Integrated Master in Pharmaceutical Sciences

Organic Chemistry II

ECTS

6

Learning outcomes

Organic Chemistry II course completes the acquisition of competences on organic chemistry that have impact on the understanding of drug action and drug analysis. The main goals of this course is to train the students with the skills and knowledge on the structure, synthesis and reactivity of organic compounds, that are required to address the challenges involved in drug synthesis, drug design, drug action and drug analysis.

Specifically, this course is designed to give emphasis to the study of structure-reactivity, and it is intended that the students learn the structure, the synthesis and the reactivity of functional groups not studied in previous courses.

Syllabus

  • Aldehydes and ketones: nucleophilic addition to the carbonyl group: . Structure. Nomenclature. Physical properties. Spectroscopy. Synthesis. Reactivity.
  • Carboxylic acids and Derivatives. Structure. Nomenclature. Physical properties. Spectroscopy. Synthesis. Nucleophilic substitution reaction: addition-elimination mechanism. Relative reactivity.
  • Formation and reactivity of enols and enolates. Aldol condensation. α,β-Unsaturated carbonyl compounds.
  • Ester enolates: formation and reactivity. Claisen condensation. β-dicarbonyl compounds.
  • Aromatic compounds. Aromaticity. Nomenclature. Physical properties. Spectroscopy. Electrophilic and nucleophilic aromatic substitution reactions.
  • Amines and derivatives. Nomenclature. Physical properties. Spectroscopy. Synthesis. Reactivity.
  • Heterocycles. Nomenclature. Structures and properties. Synthesis and reactivity.

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