Clinical Pharmacokinetics encompasses the application of Pharmacokinetic (PK) concepts to clinical settings, namely what is currently called as Therapeutic Drug Monitoring (TDM). TDM aims to promote the optimization of drug treatment by maintaining drug concentrations within a therapeutic range. It is especially important for those drugs which are characterized as Narrow Therapeutic Index.
The course includes a brief review of basic PK concepts (compartmental/non compartmental analysis); physiological determinants of PK parameters (ADME); application of PK principles to dosing regimens; variability and individual optimisation of posology and basics of population PK. Finally the course focus on the study of individual drugs: theophylline; aminoglicosides and vancomycin; digoxin; anticonvulsants (phenobarbital, phenytoin, carbamazepine, valproate, lamotrigin), immunosuppressive drugs (cyclosporin, sirolimus, tacrolimus, mycophenolate) and antiviral drugs (zidovudine, stavudine, lamivudine, zalcitabine).