2016;18(1):44–53.

Artigos

Fernandes S, Sao-Jose C. More than a hole: the holin lethal function may be required to fully sensitize bacteria to the lytic action of canonical endolysins. Molecular Microbiology. 2016;102(1):92–106.

Artigos

Hurt AC, Besselaar TG, Daniels RS, Ermetal B, Fry A, Gubareva L, et al. Global update on the susceptibility of human influenza viruses to neuraminidase inhibitors, 2014–2015. Antiviral Research. 2016;132:178–85.

Artigos

Bettencourt P, Pires D, Anes E. Immunomodulating microRNAs of mycobacterial infections. Tuberculosis. 2016 Mar;97:1–7.

Artigos

Doering M, Borrego P, Büch J, Martins A, Friedrich G, Camacho RJ, et al. A genotypic method for determining HIV-2 coreceptor usage enables epidemiological studies and clinical decision support. Retrovirology. 2016;13(1).

Artigos

Justino GC, Pinheiro PF, Roseiro APS, Knittel ASO, Gonçalves J, Justino MC, et al. Camphor-based CCR5 blocker lead compounds-a computational and experimental approach. RSC Advances. 2016;6(61):56249–59.

Artigos

Doerner T, Strand V, Cornes P, Goncalves J, Gulacsi L, Kay J, et al. The changing landscape of biosimilars in rheumatology. Annals of the Rheumatic Diseases. 2016 Jun;75(6):974–82.

Artigos

Cunha-Santos C, Figueira TN, Borrego P, Oliveira SS, Rocha C, Couto A, et al. Development of synthetic light-chain antibodies as novel and potent HIV fusion inhibitors. AIDS. 2016;30(11):1691–701.

Artigos

Kushkevych I, Kollar P, Ferreira AL, Palma D, Duarte A, Lopes MM, et al. Antimicrobial effect of salicylamide derivatives against intestinal sulfate-reducing bacteria. Journal of Applied Biomedicine. 2016;14(2):125–30.

Artigos

Goncalves J, Araujo F, Cutolo M, Fonseca JE. Biosimilar monoclonal antibodies: preclinical and clinical development aspects. Clinical and Experimental Rheumatology. 2016;34(4):698–705.

Artigos

Chen C-Y, Shingai M, Welbourn S, Martin MA, Borrego P, Taveira N, et al. Antagonism of BST-2/tetherin is a conserved function of the Env glycoprotein of primary HIV-2 isolates. Journal of Virology. 2016;90(24):11062–74.

Artigos

Machado D, Pires D, Perdigão J, Couto I, Portugal I, Martins M, et al. Ion channel blockers as antimicrobial agents, efflux inhibitors, and enhancers of macrophage killing activity against drug resistant mycobacterium tuberculosis. PLoS ONE. 2016;11(2).

Artigos

Piedade D, Azevedo-Pereira JM. MicroRNAs, HIV and HCV: a complex relation towards pathology. Reviews In Medical Virology. 2016;26(3):197–215.

Artigos

2018
º lugar da 2.ª edição do Prémio Janssen Inovação

2016
Lugar do Prémio Janssen Inovação 2016
Bolsa do Programa Gilead GÉNESE 2016
“Top Communication Award”
Best Oral Presentation. 8th Biennial Congress of the Spanish Society for Gene and Cell Therapy.
Best Oral Presentation. 8th iMed.ULisboa Postgraduate Students Meeting. 2016.

Contactos

Edifício F e CPM
Tel.: +351 217 946 400
Extensão interna: 14512
E-mail: joao.goncalves@ff.ulisboa.pt

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