At the end of the course students should demonstrate integrated knowledge of the scientific principles that support the multidisciplinary field of Pharmaceutical Scienses in its diferente componentes, particularly pharmacology (pharmacodinamics), pharmacokinetics, medicinal/therapeutic chemistry and pharmaceutics. The focus is not only to develop specific aspects of each subject but also to establish clearly their common scientific base.
In addition to the basic and general concepts needed in the first apprach to the pharmaceutical sciences (physics, mathematics, physical chemistry, organic chemistry, physiology, biochemistry, cellular and molecular biology and genetics)
Physicochemical determinants of drug activity: administration and route of drugs in the body; hydro and liposolubility; ionization; kinetics of pharmaceutical processes; membranes and tissues. Action of drugs: drug-molecular target binding: transport through biological membranes; endogenous and exogenous ligands; receptors and signal transmission process; mechanisms of action; dose-response or concentration-response relationships; pharmacological classification; drug discovery and optimization; variability and Pharmacogenetics. Pharmacokinetics and ADME: absorption, solubility and dissolution; distribution; metabolism; excretion; concentration / time curve. Administration of drugs: drug delivery systems; innovation and research in the pharmaceutical industry.