Pharmacy practice is an area of study that focuses on the role of pharmacists in promoting the safe and effective use of medicines and medical devices. Even though medicines are the most regulated health technology and one of the most effective health interventions in routine clinical practice, a minority of people uses them appropriately. Therefore, it is essential first to understand the determinants of inappropriate use of medicines and people’s experiences using medication. As a result, interventions that focus on optimising the responsible use of medicines are likely to be developed as a core function of pharmacists’ role. Therefore, pharmacy practice research studies come to play and can adopt varied formats, resorting to methodologies used initially in epidemiology, including observational and experimental studies, whilst combining these with methods primarily used in the social sciences. These methodologies enable taking a more person-centred approach to understanding the experience of people living with illness and relying on medication and medical devices for maintaining their health and well-being.