Master in Laboratory Medicine

Clinical Virology

ECTS

6

Learning outcomes

After completion of this curricular unit, the student will be able to:
OB1­ Identify the processes of viral replication
OB2­ Define the mechanisms involved in virus­cell interaction
OB3­ Define the pathogenic mechanisms involved in virus­host interactions
OB4­ Distinguish the mechanisms underlying acute vs. chronic infections as well as localized vs. systemic infections
OB5­ Identify the viral and host factors responsible for viral persistence
OB6­ Define the consequences of viral replication within the host – i.e. the pathogenic mechanisms and characteristics of the main viral diseases.
OB7­ Describe and interpret the clinical signs associated with main viral infections
OB8­ Describe and interpret the methods used for viral diagnosis.

Syllabus

Lectures
CT1­ Objectives and evaluation. General characteristics of viruses, structure and classification
CT2­ Replication cycle; Viral tropism; Viral genetics
CT3 ­Pathogenesis of viral infections. Acute and chronic infections
CT4­ Viral families Herpesviridae and Polyomaviridae
CT5­ Viral infections of respiratory tract and gastroenteritis, rubella virus and enteroviruses
CT6­ HIV and other retroviruses; prions­associated diseases
CT7­ Viral oncogenesis: General mechanisms and examples (HTLV, HPV, EBV, HHV­8)
CT8­ Emerging viral infections: Factors and mechanisms; Examples: Rabies virus, haemorrhagic fever viruses, West­Nile virus, Dengue virus, Poxviruses

Practical classes
Interpretation of clinical cases focusing the diagnosis of CP1­CMV and rubella virus
CP2­HBV CP3­HIV

Laboratory classes
CL1­Laboratory safety and biohazard safety levels. Main techniques used in the diagnosis of viral infections
CL2­Laboratory diagnosis of HSV and CMV infections
CL3­Laboratory diagnosis of HIV infection

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