After the course, the student is expected to be able to:
-Draw the mechanisms and identify the products of drug degradation pathways. Determine the reaction kinetic parameters, calculate the half-lives of drug degradation and draw the pH-rate profiles. Identify the pH ranges of greater or lesser stability of the drugs.
- For the classes of drugs taught in the course, students should be able to correlate the potency of the drugs and the type of interactions established with the molecular target. Describe qualitatively the structure-activity relationships and discuss their significance. Establish the synthetic routes for some examples of drugs presented in the lectures.
- Relatively to Pharmaceutical Inorganic Chemistry students should understand the chemical mechanisms associated with therapeutic activity, toxicity and essentiality of some key elements of periodic table.
The UC starts with the introduction of some concepts needed for the study of chemical stability of drugs and cover the study of important classes of drugs (steroids, peptidomimetics, antiviral, antibacterial and antimalarial drugs, opioid analgesics, drugs affecting the adrenergic system; anti-ulcer agents; antibody drug conjugates). Emphasis will be placed on physical and chemical properties of drugs, structure-activity relationships and the molecular basis for drug-receptor interactions. Finally the course will have a topic in inorganic pharmaceutical chemistry that will cover: i) therapeutic agents for osteoporosis; ii) the role of metals on complexes formation; iii) inorganic compounds used in imaging.
In the lab classes students synthesize and characterize compounds with pharmacological activity. They also perform a complete monographic study of an inscribed inorganic compound in the Portuguese Pharmacopeia.
Exercises related with lecture topics are solved in tutorials.