Ciências Farmacológicas

Principais atividades

Ensino de 1.º, 2.º e 3.º ciclos.
Investigação científica e desenvolvimento tecnológico.
Serviços de extensão universitária:
            serviços ao exterior
            atividades complementares no domínio da formação contínua e da promoção da inovação.


O DCF está ativamente envolvido na lecionação de vários cursos da FFUL e também de alguns cursos em associação com Escolas da ULisboa ou outras instituições de ensino superior.

Especialidades de Biofarmácia e Farmacocinética, Farmacognosia e Etnofarmacologia, Farmacologia e Farmacoterapia.

Ciências da Saúde (ciclo de estudos em associação)

Mestrado Integrado
Mestrado Integrado em Engenharia Biomédica e Biofísica da Faculdade de Ciências da ULisboa
Mestrado Integrado em Ciências Farmacêuticas da Faculdade de Ciências e Tecnologia da Universidade do Algarve

Mestrado em Química de Produtos Naturais da Faculdade de Ciências Naturais e Matemática da Universidade Pedagógica, Maputo - Moçambique

Cursos Não Conferentes de Grau
Curso Pós-graduado de Especialização em Medicamentos à base de Plantas
Curso Pós-graduado de Actualização em Medicamentos Homeopáticos
Curso Pós-graduado de Actualização em Plantas Medicinais e Fitoterapia


Instituto de Investigação do Medicamento (iMed.ULisboa)
            Grupo de investigação:
            Ciências Farmacológicas e Regulamentar



  • Aartsma-Rus A, Straub V, Hemmings R, Haas M, Schlosser-Weber G, Stoyanova-Beninska V, et al. Development of Exon Skipping Therapies for Duchenne Muscular Dystrophy: A Critical Review and a Perspective on the Outstanding Issues. Nucleic Acid Therapeutics. 2017;27(5):251–9.
  • Alexandre-Pires G, Martins C, Galvão AM, Miranda M, Silva O, Ligeiro D, et al. Understanding the inguinal sinus in sheep (Ovis aries)—Morphology, secretion, and expression of progesterone, estrogens, and prolactin receptors. International Journal of Molecular Sciences. 2017;18(7).
  • Buesen R, Chorley BN, Lima B da S, Daston G, Deferme L, Ebbels T, et al. Applying `omics technologies in chemicals risk assessment: Report of an ECETOC workshop. Regulatory Toxicology and Pharmacology. 2017;91(1):S3–13.
  • Carvalho M, Sepodes B, Martins AP. Regulatory and Scientific Advancements in Gene Therapy: State-of-the-Art of Clinical Applications and of the Supporting European Regulatory Framework. Frontiers in Medicine. 2017;4.
  • Cavaco MC, Pereira C, Kreutzer B, Gouveia LF, Silva-Lima B, Brito AM, et al. Evading P-glycoprotein mediated-efflux chemoresistance using Solid Lipid Nanoparticles. European Journal of Pharmaceutics and Biopharmaceutics. 2017;110:76–84.
  • De Mello-Sampayo C, Agripino AA, Stilwell D, Vidal B, Fernando AL, Silva-Lima B, et al. Chronic Hyperglycemia Modulates Rat Osteoporotic Cortical Bone Microarchitecture into Less Fragile Structures. International Journal of Endocrinology. 2017;2017.
  • de Mello-Sampayo C, Canhao H, Rodrigues A, Branco J, Marques MC. Usefulness of FRAX to predict the risk of fractures in a diabetic Portuguese population. Diabetologia. 2017;60(1):S556.
  • De Mello-Sampayo C, Paterna A, Polizzi A, Duarte D, Batista I, Pinto R, et al. Evaluation of marine microalga Diacronema vlkianum biomass fatty acid assimilation in Wistar rats. Molecules. 2017;22(7).
  • Direito R, Lima A, Rocha J, Ferreira RB, Mota J, Rebelo P, et al. Dyospiros kaki phenolics inhibit colitis and colon cancer cell proliferation, but not gelatinase activities. Journal of Nutritional Biochemistry. 2017;46:100–8.
  • dos Santos Madeira MS, Alves Rolo ES, Rico Pires VM, Pereira Mateus Alfaia CMR, Mauricio Coelho DF, Antunes Bras Lopes PA, et al. Arginine supplementation modulates pig plasma lipids, but not hepatic fatty acids, depending on dietary protein level with or without leucine. BMC Veterinary Research. 2017;13.
  • Duarte H, Cruz JP, Aniceto N, Ribeiro AC, Fernandes A, Paixão P, et al. Population Approach to Efavirenz Therapy. Journal of Pharmaceutical Sciences. 2017;106(10):3161–6.
  • Farkas AM, Mariz S, Stoyanova-Beninska V, Celis P, Vamvakas S, Larsson K, et al. Advanced Therapy Medicinal Products for Rare Diseases: State of Play of Incentives Supporting Development in Europe. Frontiers In Medicine. 2017;4.
  • Goldring C, Antoine DJ, Bonner F, Crozier J, Denning C, Fontana RJ, et al. Stem cell–derived models to improve mechanistic understanding and prediction of human drug-induced liver injury. Hepatology. 2017;65(2):710–21.
  • Hens B, Tsume Y, Bermejo M, Paixao P, Koenigsknecht MJ, Baker JR, et al. Low Buffer Capacity and Alternating Motility along the Human Gastrointestinal Tract: Implications for in Vivo Dissolution and Absorption of Ionizable Drugs. Molecular Pharmaceutics. 2017;14(12):4281–94.
  • Lopes PA, Bandarra NM, Martins SV, Martinho J, Alfaia CM, Madeira MS, et al. Markers of neuroprotection of combined EPA and DHA provided by fish oil are higher than those of EPA (Nannochloropsis) and DHA (Schizochytrium) from microalgae oils in Wistar rats. Nutrition and Metabolism. 2017;14(1).
  • Machado M, Sanches-Vaz M, Cruz JP, Mendes AM, Prudêncio M. Inhibition of Plasmodium hepatic infection by antiretroviral compounds. Frontiers in Cellular and Infection Microbiology. 2017;7(JUL)
  • Madeira MSMS, Rolo ESA, Pires VMR, Alfaia CMRPM, Coelho DFM, Lopes PAAB, et al. Arginine supplementation modulates pig plasma lipids, but not hepatic fatty acids, depending on dietary protein level with or without leucine. BMC Veterinary Research. 2017;13(1)
  • Malmir M, Serrano R, Silva O. Anthraquinones as potential antimicrobial agents-A review. In: A. Méndez-Vilas, editor. Antimicrobial research: Novel bioknowledge and educational programs. Badajoz: Formatex Research Center; 2017. p. 55-61.
  • Marques MC, de Mello-Sampayo C, Canhao H. Estimating the risk of osteoporosis related fractures in a post-menopause type 2 diabetic Portuguese population. Diabetologia. 2017;60(1):S556.
  • Mateus V, Rocha J, Alves P, Mota-Filipe H, Sepodes B, Pinto R. Thiadiazolidinone-8 ameliorates inflammation associated with experimental colitis in mice. Pharmacology. 2017;101(1–2):35–42
  • Mateus V, Rocha J, Alves P, Mota-Filipe H, Sepodes B, Pinto RMA. Anti-Inflammatory Effect of Erythropoietin in the TNBS-induced Colitis. Basic and Clinical Pharmacology and Toxicology. 2017;120(2):138–45
  • Neves A, Marto J, Duarte A, Goncalves LM, Pinto P, Figueiredo AC, et al. Characterization of Portuguese Thymbra capitata, Thymus caespititius and Myrtus communis essential oils in topical formulations. Flavour and Fragrance Journal. 2017;32(5):392–402
  • Paixão P, Gouveia LF, Silva N, Morais JAG. Evaluation of dissolution profile similarity – Comparison between the f2, the multivariate statistical distance and the f2 bootstrapping methods. European Journal of Pharmaceutics and Biopharmaceutics. 2017;112:67–74
  • Pereira AMPT, Silva LJG, Laranjeiro CSM, Meisel LM, Lino CM, Pena A. Human pharmaceuticals in Portuguese rivers: The impact of water scarcity in the environmental risk. Science of the Total Environment. 2017;609:1182–91
  • Pereira AMPT, Silva LJG, Lino CM, Meisel LM, Pena A. A critical evaluation of different parameters for estimating pharmaceutical exposure seeking an improved environmental risk assessment. Science of the Total Environment. 2017;603–604:226–36
  • Polsinelli B, Tsigkos S, Naumann-Winter F, Mariz S, Sepodes B. Evolving prevalence of haematological malignancies in orphan designation procedures in the European Union. Orphanet Journal of Rare Diseases. 2017;12(1)
  • Rocha C, Silva H, Frazao I, Castelao V, Ferreira H, Monteiro Rodrigues L. Exploring the impact of massage on peripheral microcirculation with the wavelet transform. Journal of Vascular Research. 2017;54(1):34.
  • Rodrigues LM, Palma L, Santos O, Almeida MA, Bujan J, Tavares L. Excessive Weight Favours Skin Physiology - Up to a Point: Another Expression of the Obesity Paradox. Skin Pharmacology and Physiology. 2017;30(2):94–101
  • Rosado C, Antunes F, Barbosa R, Fernando R, Estudante M, Silva HN, et al. About the in vivo quantitation of skin anisotropy. Skin Research and Technology. 2017;23(3):429–36
  • Silva H, Ferreira H, Gadeau AP, Rodrigues LM. Exploring the murine microvascular response variability to hyperoxia with the wavelet transform. Acta Physiologica. 2017;221(713, SI):224.
  • Silva H, Frazao I, Miranda R, Monteiro Rodrigues L. About the in vivo effects of hyperoxia in human. Journal of Vascular Research. 2017;54(1):35.
  • Silva H, Frazao I, Miranda R, Monteiro Rodrigues L. Comparing the in vivo spectral components of Laser Doppler Flowmetry and Photoplethysmography by the wavelet transform to assess microcirculation. Journal of Vascular Research. 2017;54(1):36.
  • Silva H, Vieira H, Bento M, Frazao I, Rodrigues LM. About the human vascular response to hyperoxia. Acta Physiologica. 2017;221(713, SI):78.
  • Silva LJG, Pereira AMPT, Rodrigues H, Meisel LM, Lino CM, Pena A. SSRIs antidepressants in marine mussels from Atlantic coastal areas and human risk assessment. Science of the Total Environment. 2017;603–604:118–25
  • Silva O, Serrano R. Micromorphological studies for application in the quality control of herbal medicines-some data of plants used in Mozambique. In: Méndez-Vilas A, editor. Microscopy and imaging science: practical approaches to applied research and education. Badajoz: Formatex Research Center; 2017. p. 231–6.


  • Bandarra NM, Lopes PA, Martins SV, Ferreira J, Alfaia CM, Rolo EA, et al. Docosahexaenoic acid at the sn-2 position of structured triacylglycerols improved n-3 polyunsaturated fatty acid assimilation in tissues of hamsters. Nutrition Research. 2016;36(5):452–63.
  • Crommelin DJA, Broich K, Holloway C, Meesen B, Lizrova Preiningerova J, Prugnaud J-L, et al. The regulator’s perspective: How should new therapies and follow-on products for MS be clinically evaluated in the future? Multiple Sclerosis. 2016;22:47–59.
  • Encarnação S, de Mello-Sampayo C, Graça NAG, Catarino L, da Silva IBM, Lima BS, et al. Total phenolic content, antioxidant activity and pre-clinical safety evaluation of an Anacardium occidentale stem bark Portuguese hypoglycemic traditional herbal preparation. Industrial Crops and Products. 2016;82:171–8.
  • Estudante M, Soveral G, Morais JG, Benet LZ. Insights into solute carriers: physiological functions and implications in disease and pharmacokinetics. MedChemComm. 2016;7(8):1462–78.
  • Figueira M-E, Oliveira M, Direito R, Rocha J, Alves P, Serra A-T, et al. Protective effects of a blueberry extract in acute inflammation and collagen-induced arthritis in the rat. Biomedicine and Pharmacotherapy. 2016;83:1191–202.
  • Gaffney VJ, Mota-Filipe H, Pinto RA, Thiemermann C, Loureiro M, Cardoso VV, et al. Chemical and biochemical characterization and in vivo safety evaluation of pharmaceuticals in drinking water. Environmental Toxicology and Chemistry. 2016;35(11):2674–82.
  • Goncalves J, Graca L, Moreira JN, Figueiredo I V, Scappaticci F, Eurico Fonseca J, et al. Development of e-learning platform about biologic drugs with focus on monoclonal antibodies. International Journal of Clinical Pharmacy. 2016;38(2):519–20.
  • Madeira MS, Pires VMR, Alfaia CM, Lopes PA, Martins SV, Pinto RMA, et al. Restriction of dietary protein does not promote hepatic lipogenesis in lean or fatty pigs. British Journal of Nutrition. 2016;115(8):1339–51.
  • Mariz S, Reese JH, Westermark K, Greene L, Goto T, Hoshino T, et al. Worldwide collaboration for orphan drug designation. Nature Reviews Drug Discovery. 2016;15(6):440.
  • Morel T, Lhoir A, Picavet E, Mariz S, Sepodes B, Llinares J, et al. The orphan drug pipeline in Europe. Nature Reviews Drug Discovery. 2016;15(6):376.
  • Paixão P, Gouveia L, Morais J, Silva N. Correlation between cell- and tissue-based in vitro models for drug permeability screening with in vivo situation. In: Concepts and Models for Drug Permeability Studies: Cell and Tissue based In Vitro Culture Models. Amsterdam: Elsevier; 2016. p. 357–71.
  • Pereira AMPT, Silva LJG, Lino CM, Meisel LM, Pena A. Assessing environmental risk of pharmaceuticals in Portugal: An approach for the selection of the Portuguese monitoring stations in line with Directive 2013/39/EU. Chemosphere. 2016;144:2507–15.
  • Ramalhete N, Machado A, Serrano R, Gomes ET, Mota-Filipe H, Silva O. Comparative study on the in vivo antidepressant activities of the Portuguese Hypericum foliosum, Hypericum androsaemum and Hypericum perforatum medicinal plants. Industrial Crops and Products. 2016;82:29–36.
  • Róis AS, Sádio F, Paulo OS, Teixeira G, Paes AP, Espírito-Santo D, et al. Phylogeography and modes of reproduction in diploid and tetraploid halophytes of Limonium species (Plumbaginaceae): Evidence for a pattern of geographical parthenogenesis. Annals of Botany. 2016;117(1):37–50.
  • Silva LJG, Martins MC, Pereira AMPT, Meisel LM, Gonzalez-Rey M, Bebianno MJ, et al. Uptake, accumulation and metabolization of the antidepressant fluoxetine by Mytilus galloprovincialis. Environmental Pollution. 2016;213:432–7.
  • Sousa M, Machado V, Costa R, Figueira ME, Sepodes B, Barata P, et al. Red Raspberry Phenols Inhibit Angiogenesis: A Morphological and Subcellular Analysis Upon Human Endothelial Cells. Journal of Cellular Biochemistry. 2016;117(7):1604–12.
  • Sponchiado G, Adam ML, Silva CD, Silva Soley B, De Mello-Sampayo C, Cabrini DA, et al. Quantitative genotoxicity assays for analysis of medicinal plants: A systematic review. Journal of Ethnopharmacology. 2016;178:289–96.
  • Straub V, Balabanov P, Bushby K, Ensini M, Goemans N, De Luca A, et al. Stakeholder cooperation to overcome challenges in orphan medicine development: The example of Duchenne muscular dystrophy. The Lancet Neurology. 2016;15(8):882–90.
  • Teixeira G, Martins ES, Catarino L. Antidepressant plant species from the Portuguese-speaking African countries (PALOP). In: Herbal Medicine in Depression: Traditional Medicine to Innovative Drug Delivery. Springer; 2016.p. 433-81.
  • van der Laan JW, Kasper P, Lima BS, Jones D, Pasanen M. Overview of pharmacology-induced mechanisms of carcinogenesis. Toxicology Letters. 2016;258(S):S44.
  • van der Laan JW, Kasper P, Silva Lima B, Jones DR, Pasanen M. Critical analysis of carcinogenicity study outcomes. Relationship with pharmacological properties. Critical Reviews in Toxicology. 2016;46(7):587–614.
  • Wagemaker TAL, Maia Campos PMBG, Fernandes AS, Rijo P, Nicolai M, Roberto A, et al. Unsaponifiable matter from oil of green coffee beans: cosmetic properties and safety evaluation. Drug Development and Industrial Pharmacy. 2016;42(10):1695–9.


Localização: Edifício H - C.3.7
Tel.: +351 217 946 400
Extensão interna: 14339