After completion of the course, students will be expected to:
Chemogenomics in target and drug discovery; chemical libraries, chemical space and biological space;
Bioorthogonal chemistry in the context of probe design and synthesis; molecular probes for real-time imaging in live cells;
Identification of catalytic proteins in proteomes and activity-based probes (activity-based protein profiling); Identification of non-catalytic proteins in proteomes and (photo)affinity-based probes (affinity-based protein profiling); proteomics and target identification.
Detection methods and interaction of radiation and particles with matter; the nuclear techniques (SPECT/PET) for molecular imaging; design and development of radiopharmaceuticals; (radio)chemistry of metal and non-metal elements relevant to targeting, bioconjugation and pharmacokinetics modulation.