Master in Pharmaceutical Engineering

Pharmaceutical Biotechnology and Bioengineering

ECTS

6

Learning outcomes

Module I - Genetic Engineering, Functional Genomics and Bioinformatics- Learning the fundaments and the experimental and computational approaches involved in recombinant DNA technology and in other molecular methods and their applications, in particular those characteristic of the post-genomic age, using an inter- disciplinary approach and focusing the Pharmaceutical Industry.

Module II - Biotechnology and Bioengineering. Learning the fundamentals of pharmaceuticals biotechnology production: importance of these compounds, from the sources to the market. The students must acquire an integrated formation through the learning of the fundamental of cellular cultures, bioreactors, and biopharmaceuticals from Bioengineering towards Biomedicine.

Syllabus

Module I - Genetic Engineering, Functional Genomics and Bioinformatics
Recombinant DNA technology. PCR. Southern hybridazation. Genotyping. Gene expression analysis: fusions with a reporter gene, Northern hybridization, RT- PCR.Gene deletion or mutation.Directed mutagenesis. Genome sequence and annotation.Databases and Bioinformatics tools.Functional Genomics. Transcriptomics and expression proteomics. Aplications focusing the Pharmaceutical Industry.
Module II - Bioengineering, Biopharmaceuticals & Biomedicine
Biocatalysts: enzymes and cells.Stoichiometry and kinetics of cellular growth. Protein engineering. Bioreactors: geometry and operation mode. Project and modulation of fermentors. Biopharmaceuticals: production, separation, purification and validation. Monoclonal Antibodies.Vaccines. Cellular and gene therapy.Biomaterials. Viral vectors.Applications.

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